CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 25302-25308

  Maroney, Anna C ^a   Finn, James P ^a   Connors, Thomas J ^a   Durkin, John T ^a   Angeles, Thelma ^a   Gessner, George ^a   Xu, Zhiheng ^b   Meyer, Sheryl L ^a   Savage, Mary J ^a   Greene, Lloyd A ^b   Scott, Richard W ^a   Vaught, Jeffry L ^a  

^a CEPHALON INC   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL CULTURE; CELLS; CHEMICAL ACTIVATION; SIGNALING;

EMBRYONIC CULTURES;

NEUROLOGY;

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ADENOSINE TRIPHOSPHATE; CEP 1347; JANUS KINASE; JNK1 PROTEIN; LEUCINE ZIPPER PROTEIN; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE 1; MIXED LINEAGE KINASE 2; MIXED LINEAGE KINASE 3; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; DUAL LEUCINE ZIPPER BEARING KINASE; ENZYME INHIBITOR; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL STRAIN COS7; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; IC 50; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN; CHEMICAL MODEL; CHO CELL; DRUG ANTAGONISM; HAMSTER; METABOLISM; RAT;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; JANUS;

ANIMALS; CARBAZOLES; CELL DEATH; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; ENZYME INHIBITORS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, CHEMICAL; PC12 CELLS; PROTEIN KINASE INHIBITORS; RATS;

EID: 0035816685     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011601200     Document Type: Article

References (75)

