Immunomodulatory Effects of IL-12 on Allergic Lung Inflammation Depend on Timing of Doses

Journal of Immunology

Volumn 157, Issue 9, 1996, Pages 4173-4180

  Sur, Sanjiv ^a   Lam, Johnsimon ^a   Bouchard, Page ^b   Sigounas, Anastasia ^a   Holbert, Donald ^a   Metzger, W James ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALLERGEN; CYTOKINE; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNIZATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LUNG; LUNG LAVAGE; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; POLLEN; RESPIRATORY TRACT ALLERGY; SECRETION; TH1 CELL; TH2 CELL; TRACHEA;

ACETYLCHOLINE; ADJUVANTS, IMMUNOLOGIC; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENE EXPRESSION REGULATION; IMMUNIZATION; IMMUNOGLOBULIN E; IMMUNOLOGIC MEMORY; INTERLEUKIN-12; LUNG; MICE; MICE, INBRED BALB C; POLLEN; RESPIRATORY HYPERSENSITIVITY; TH1 CELLS; TH2 CELLS; TRACHEA;

EID: 0030293642     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil recruitment into mouse trachea. Am. Rev. Respir. Dis. 146:374.
2. + T-lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 10:587.
3. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A. J. Wardlaw, C. J. Corrigan, B. Bradley, S. R. Durham, J. V. Collins, P. K. Jeffrey, and A. B. Kay. 1991. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541.
4. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
5. + T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol. 92:313.
6. Brusselle, G. G., J. C. Kips, J. H. Tavernier, J. G. Van Der Hyden, C. A. Cuvelier, R. A. Pauwells, and H. Bleuthmann. 1993. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 24:73.
7. Brusselle, G., G. J. Kips, H. Bluethmann, and R. Pauwels. 1995. Allergen-induced airway inflammation and bronchial responsiveness in wild type and interleukin-4 deficient mice. Am. J. Respir. Cell. Mol. Biol. 12:254.
8. Coyle, A. J., G. L. Gros, C. Bertrand, S. Tsuyuki, C. H. Heusser, M. Kopf, and G. P. Anderson. 1995. Inlerleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell. Mol. Biol. 13:54.
9. Lukacs, N. W., R. M. Strieter, S. W. Chensue, and S. L. Kunkel. 1994. Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell. Mol. Biol. 10:526.
10. Corry, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Weiner-Kronish, and R. M. Locksley. 1996. Interleukin-4, but not interleukin-5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109.
11. Ohnishi, T., S. Sur, D. S. Collins, J. E. Fish, G. J. Gleich, and S. P. Peters. 1993. Eosinophil survival activity identified as interleukin-5 is associated with eosinophil recruitment and degranulation and lung injury twenty-four hours after segmentai antigen lung challenge. J. Allergy Clin. Immunol. 92:607.
12. Ohnishi, T., H. Kita, D. Weiler, S. Sur, J. B. Sedgwick, W. J. Calhoun, W. W. Busse, J. S. Abrams, and G. J. Gleich. 1993. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. Am. Rev. Respir. Dis. 147:901.
13. Sur, S., G. J. Gleich, M. Swanson, K. R. Bartemes, and D. H. Broide. 1995. Eosinophilic inflammation is associated with elevation of IL-5 in the airways of patients with spontaneous symptomatic asthma. J. Allergy Clin. Immunol. 96:661.
14. Sur, S., G. J. Gleich, K. P. Offord, M. C. Swanson, T. Ohnishi, L. B. Martin, J. M. Wagner, D. A. Weiler, and L. W. Hunt. 1995. Allergen challenge in asthma: association of eosinophils and lymphocytes with IL-5. Allergy 50:891.
15. Sur, S., H. Kita, G. J. Gleich, T. C. Chenier, and L. W. Hunt. 1996. Eosinophil recruitment is associated with IL-5 but not with RANTES 24 hours after allergen challenge. J. Allergy Clin. Immunol. 97:1272.
16. Kung, T. T., D. M. Slelts, J. A. Zurcher, G. K. Adams, R. W. Egan, W. Kreutner, A. S. Watnick, H. Jones, and R. W. Chapman. 1995. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am. J. Respir. Cell. Mol. Biol. 13:360.
17. Mauser, P. J., A. M. Pitman, X. Fernandez, S. K. Foran, G. K. Adams, W. Kreutner, R. W. Egan, and R. W. Chapman. 1995. Effect of an antibody to IL-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 152:467.
18. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin-5 deficiency abolishes eosinophilia, airway hypereactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195.
19. Nakajima, H., I. Iwamoto, and S. Yoshida. 1993. Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. Am. Rev. Respir. Dis. 143:1102.
20. + T-cells. J. Exp. Med. 177:573.
21. + T cells through IL-12 produced by Listeria-induced macrophages [see comments]. Science 260:547.
22. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
23. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172.
24. Afonso, L. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
