Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells

Nature Immunology

Volumn 5, Issue 3, 2004, Pages 337-343

  Dahl, Martin E ^a   Dabbagh, Karim ^a,c   Liggitt, Denny ^b   Kim, Sung ^a   Lewis, David B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNOREGULATION; IN VIVO STUDY; INFLAMMATION; INFLUENZA VIRUS A; INTERFERON PRODUCTION; LUNG ALVEOLUS CELL; LUNG DISEASE; LUNG FUNCTION; MOUSE; NONHUMAN; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; TH1 CELL; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; IMMUNOLOGY; LUNG; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT ALLERGY;

ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; INFLUENZA A VIRUS; INTERFERON TYPE II; LUNG; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; RESPIRATORY HYPERSENSITIVITY; TH1 CELLS; TH2 CELLS;

EID: 1542347573     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1041     Document Type: Article

References (49)

1. Holgate, S.T. The epidemic of allergy and asthma. Nature 402, B2-4 (1999).
2. Gern, J.E. & Busse, W.W. Relationship of viral infections to wheezing illnesses and asthma. Nat. Rev. Immunol. 2, 132-138 (2002).
3. Redd, S.C. Asthma in the United States: burden and current theories. Environ. Health Perspect. 110, 557-560 (2002).
4. Wills-Karp, M., Santeliz, J. & Karp, C.L. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat. Rev. Immunol. 1, 69-75 (2001).
5. Morel, P.A. & Criss, T.B. Crossregulation between Th1 and Th2 cells. Crit. Rev. Immunol. 18, 275-303 (1998).
6. Erb, K.J., Holloway, J.W., Sobeck, A., Moll, H. & Le Gros, G. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J. Exp. Med. 187, 561-569 (1998).
7. Lewis, D.B. Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Curr. Opin. Immunol. 14, 644-651 (2002).
8. Schwarze, J. & Gelfand, E.W. Respiratory viral infections as promoters of allergic sensitization and asthma in animal models. Eur. Respir. J. 19, 341-349 (2002).
9. Martinez, F.D. What have we learned from the Tucson Children's Respiratory Study? Paediatr. Respir. Rev. 3, 193-197 (2002).
10. Schwarze, J., Hamelmann, E., Bradley, K.L., Takeda, K. & Gelfand, E.W. Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J. Clin. Invest. 100, 226-233 (1997).
11. + T-cell mechanisms in the control of respiratory virus infections. Immunol. Rev. 159, 105-117 (1997).
12. Roman, E. et al. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196, 957-968 (2002).
13. + T cell population isolated from an effector site contains cells with flexible cytokine profiles. J. Exp. Med. 190, 1081-1092 (1999).
14. 2-Microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype. J. Immunol. 153, 1246-1253 (1994).
15. Graham, M.B. et al. Response to influenza infection in mice with a targeted disruption in the interferon γ gene. J. Exp. Med. 178, 1725-1732 (1993).
16. Eichelberger, M.C., Wang, M.L., Allan, W., Webster, R.G. & Doherty, P.C. Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted mice. J. Gen. Virol. 72, 1695-1698 (1991).
17. Lloyd, C.M., Gonzalo, J.A., Coyle, A.J. & Gutierrez-Ramos, J.C. Mouse models of allergic airway disease. Adv. Immunol. 77, 263-295 (2001).
18. Finkelman, F.D. et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8, 303-333 (1990).
19. Coffman, R.L., Lebman, D.A. & Rothman, P. Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54, 229-270 (1993).
20. Lambrecht, B.N. et al. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. 106, 551-559 (2000).
21. Julia, V. et al. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity 16, 271-283 (2002).
22. H1 polarization. Nat. Immunol. 1, 305-310 (2000).
23. Brimnes, M.K., Bonifaz, L., Steinman, R.M. & Moran, T.M. Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J. Exp. Med. 198, 133-144 (2003).
24. Kolopp-Sarda, M.N., Bene, M.C., Massin, N., Moulin, J.J. & Faure, G.C. Immunohistological analysis of macrophages, B-cells, and T-cells in the mouse lung. Anat. Rec. 239, 150-157 (1994).
25. Huang, S. et al. Immune response in mice that lack the interferon-γ receptor. Science 259, 1742-1745 (1993).
26. lo thymocytes in vivo. Science 250, 1720-1723 (1990).
27. Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133-146 (2003).
28. Hansen, G., Berry, G., DeKruyff, R.H. & Umetsu, D.T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175-183 (1999).
29. Randolph, D.A., Stephens, R., Carruthers, C.J. & Chaplin, D.D. Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. J. Clin. Invest. 104, 1021-1029 (1999).
30. Mo, X.Y., Sarawar, S.R. & Doherty, P.C. Induction of cytokines in mice with parainfluenza pneumonia. J. Virol. 69, 1288-1291 (1995).
31. Hussell, T., Spender, L.C., Georgiou, A., O'Garra, A. & Openshaw, P.J. Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus. J. Gen. Virol. 77, 2447-2455 (1996).
32. Schwarze, J. et al. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J. Immunol. 162, 2997-3004 (1999).
33. Schwarze, J. et al. CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. J. Immunol. 162, 4207-4211 (1999).
34. Schwarze, J. et al. Transfer of the enhancing effect of respiratory syncytial virus infection on subsequent allergic airway sensitization by T lymphocytes. J. Immunol. 163, 5729-5734 (1999).
35. Wohlleben, G. et al. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. J. Immunol. 170, 4601-4611 (2003).
36. Kuchroo, V.K., Umetsu, D.T., DeKruyff, R.H. & Freeman, G.J. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3, 454-462 (2003).
37. Krug, N. et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am. J. Respir. Cell. Mol. Biol. 14, 319-326 (1996).
38. ten Hacken, N.H. et al. Elevated serum interferon-γ in atopic asthma correlates airways responsiveness and circadian peak expiratory flow variation. Eur. Respir. J. 11, 312-316 (1998).
39. Sampath, D., Castro, M., Look, D.C. & Holtzman, M.J. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J. Clin. Invest. 103, 1353-1361 (1999).
40. + T cells in asthma. Am. J. Respir. Crit. Care Med. 161, 1790-1796 (2000).
41. Yamamoto, N. et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur. J. Immunol. 30, 316-326 (2000).
42. Yamamoto, N. et al. Immune response induced by airway sensitization after influenza A virus infection depends on timing of antigen exposure in mice. J. Virol. 75, 499-505 (2001).
43. Kamath, A.T., Henri, S., Battye, F., Tough, D.F. & Shortman, K. Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 100, 1734-1741 (2002).
44. Cherwinski, H.M., Schumacher, J.H., Brown, K.D. & Mosmann, T.R. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166, 1229-1244 (1987).
45. Tsitoura, D.C. et al. Respiratory infection with influenza A virus interferes with of tolerance to aeroallergens. J. Immunol. 165, 3484-3491 (2000).
46. Dabbagh, K. et al. Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI. J. Immunol. 165, 3418-3422 (2000).
47. Dabbagh, K., Dahl, M.E., Stepick-Biek, P. & Lewis, D.B. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 168, 4524-4530 (2002).
48. Lyons, A.B., Hasbold, J. & Hodgkin, P.D. Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succinimidyl ester, a stably integrated fluorescent probe. Methods Cell Biol. 63, 375-398 (2001).
49. Marrack, P., Shimonkevitz, R., Hannum, C., Haskins, K. & Kappler, J. The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J. Exp. Med. 158, 1635-1646 (1983).