The role of innate immunity in asthma: Leads and lessons from mouse models

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 6, 2007, Pages 579-590

  Schroder N W J ^a   Maurer, M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Asthma; Dendritic cells; Mast cells; Mouse models; Toll like receptors

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTATION; ASTHMA; DENDRITIC CELL; HUMAN; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENSITIZATION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; ASTHMA; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, NATURAL; MAST CELLS; MICE; RESPIRATORY TRACT INFECTIONS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 34248545340     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01386.x     Document Type: Review

References (115)

1. Beasley R, Crane J, Lai CK, Pearce N. Prevalence and etiology of asthma. J Allergy Clin Immunol 2000 105 : 466 472.
2. Wild JS, Sur S. CpG oligonucleotide modulation of allergic inflammation. Allergy 2001 S6 : 365 376.
3. Umetsu DT, Mclntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002 3 : 715 720.
4. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest 2003 111 : 291 297.
5. Conn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med 1997 186 : 1737 1747.
6. Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994 12 : 635 673.
7. Hamelmann E, Gelfand EW. IL-5-induced airway eosinophilia - the key to asthma?. Immunol Rev 2001 179 : 182 191.
8. Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 2002 195 : 1433 1444.
9. Justice JP, Borchers MT, Crosby JR, Hines EM, Shen HH, Ochkur SI et al. Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol 2003 284 : 169 178.
10. Costello PS, Turner M, Walters AE, Cunningham CN, Bauer PH, Downward J et al. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 1996 13 : 2595 2605.
11. Cookson W. The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol 2004 4 : 978 988.
12. von Mutius E, Pearce N, Beasley R, Cheng S, von Ehrenstein O, Bjorksten B et al. International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema. Thorax 2000 55 : 449 553.
13. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997 275 : 77 79.
14. Mclntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001 2 : 1109 1116.
15. Sheikh A, Smeeth L, Hubbard R. There is no evidence of an inverse relationship between TH2-mediated atopy and THl-mediated autoimmune disorders: Lack of support for the hygiene hypothesis. J Allergy Clin Immunol 2003 111 : 131 135.
16. Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engf J Med 2002 347 : 869 877.
17. Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000 355 : 1680 1683.
18. Eldridge MW, Peden DB. Allergen provocation augments endotoxin-induced nasal inflammation in subjects with atopic asthma. J Allergy Clin Immunol 2000 105 : 475 481.
19. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001 163 : 322 328.
20. Dahl ME, Dabbagh K, Liggitt D, Kim S, Lewis DB. Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat Immunol 2004 5 : 337 343.
21. Umetsu DT. Flu strikes the hygiene hypothesis. Nat Med 2004 10 : 232 234.
22. Schwarze J, Hamelmann E, Bradley KL, Takeda K, Gelfand EW. Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 1997 100 : 226 233.
23. Marsland BJ, Scanga CB, Kopf M, Le Gros G. Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells. Clin Exp Allergy 2004 34 : 1299 1306.
24. Beyer M, Bartz H, Horner K, Doths S, Koerner-Rettberg C, Schwarze J. Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection. J Allergy Clin Immunol 2004 13 : 127 133.
25. Yssel H, Johnson KE, Schneider PV, Wideman J, Terr A, Kastelein R et al. T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones. J Immunol 1992 148 : 738 745.
26. Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM et al. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005 202 : 1549 1561.
27. Sur S, Lam J, Bouchard P, Sigounas A, Holbert D, Metzger VJ. Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. J Immunol 1996 157 : 4173 4180.
28. Banerjee B, Kelly KJ, Fink JN, Henderson Jr. JD, Bansal NK, Kurup VP. Modulation of airway inflammation by immunostimulatory CpG oligodeoxynucleotides in a murine model of allergic aspergillosis. Infect Immun 2004 72 : 6087 6094.
29. Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA, Pauwels RA et al. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 1994 24 : 73 80.
30. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 1990 250 : 1720 1723.
31. Shakib F, Schulz O, Sewell H. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity. Immunol Today 1998 19 : 313 316.
32. Selo I, Negroni L, Creminon C, Yvon M, Peltre G, Wal JM. Allergy to bovine beta-lactoglobulin: specificity of human IgE using cyanogen bromide-derived peptides. Int Arch Allergy Immunol 1998 117 : 20 28.
33. Shakib F, Hooi DS, Smith SJ, Furmonaviciene R, Sewell HF. Identification of peptide motifs recognized by a human IgG autoanti-IgE antibody using a phage display library. Clin Exp Allergy 2000 30 : 1041 1046.
34. Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002 196 : 1645 1651.
35. Watanabe J, Miyazaki Y, Zimmerman GA, Albertine KH, Mclntyre TM. Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity. J Biol Chem 2003 278 : 42361 42368.
36. Kurup VP, Grunig G. Animal models of allergic bronchopulmonary aspergillosis. Mycopathologia 2002 153 : 165 177.
37. Stevens TL, Bossie A, Sanders VM, Fernandez-Botran R, Coffman RL, Mosmann TR et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 1988 334 : 255 258.
38. Martin TR, Gerard NP, Galli SJ, Drazen JM. Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol 1988 64 : 2318 2323.
39. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997 156 : 766 775.
40. Robinson MK, Babcock LS, Horn PA, Kawabata TT. Specific antibody responses to subtilisin Carlsberg (Alcalase) in mice; development of an intranasal exposure model. Fundam Appl Toxicol 1996 34 : 15 24.
41. Robinson MK, Horn PA, Kawabata TT, Babcock LS, Fletcher ER, Sarlo K. Use of the mouse intranasa! test (MINT) to determine the allergenic potency of detergent enzymes: comparison to the guinea pig intratracheal (GPIT) test. Toxicol Sci 1998 43 : 39 46.
42. Medzhitov R, Janeway Jr. CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997 91 : 295 298.
43. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001 135 45.
44. Beutler B. The Toll-like receptors: analysis by forward genetic methods. Immunogenetics 2005 57 : 385 392.
45. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998 282 : 2085 2088.
46. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999 189 : 1777 1782.
47. Goyert SM, Ferrero E, Rettig WJ, Yenamandra AK, Obata F, Le Beau MM. The CD 14 monocyte differentiation antigen maps to a region encoding growth factors and receptors. Science 1988 239 : 497 500.
48. Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999 274 : 17406 17409.
49. Schroder NW, Morath S, Alexander C, Hamann L, Hartung T, Zahringer U et al. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 2003 278 : 15587 15594.
50. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. JBiol Chem 1999 274 : 33419 33425.
51. Schroder NW, Opitz B, Lamping N, Michelsen KS, Zahringer U, Gobel UB et al. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids. J Immunol 2000 165 : 2683 2693.
52. Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol 2003 4 : 1223 1229.
53. Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997 385 : 540 544.
54. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997 388 : 548 554.
55. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 2003 4 : 1144 1150.
56. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H et al. Role of adaptor TRIP in the MyD88-independent toll-like receptor signaling pathway. Science 2003 301 : 640 643.
57. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003 424 : 743 748.
58. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of 1RF7 with MyD88 and TRAF6. Nat Immunol 2004 5 : 1061 1068.
59. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
60. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004 5 : 987 995.
61. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001 2 : 947 950.
62. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 I036.
63. Shi HZ, Qin XJ. CD4CD25 regulatory T lymphocytes in allergy and asthma. Allergy 2005 60 : 986 995.
64. Dabbagh K, Dahl ME, Stepick-Biek P, Lewis DB. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 2002 168 : 4524 4530.
65. Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA et al. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest 2005 15 : 459 467.
66. Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 2003 171 : 4984 4989.
67. Constant SL, Lee KS, Bottomly K. Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol 2000 30 : 840 847.
68. Redecke V, Hacker H, Datta SK, Fermin A, Pitha PM, Broide DH et al. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004 172 : 2739 2743.
69. Yamamoto K, Kawamura I, Ito J, Mitsuyama M. Modification of allergic inflammation in murine model of rhinitis by different bacterial ligands: involvement of mast cells and dendritic cells. Clin Exp Allergy 2006 36 : 760 769.
70. Asselin-Paturel C, Trinchieri G. Production of type I interferons: plasmacytoid dendritic cells and beyond. J Exp Med 2005 202 : 461 465.
71. Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006 5 : 471 484.
72. Punturieri A, Alviani RS, Polak T, Copper P, Sonstein J, Curtis JL. Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. J Immunol 2004 173 : 1033 1042.
73. Vermaelen K, Pauwels R. Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: methodology and new insights. Cytometry A 2004 61 : 170 177.
74. Holt PG, Schon-Hegrad MA, Oliver J. MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 1988 167 : 262 274.
75. Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (la)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991 173 : 1345 1356.
76. Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 1993 177 : 397 407.
77. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001 2 : 725 731.