1. Cobb, M. H. (1999) Prog. Biophys. Mol. Biol. 71, 479-500
2. Tibbles, L. A., and Woodgett, J. R. (1999) Cell. Mol. Life. Sci. 55, 1230-1254
3. Mielke, K., and Herdegen, T. (2000) Prog. Neurobiol. 61, 45-60
4. Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R., and Johnson, E. M. (1994) J. Cell Biol. 127, 1717-1727
5. Schlingensiepen, K. H., Wallnik, F., Kunst, M., Schlingensiepen, R., Herdengen, T., and Brysch, W. (1994) Cell. Mol. Neurobiol. 14, 487-505
6. Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., and Lallemand, D., Yaniv, M., Rubin, L. L. (1995) Neuron 14, 927-939
7. Eilers, A., Whitfield, J., Babij, C., Rubin, L. L., and Ham, J. (1998) J. Neurosci. 18, 1713-1724
8. Yang, D. D., Kuan, C. Y., Whitmarsh, A. J., Rincón, M., Zheng, T. S., Davis, R. J., Rakic, P., and Flacell, R. A. (1997) Nature 389, 865-870
9. Behrens, A., Sibilia, M., and Wagner, E. F. (1999) Nat. Genet. 21, 326-329
10. Michel, P. P., Lamberg, N., and Ruberg, M. (1999) Clin. Neuropharmacol. 22, 137-150
11. Waggie, K. S., Kahle, P. J., and Tolwani, R. J. (1999) Lab. Anim. Sci. 49, 358-362
12. Robertson, G. S., Crocker, S. J., Nicholson, D. W., and Schulz, J. B. (2000) Brain Pathol. 10, 283-292
13. Deijard, B., Raingeaud, J., Barrett, T., Wu, I. H., Han, J., Ulevitch, R. J., and Davis, R. J. (1995) Science 267, 682-685
14. Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M., and Zon, L. I. (1994) Nature 372, 794-798
15. Lin, A., Minden, A., Martinetto, H., Claret, F. X., Lange-Carter, C., Mercurio, F., Johnson, G. L., and Karin, M. (1995) Science 268, 286-290
16. Lawler, S., Cuenda, A., Goedert, M., and Cohen, P. (1997) FEBS Lett. 414, 153-158
17. Lu, X., Nemoto, S., and Lin, A. (1997) J. Biol. Chem. 272, 24751-24754
18. Tournier, C., Whitmarsh, A., Cavanagh, J., Barrett, T., and Davis, R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7737-7342
19. Wu, A., Wu, J., Jacinto, E., and Karin, M. (1997) Mol. Cell. Biol. 17, 7407-7416
20. Foltz, I. N., Gerl, R. E., Wieler, J. S., Lyckach, M., Salmon, R. A., and Schrader, J. W. (1998) J. Biol. Chem. 273, 9344-9351
21. Kyriakis, J. M. (1999) J. Biol. Chem. 274, 5259-5262
22. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
23. Kanamoto, T., Mota, M., Takefa, K., Rubin, L., Miyazono, K., Ichijo, H., and Bazenet, C. (2000) Mol. Cell. Biol. 20, 196-204
24. Bazenet, C. E., Mota, M. A., and Rubin, L. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3984-3989
25. Kaneko, M., Saito, Y., Saito, H., Matsumoto, T., Matsuda, Y., Vaught, J. L., Dionne, C. A., Angeles, T. S., Glicksman, M. A., Neff, N. T., Rotella, D. P., Kauer, J. C., Mallamo, J. P., Hudkins, R. L., and Murakata, C. (1997) J. Med. Chem. 40, 1863-1869
26. Borasio, G. D., Horstmann, S., Anneser, J. M. H., Neff, N. T., and Glicksman, M. A. (1998) Neuroreport 9, 1435-1439
27. Maroney, A. C., Glicksman, M. A., Basma, A. N., Walton, K. M., Knight, E., Murphy, C. A., Bartlett, B. A., Finn, J. P., Angeles, T., Matsudam, Y., Neff, N. T., and Dionne, C. A. (1998) J. Neurosci. 18, 104-111
28. Maroney, A. C., Finn, J. P., Bozyczko-Coyne, D., O'Kane, T., Neff, N. T., Tolkovsky, A. M., Park, D. S., Yan, C. Y. I., Troy, C. M., and Greene, L. A. (1999) J. Neurochem. 73, 1901-1912
29. Glicksman, M. A., Chiu, A. Y., Dionne, C. A., Harty, M., Kaneko, M., Murakata, C., Oppenheim, R. W., Prevette, D., Sengelaub, D. R., Vaught, J. L., and Neff, N. T. (1998) J. Neurobiol. 35, 361-378
30. Saporito, M. S., Brown, E. R., Carswell, S., DiCamillo, A. M., Miller, M. S., Murakata, C., Neff, N. S., Vaught, J. L., and Haun, F. A. (1998) Neuroscience 86, 461-472
31. Saporito, M. S., Brown, E. M., Miller, M. S., and Carswell, S. (1999) J. Pharmacol. Exp. Ther. 288, 421-427
32. Saporito, M. S., Thomas, B. A., and Scott, R. W. (2000) J. Neurochem. 75, 1-9
33. Smith, D. B., and Johnson, K. S. (1988) Gene 67, 31-40
34. Hink, W. F. (1970) Nature 226, 466-467
35. Meyer, S. L., Lang, D. M., Forbes, M. E., Knight, E., Jr., Hirsch, J. D., Trusko, S. P., and Scott, R. W. (1994) J. Neurochem. 62, 825-833
36. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene 77, 51-59
37. Ichijo, H., Nishida, E., Irie, K., Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., and Gotoh, Y. (1997) Science 275, 90-94