25. Oswald, I. P., P. Caspar, D. Jankovic, T. A. Wynn, E. J. Pearce, and A. Sher. 1994. IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J. Immunol. 153:1707.
26. Gavett, S. H., D. J. O'Hearn, L. Xiumin, S. K. Huang, F. D. Finkelman, and M. Wills-Karp. 1995. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527.
27. Wynn, T. A., D. Jankovic, S. Hieny, A. W. Cheever, and A. Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J. Immunol. 154:4701.
28. + T lymphocytes. J. Immunol. 155:111.
29. Kung, T. T., D. Stelts, J. A. Zurcher, H. Jones, S. P. Umland, W. Kreutner, R. W. Egan, and R. W. Chapman. 1995. Mast cells modulate allergic pulmonary eosinophilia in mice. Am. J. Respir. Cell. Mol. Biol. 12:404.
30. Hunt, L. W., G. J. Gleich, T. Ohnishi, D. A. Weiler, E. S. Mansfield, H. Kita, and S. Sur. 1994. Endotoxin contamination causes neutrophilia following pulmonary allergen challenge. Am. J. Respir. Crit. Care Med. 149:1471.
31. Kung, T. T., H. Jones, G. K. Adams, S. P. Umland, W. Kreutner, R. W. Egan, R. W. Chapman, and A. S. Watnick. 1994. Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105:83.
32. Renz, H., G. Lack, J. Saloga, R. Schwinzer, K. Bradley, J. Loader, A. Kupfer, C. L. Larsen, and E. W. Gelfand. 1994. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J. Immunol. 152:351.
33. Renz, H., J. Saloga, K. L. Bradley, J. E. Loader, J. L. Greenstein, G. Larsen, and E. W. Gelfand. 1993. Specific V beta T cell subsets mediate the immediate hypersensitivity response to ragweed allergen. J. Immunol. 151:1907.
34. Ali, S., S. J. Mustafa, and W. J. Metzger. 1994. Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor. J. Phamacol. Exp. Ther. 268:1328.
35. Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047.
36. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 1994:1551.
37. Solley, G. O., G. J. Gleich, R. E. Jordan, and A. L. Schroeter. 1976. The late phase of the immediate wheal and flare skin reaction: its dependence upon IgE antibodies. J. Clin. Invest. 58:408.
38. Dolovich, J., F. E. Hargreave, R. Chalmers, K. J. Shier, S. J. Gauldie, and J. Bienenstock. 1973. Late cutaneous responses in isolated IgE-dependent reactions. J. Allergy Clin. Immunol. 52:38.
39. Leiferman, K. M., T. Fujisawa, B. H. Gray, and G. J. Gleich. 1990. Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction. Lab. Invest. 62:579.
40. + T cell recruitment into tissue. J. Immunol. 153:1264.
41. Bentley, A. M., Q. Meng, D. S. Robinson, Q. Hamid, A. B. Kay, and S. R. Durham. 1993. Increase in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen in atopic asthma. Am. J. Respir. Cell. Mol. Biol. 8:35.
42. Sedgwick, J. B., W. J. Calhoun, G. J. Gleich, H. Kita, J. S. Abrams, L. B. Schwartz, B. Volovitz, Y. M. Ben, and W. W. Busse. 1991. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge: characterization of eosinophil and mast cell mediators. Am. Rev. Respir. Dis. 144:1274.
43. Zuany-Amoim, C., S. Haile, D. Leduc, C. Dumarey, M. Huerre, B. Vargaftig, and M. Pretolani. 1995. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95:2644.
44. Kips, J. C., G. J. Brusselle, G. F. Joos, R. A. Peleman, J. H. Tavernier, R. R. Devos, and R. A. Pauwels. 1996. IL-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 153:535.
45. Wardlaw, A. J., S. Dunnette, and G. J. Gleich. 1988. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: relationship to bronchial hyperreactivity. Am. Rev. Respir. Dis. 137:62.
46. Bradley, B. L., M. Azzawi, M. Jacobson, B. Assoufi, J. V. Collins, A. M. Irani, L. B. Schwartz, S. R. Durham, P. K. Jeffery, and A. B. Kay. 1991. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 88:661.
47. Jeffery, P. K. 1994. Comparative morphology of the airways in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 150:56.
48. Gundel, R. H., M. E. Gerritsen, G. J. Gleich, and C. D. Wegner. 1990. Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates. J. Appl. Physiol. 68:779.
49. Maestrelli, P., M. Saetta, S. A. Di, P. G. Calcagni, G. Turato, M. P. Ruggieri, A. Roggeri, C. E. Mapp, and L. M. Fabbri. 1995. Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage. Am. J. Respir. Crit. Care Med. 152:1926.
50. Wang, Z., S. Zheng, D. B. Corry, D. K. Dalton, R. A. Seder, S. L. Reiner, and R. M. Locksley. 1994. Interferon-γ independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 91:12932.
51. Yanagida, T., T. Kato, O. Igarashi, T. Inoue, and H. Nariuchi. 1994. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone. J. Immunol. 152:4919.
52. Bliss, J., V. Van Cleave, K. Murray, A. Weincis, M. Ketchum, R. Maylor, T. Haire, C. Resmini, A. K. Abbas, and S. F. Wolf. 1996. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 recall response. J. Immunol. 156:887.
53. Cohen, J. 1995. IL-12 deaths: explanation and a puzzle. Science 270:908.