78. Ostroukhova M, Seguin-Devaux C, Oriss TB, Dixon-McCarthy B, Yang L, Ameredes BT et al. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 2004 114 : 28 38.
79. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003 9 : 582 588.
80. Hachem P, Lisbonne M, Michel ML, Diem S, Roongapinun S, Lefort J et al. Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice; role of IFN-gamma. Eur J Immunol 2005 35 : 2793 2802.
81. Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels RA. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 2000 I06 : 551 559.
82. Lambrecht BN. Dendritic cells and the regulation of the allergic immune response. Allergy 2005 60 : 271 282.
83. Hammad H, Lambrecht BN, Pochard P, Gosset P, Marquillies P, Tonnel AB et al. Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7. J Immunol 2002 169 : 1524 1534.
84. Moller GM, Overbeek SE, Van Helden-Meeuwsen CG, Van Haarst JM, Prens EP, Mulder PG et al. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy 1996 26 : 517 524.
85. Jahnsen FL, Moloney ED, Hogan T, Upham JW, Burke CM, Holt PG. Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 2001 56 : 823 826.
86. van Rijt LS, Prins JB, Leenen PJ, Thielemans K, de Vries VC, Hoogsteden HC et al. Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in amouse model of asthma. Blood 2002 100 : 3663 3671.
87. Huh JC, Strickland DH, Jahnsen FL, Turner DJ, Thomas JA, Napoli S et al. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 2003 198 : 19 30.
88. Lambrecht BN, Salomon B, Klatzmann D, Pauwels RA. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol 1998 160 : 4090 4097.
89. van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, Duez C et al. In vivo depletion of lung CDllc+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 2005 201 : 98I 991.
90. Henz BM, Maurer M, Lippert U, Worm M, Babina M. Mast cells as initiators of immunity and host defense. ExpDermatol 2001 10 : l 10.
91. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005 6 : 135 142.
92. Malaviya R, Twesten NJ, Ross EA, Abraham SN, Pfeifer JD. Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. J Immunol 1996 156 : 1490 1496.
93. Frandji P, Oskeritzian C, Cacaraci F, Lapeyre J, Peronet R, David B et al. Antigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma. J Immunol 1993 151 : 6318 6328.
94. Maurer M, Echtenacher B, Hultner L, Kollias G, Mannel DN, Langley KE et al. The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells. J Exp Med 1998 188 : 2343 2348.
95. Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 2004 432 : 512 516.
96. Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol 2004 4 : 787 799.
97. Williams CM, Galli SJ. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000 192 : 455 462.
98. Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG et al. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997 186 : 449 454.
99. Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004 21 : 733 741.
100. Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M et al. Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci USA 2006 103 : 2286 2291.
101. Steinman RM, Inaba K. Myeloid dendritic cells. J Leukoc Biol 1999 66 : 205 208.
102. Cumberbatch M, Dearman RJ, Griffiths CE, Kimber I. Langerhans cell migration. Clin Exp Dermatol 2000 25 : 413 418.
103. Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses. Adv Exp Med Biol 1997 417 : 363 367.
104. Faveeuw C, Gosset P, Bureau F, Angeli V, Hirai H, Maruyama T et al. Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. Eur J Immunol 2003 33 : 889 898.
105. Gosset P, Bureau F, Angeli V, Pichavant M, Faveeuw C, Tonnel AB et al. Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. J Immunol 2003 170 : 4943 4952.
106. Mekori YA, Metcalfe DD. Mast cell-T cell interactions. J Allergy Clin Immunol 1999 104 : 517 523.
107. Korsgren M, Erjefalt JS, Korsgren O, Sundler F, Persson CG. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J Exp Med 1997 185 : 885 892.
108. Mehlhop PD, van de Rijn M, Goldberg AB, Brewer JP, Kurup VP, Martin TR et al. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A 1997 94 : 1344 1349.
109. Yu M, Tsai M, Tarn SY, Jones C, Zehnder J, Galli SJ. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006 116 : 1633 1641.
110. Persson CG, Erjefalt JS, Korsgren M, Sundler F. The mouse trap. Trends Pharmacol Sci 1997 18 : 465 467.
111. Corry DB, Folkesson HG, Warnock ML, Erie DJ, Matthay MA, Wiener-Kronish JP et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 1996 183 : 109 117.
112. Lefort J, Bachelet CM, Leduc D, Vargaftig BB. Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness. J Allergy Clin Immunol 1996 97 : 788 799.
113. Korsgren M, Persson CG, Sundler F, Bjerke T, Hansson T, Chambers BJ et al. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J Exp Med 1999 189 : 553 562.
114. Qiao H, Andrade MV, Lisboa FA, Morgan K, Beaven MA. FcepsilonRl and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood 2006 107 : 610 618.
115. Jung YW, Schoeb TR, Weaver CT, Chaplin DD. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 2006 168 : 1425 1434.