38. Merritt, S. E., Mata, M., Nihalani, D., Zhu, C., Hu, X., and Holzman, L. B. (1999) J. Biol. Chem. 274, 10195-10202
39. Holzman, L. B., Merritt, S. E., and Fan, G. (1994) J. Biol. Chem. 269, 30808-30817
40. Dorow, D. S. Devereux, L., Tu, G. F., Price, G., Nicholl, J. K., Sutherland, G. R., and Simpson, R. J. (1995) Eur. J. Biochem. 234, 492-500
41. Dorow, D. S., Devereux, L., Dietzsch, E., and De Kretser, T. (1993) Eur. J. Biochem. 213, 701-710
42. Sakuma, H., Ikeda, A., Oka, S., Kozutsumi, Y., Zanetta, J. P., and Kawasaki, T. (1997) J. Biol. Chem. 272, 28622-28629
43. Ezoe, K., Lee, S. E., Strunk, K. M., and Spritz, R. A. (1994) Oncogene 9, 935-938
44. Maroney, A. C., Lipfert, L., Forbes, M. E., Glicksman, M. A., Neff, N. T., Siman, R., and Dionne, C. A. (1995) J. Neurochem. 64, 540-549
45. Pitt, A. M., and Lee, C. (1996) J. Biomol. Screening 1, 47-51
46. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138
47. Teramoto, H., Coso, O. A., Miyata, H., Igishi, T., Miki, T., and Gutkind, J. S. (1996) J. Biol. Chem. 271, 27225-27228
48. English, J., Pearson, G., Wilsbacher, J., Swantek, J., Karandikar, M., Xu, S., and Cobb, M. H. (1999) Exp. Cell Res. 253, 255-270
49. Kiefer, F., Tibbles, L. A., Anafi, M., Jansses, A., Zanke, B. W., Lassam, N., Pawson, T., Woodgett, J. R., and Iscove, N. N. (1996) EMBO J. 15, 7013-7025
50. Hu, M. C. T., Qiu, W. R., Wang, X., Meyer, C. F., and Tan, R. H. (1996) Genes Dev. 10, 2251-2264
51. Nagata, K., Puls, A., Futter, C., Aspenstrom, P., Schaefer, E., Nakata, T., Hirokawa, N., and Hall, A. (1998) EMBO J. 17, 149-158
52. Liu, Y. F., Dorow, D., and Marshall, J. (2000) J. Biol. Chem. 275, 19035-19040
53. Hehner, S. P., Hofmann, T. G., Ushmorov, A., Dienz, O., Leung, I. W. L., Lassam, N., Scheidereit, C., Dröge, W., and Schmitz, M. L. (2000) Mol. Cell. Biol. 20, 2556-2568
54. Leung, I. W. L., and Lassam, N. (1998) J. Biol. Chem. 273, 32408-32415
55. Böck, B. C., Vacratsis, P. O., Qamirani, E., and Gallo, K. A. (2000) J. Biol. Chem. 275, 14231-14241
56. Nihalani, D., Merritt, S., and Holzman, L. B. (2000) J. Biol. Chem. 275, 7273-7279
57. Gallo, K. A., Mark, M. R., Scadden, D. T., Wang, Z., Gu, Q., and Godowski, P. J. (1994) J. Biol. Chem. 269, 15092-15100
58. Ing, Y. L., Leung, W. L., Heng, H. H. Q., Tsui, L. C., and Lassam, N. J. (1994) Oncogene 9, 1745-1750
59. Reddy, U. R., and Pleasure, D. (1994) Biochem. Biophys. Res. Commun. 202, 613-620
60. Katoh, M., Hirai, M., Sugimura, T., and Terada, M. (1995) Oncogene 10, 1447-1451
61. Hirai, S., Izawa, M., Osada, S., Spyrou, G., and Ohno, S. (1996) Oncogene 12, 641-650
62. Young, P. R. McLaughlin, M. M., Kumar, S., Kassis, S., Doyle, M. L., McNulty, D., Gallagher, T. F., Fisher, S., McDonnell, P. C., Carr, S. A., Huddleston, M. J., Seibel, G., Porter, T. G., Livi, G. P., Adams, J. L., and Lee, J. C. (1997) J. Biol. Chem. 272, 12116-12121
63. Tong, L., Pav, S., White, D. M., Rogers, S., Crane, K. M., Cywin, C. L., Brown, M. L., and Pargellis, C. A. (1997) Nat. Struct. Biol. 4, 311-316
64. de Azevedo, W. F., Jr., Mueller-Dieckmann, H.-J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S.-H. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2735-2740
65. Koide, K., Bunnage, M. E., Paloma, L. G., Kanter, J. R., Taylor, S. S., Brunton, L. L., and Nicolaou, K. C. (1995) Chem. Biol. 2, 601-608
66. Hirai, S., Katoh, M., Terada, M., Kyriakis, J. M., Zon, L. I., Rana, A., Avruch, J., and Ohno, S. (1997) J. Biol. Chem. 272, 15167-15173
67. Cuenda, A., and Dorow, D. S. (1998) J. Biochem. 333, 11-15
68. Vacratsis, P. O., and Gallo, K. A. (2000) J. Biol. Chem. 275, 27893-27900
69. Rasmussen, R. K., Rusak, J., Price, G., Robinson, P. J., Simpson, R. J., and Dorow, D. S. (1998) Biochem. J. 335, 119-124
70. Rasmussen, R. K., Ji, H., Eddes, J. S., Moritz, R. L., Reid, G. E., Simpson, R. J., and Dorow, D. S. (1998) Electrophoresis 19, 809-817
71. Lee, F. S., Hagler, J., Chen, Z. J., and Maniatis, T. (1997) Cell 88, 213-222
72. Malinin, N. L., Boldin, M. P., Kovalenko, A. V., and Wallach, D. (1997) Nature 385, 540-544
73. Ling, L., Cao, Z., and Goeddel, D. V. (1997) Proc. Natl. Acad. Sci. U. S. A. 95, 3792-3797
74. Bergeron, P., Douziech, M., Daigle, N., and Blouin, R. (1997) Biochem. Biophys. Res. Commun. 231, 153-155
75. Hartkamp, J., Troppmair, J., and Rapp, U. R. (1999) Cancer Res. 59, 2195-2202