Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: Involvement of CCR7

Journal of Immunology

Volumn 169, Issue 3, 2002, Pages 1524-1534

  Hammad, Hamida ^a   Lambrecht, Bart N ^a   Pochard, Pierre ^a   Gosset, Philippe ^a   Marquillies, Philippe ^a   Tonnel, André Bernard ^a   Pestel, Joël ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES PTERONYSSINUS; EFFECTOR CELL; EOSINOPHIL; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; LUNG LAVAGE; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MEDIASTINUM LYMPH NODE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE;

EID: 0036681956     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.3.1524     Document Type: Article

References (40)

1. Dendritic cells and the control of immunity
2. Allergen uplake and presentation by dendritic cells
3. Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm
4. Human lung dendritic cells hate an immature phenotype with efficient mannose receptors
5. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs
6. Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model
7. Sensitization to inhaled antigen by intratracheal instillation of dendritic cells
8. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
9. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: More similarities than differences
10. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
11. Human IgE in SCID mice reconstituted with peripheral blood mononuclear cells from Dermatophagoides pteronyssinus-sensitive patients
12. An in vivo model of allergic inflammation: Pulmonary human cell infiltrate in allergen-challenged allergic Hu-SCID mice
13. Allergen-induced migration of human cells in allergic severe combined immunodeficiency mice
14. Human dendritic cells in the severe combined immunodeficiency mouse model: Their potentiating role in the allergic reaction
15. House dust mite-induced airway changes in hu SCID mice
16. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
17. Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix
18. Determination of lymphocyte division by flow cytometry
19. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
20. + dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen
21. Migration of dendritic cells into the draining lymph nodes of the lung after intratracheal instillation
22. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways
23. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
24. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
25. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
26. Th2 polarization by Der p I-pulsed monocyte-derived dendritic cells is due to the allergic status of the donors
27. Helper T-cell responses elicited by Der p 1-pulsed dendritic cells and recombinant IL-12 in atopic and healthy subjects
28. Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors
29. Inhalant allergen-specific T-cell reactivity is detectable in close to 1005% of atopic and normal individuals: Covert responses are unmasked by serum-free medium
30. The interplay between the duration of TCR and cytokine signaling determines T cell polarization
31. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
32. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
33. Eosinophitic inflammation in asthma
34. Naive and memory T cells show distinct pathways of lymphocyte recirculation
35. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vitro- and in vivo-derived dendritic cells
36. Cutting edge: Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes
37. Inhibition of functional T cell priming and contact hypersensitivity responses by treatment with anti-secondary lymphoid chemokine antibody during hapten sensitization
38. 4 transporter MRP1 regulates CCL19 (MIP-3β, ELC)-dependent mobilization of dendritic cells to lymph nodes
39. Mice lacking expression of the chemokines cc121-ser and cc119 (plt mice) demonstrate delayed but enhanced T cell immune responses
40. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions