Specific antibody responses to subtilisin Carlsberg (Alcalase) in mice: Development of an intranasal exposure model

Fundamental and Applied Toxicology

Volumn 34, Issue 1, 1996, Pages 15-24

  Robinson, Michael K ^a   Babcock, Laura S ^a   Horn, Patricia A ^a   Kawabata, Thomas T ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUBTILISIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GUINEA PIG; IMMUNOGENICITY; MODEL; MOUSE; NONHUMAN;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 85033053188     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0171     Document Type: Article

References (62)

1. Beck, L., and Spiegelberg, H. L. (1989). The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund's adjuvant. Cell. Immunol. 123, 1-8.
2. Berzofsky, J. A., Schechter, A. N., Shearer, G. M., and Sachs, D. H. (1977). Genetic control of the immune response to staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments. J. Exp. Med. 145, 111-122.
3. Brusselle, G., Kips, J., Joos, G., Bluethmann, H., and Pauwels, R. (1995). Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 12, 254-259.
4. Butler, J. E., and Hamilton, R. G. (1991). Quantitation of specific antibodies: Methods of expression, standards, solid-phase considerations, and specific applications. In Immunochemistry of Solid-Phase Immunoassays (J. E. Butler, Ed.), pp. 173-198. CRC Press, Boca Raton, FL.
5. Cashner, F., Schuyler, M., Fletcher, R., Ritz, H., and Salvaggio, J. (1980). Immunologic responses of cynomologus monkeys after repeated inhalation exposures to enzymes and enzyme-detergent mixtures. Toxicol. Appl. Pharmacol. 52, 62-68.
6. Else, K., and Wakelin, D. (1989). Genetic variation in the humoral immune responses of mice to the nematode Trichuris muris. Parasite Immunol. 11, 77-90.
7. Enander, I., Ahlstedt, S., and Nygren, H. (1985). Regional and systemic immune responses to trinitrophenyl derivatives after intranasal and subcutaneous sensitization of mice. J. Allergy Clin. Immunol. 75, 37-43.
8. Fokkens, W. J., Vroom, T. M., Rijntjes, E., and Mulder, P. G. (1989). CD-1 (T6), HLA-DR-expressing cells, presumably Langerhans cells, in nasal mucosa. Allergy 44, 167-172.
9. Fujiwara, M., Fujiwara, S., Yoshizaki, C., and Awaya, A. (1976). Strain differences in the immunogenicity of aggregated human IgG and the adjuvant action of lipopolysaccharide on the low-responder strain of mice. Jpn. J. Microbiol. 20, 141-146.
10. Garcia, V. E., Gherardi, M. M., Iglesias, M. F., Cerquetti, M. C., and Sordelli, D. O. (1993). Local and systemic immunity against Streptococcus pneumoniae: Humoral responses against a non-capsulated temperature-sensitive mutant. FEMS Microbiol. Lett. 108, 163-167.
11. Garcia, V. E., Iglesias, M. F., Cerquetti, M. C., Gomez, M. I., and Sordelli, D. O. (1994). Interaction between granulocytes and antibodies in the enhancement of lung defenses against Staphylococcus aureus after intranasal immunization of mice with live-attenuated bacteria. FEMS Immunol. Med. Microbiol. 9, 55-63.
12. Garlisi, C. G., Falcone, A., Kung, T. T., Stelts, D., Pennline, K. J., Beavis, A. J., Smith, S. R., Egan, R. W., and Umland, S. P. (1995). T cells are necessary for Th-2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin. Immunol. Immunopathol. 75, 75-83.
13. Gurvich, A. E., and Korukova, A. (1986). Induction of abundant antibody formation with a protein-cellulose complex in mice. J. Immunol. Methods 87, 161-167.
14. Hameleers, D. M., van der Ven, I., Biewenga, J., and Sminia, T. (1991). Mucosal and systemic antibody formation in the rat after intranasal administration of three different antigens. Immunol. Cell Biol. 69, 119-125.
15. Henderson, D. C., Moran, D. M., and Wheeler, A. W. (1985). Differential suppressive influence of intranasal application of rye grass pollen extract on IgE antibody production in the mouse. Clin. Exp. Immunol. 59, 343-350.
16. Henderson, D. C., Wheeler, A. W., and Moran, D. M. (1987). Suppression of murine IgE responses with amino acid polymer/allergen conjugates. V. By intranasal administration. Int. Arch. Allergy Appl. Immunol. 82, 208-211.
17. Hilton, J., Dearman, R. J., Basketter, D. A., and Kimber, I. (1994). Serological responses induced in mice by immunogenic proteins and by protein respiratory allergens. Toxicol. Lett. 73, 43-53.
18. Holt, P. G., Batty, J. E., and Turner, K. J. (1981a). Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology 42, 409-417.
19. Holt, P. G., Rose, A. H., Batty, J. E., and Turner, K. J. (1981b). Induction of adjuvant-independent IgE responses in inbred mice: Primary, secondary, and persistent IgE responses to ovalbumin and ovomucoid. Int. Arch. Allergy Appl. Immunol. 65, 42-50.
20. Holt, P. G., Schon Hegrad, M. A., and Oliver, J. (1988). MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J. Exp. Med. 167, 262-274.
21. Holt, P. G., Schon Hegrad, M. A., Phillips, M. J., and McMenamin, P. G. (1989). Ia-positive dendritic cells from a tightly meshed network within the human airway epithelium. Clin. Exp. Allergy 19, 597-601.
22. Horn, P. A., Babcock, L. S., Kawabata, T. T., and Robinson, M. K. (1996). Further development and characterization of a mouse intranasal method for comparative immunogenicity testing of enzymes. Fundam. Appl. Toxicol. 30, 95. [Abstract]
23. Inagaki, N., Tsuruoka, N., Goto, S., Matsuyama, T., Daikoku, M., Nagai, H., and Koda, A. (1985). Immunoglobulin E antibody production against house dust mite, Dermatophagoides farinae, in mice. J. Pharmacobiodyn. 8, 958-963.
24. Kawabata, T. T., and Babcock, L. S. (1993). Measurement of murine ovalbumin-specific IgE by a rat basophil leukemia cell serotonin release assay. Comparison to the rat passive cutaneous anaphylaxis assay. J. Immunol. Methods 162, 9-15.
25. Kawabata, T. T., Babcock, L. S., Gauggel, D. L., Asquith, T. N., Fletcher, E. R., Horn, P. A., Ratajczak, H. V., and Graziano, F. M. (1995a). Optimization and validation of an ELISA to measure specific guinea pig IgG1 antibody as an alternative to the in vivo passive cutaneous anaphylaxis assay. Fundam. Appl. Toxicol. 24, 238-246.
26. Kawabata, T. T., Horn, P. A., and Babcock, L. S. (1995b). Development of a mouse intranasal model to assess the immunogenicity of proteins. Toxicologist 15, 99. (Abstract)
27. Kawabata, T. T., Babcock, L. S., and Horn, P. A. (1996). Specific IgE and IgG1 responses to subtilisin Carlsberg (alcalase) in mice: Development of an intratracheal exposure model. Fundam. Appl. Toxicol. 29, 238-243.
28. Kimber, I., Bernstein, I. L., Karol, M. H., Robinson, M. K., Sarlo, K., and Selgrade, M. K. (1996). Identification of respiratory allergens. Fundam. Appl. Toxicol. 33, 1-10.
29. Kudo, K., Okudaira, H., Miyamoto, T., Nakagawa, T., and Horiuchi, Y. (1978). IgE antibody response to mite antigen in the mouse. Suppression of an established IgE antibody response by chemically modified antigen. J. Allergy Clin. Immunol. 61, 1-9.
30. Kung, T. T., Jones, H., Adams, G. K., Umland, S. P., Kreutner, W., Egan, R. W., Chapman, R. W., and Watnick, A. S. (1994a). Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105, 83-90.
31. Kung, T. T., Stelts, D., Zurcher, J. A., Watnick, A. S., Jones, H., Mauser, P. J., Fernandez, X., Umland, S., Kreutner, W., Chapman, R. W., and Egan, R. W. (1994b). Mechanisms of allergic pulmonary eosinophilia in the mouse. J. Allergy Clin. Immunol. 94, 1217-1224.
32. Lei, H.-Y., Lee, S.-H., and Leir, S.-H. (1996). Antigen-induced anaphylactic death in mice. Int. Arch. Allergy Appl. Immunol. 109, 407-412.
33. Lukacs, N. W., Strieter, R. M., Chensue, S. W., and Kunkel, S. L. (1994). Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Molec. Biol. 10, 526-532.
34. Mancino, D., and Ovary, Z. (1980). Adjuvant effects of amorphous silica and of aluminium hydroxide on IgE and IgG1 antibody production in different inbred mouse strains. Int. Arch. Allergy Appl. Immunol. 61, 253-258.
35. Markham, R. J., and Wilkie, B. N. (1976). Influence of detergent on aerosol allergic sensitization with enzymes of Bacillus subtilis. Int. Arch. Allergy Appl. Immunol. 51, 529-543.
36. Markham, R. J., and Wilkie, B. N. (1979). Effect of detergent on protease-induced mortality and pulmonary histopathology. Arch. Environ. Health 34, 418-423.
37. McCaskill, A. C., Hosking, C. S., and Hill, D. J. (1982). IgE and haemagglutinating antibody production in mice following intranasal immunization with ryegrass pollen. Int. Arch. Allergy Appl. Immunol. 67, 191-193.
38. McCaskill, A. C., Hosking, C. S., and Hill, D. J. (1984). Anaphylaxis following intranasal challenge of mice sensitized with ovalbumin. Immunology 51, 669-677.
39. Muller, C. P., and Brons, N. H. (1994). Systemic B-cell response in the mouse after mucosal immunization with measles virus. Immun. Infekt. 22, 125-126.
40. Nakashima, S., Kamikawa, H., and Ogita, Z. (1983). Isoelectric focusing of the inbred mouse antibody to bacterial alpha-amylase. J. Biochem. 94, 1723-1730.
41. Nomoto, K., Mashiba, H., and Takeya, K. (1972). Immune response against hamster erythrocytes in the low-responder mouse strains. I. Strain difference in the antibody response to primary antigenic stimulation and its disappearance after pre-sensitization with the antigen in Freund's complete adjuvant. Jpn. J. Microbiol. 16, 43-51.
42. Oettgen, H. C., Martin, T. R., Wynshaw-Boris, A., Deng, C., Drazen, J. M., and Leder, P. (1994). Active anaphylaxis in IgE-deficient mice. Nature 370, 367-370.
43. Oien, N. L., Brideau, R. J., Walsh, E. E., and Wathen, M. W. (1994). Induction of local and systemic immunity against human respiratory syncytial virus using a chimeric FG glycoprotein and cholera toxin B subunit. Vaccine 12, 731-735.
44. Oshiba, A., Hamelmann, E., Takeda, K., Bradley, K. L., Loader, J. E., Larsen, G. L., and Gelfand, E. W. (1996). Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig)E and IgG1 in mice. J. Clin. Invest. 97, 1398-1408.
45. Petty, R. E., and Steward, M. W. (1977). The effect of immunological adjuvants on the relative affinity of anti-protein antibodies. Immunology 32, 49-55.
46. Purkerson, J. M., and Isakson, P. C. (1992). Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE. J. Exp. Med. 175, 973-982.
47. Revoltella, R., and Ovary, Z. (1969). Reaginic antibody production in different mouse strains. Immunology 17, 45-54.
48. Ritz, H. L., Evans, B. L., Bruce, R. D., Fletcher, E. R., Fisher, G. L., and Sarlo, K. (1993). Respiratory and immunological responses of guinea pigs to enzyme-containing detergents: A comparison of intratracheal and inhalation modes of exposure. Fundam. Appl. Toxicol. 21, 31-37.
49. Santing, R. E., Olymulder, C. G., Zaagsma, J., and Meurs, H. (1994). Relationships among allergen-induced early and late phase airway obstructions, bronchial hyperreactivity, and inflammation in conscious, unrestrained guinea pigs. J. Allergy Clin. Immunol. 93, 1021-1030.
50. Sarlo, K., Polk, J. E., and Ritz, H. L. (1991). Guinea pig intratracheal test to assess respiratory allergenicity of detergent enzymes; comparison with the human data base. J. Allergy Clin. Immunol. 87, 816. [Abstract]
51. Sarlo, K., and Karol, M. H. (1994). Guinea pig predictive tests for respiratory allergy. In Immunotoxicology and Immunopharmacology (J. H. Dean, M. I., Luster, A. E. Munson, and I. Kimber, Eds.), Vol. 2, pp. 703-720. Raven Press, New York.
52. Starcher, B., and Williams, I. (1989). A method for intratracheal instillation of endotoxin into the lungs of mice. Lab. Anim. 23, 234-240.
53. Staruch, M. J., and Wood, D. D. (1982). Genetic influences on the adjuvanticity of muramyl dipeptide in vivo. J. Immunol. 128, 155-160.
54. Takafuji, S., Suzuki, S., Koizumi, K., Tadokoro, K., Miyamoto, T., Ikemori, R., and Muranaka, M. (1987). Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. J. Allergy Clin. Immunol. 79, 639-645.
55. Takafuji, S., Suzuki, S., Koizumi, K., Tadokoro, K., Ohashi, H., Muranaka, M., and Miyamoto, T. (1989). Enhancing effect of suspended particulate matter on the IgE antibody production in mice. Int. Arch. Allergy Appl. Immunol. 90, 1-7.
56. Tamura, S., Shoji, Y., Hasiguchi, K., Aizawa, C., and Kurata, T. (1994a). Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin. Vaccine 12, 1238-1240.
57. Tamura, S., Yamanaka, A., Shimohara, M., Tomita, T., Komase, K., Tsuda, Y., Suzuki, Y., Nagamine, T., Kawahara, K., Danbara, H., et al. (1994b). Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine. Vaccine 12, 419-426.
58. Taylor, W. A., Sheldon, D., and Francis, D. H. (1980). IgE antibody formation in BALB/c mice without adjuvant: Induction of responses to grass pollen extract and to a hapten-carrier conjugate. Immunology 39, 583-588.
59. Tomlinson, L. A., Christie, J. F., Fraser, E. M., McLaughlin, D., McIntosh, A. E., and Kennedy, M. W. (1989). MHC restriction of the antibody repertoire to secretory antigens, and a major allergen, of the nematode parasite Ascaris. J. Immunol. 143, 2349-2356.
60. Vaz, E. M., Vaz, N. M., and Levine, B. B. (1971). Persistent formation of reagins in mice injected with low doses of ovalbumin. Immunology 21, 11-15.
61. Walsh, E. E. (1994). Humoral, mucosal, and cellular immune response to topical immunization with a subunit respiratory syncytial virus vaccine. J. Infect. Dis. 170, 345-350.
62. Wang, J. M., Denis, M., Fournier, M., and Laviolette, M. (1994). Experimental allergic bronchopulmonary aspergillosis in the mouse: Immunological and histological features. Scand. J. Immunol. 39, 19-26.