CEP-1347 inhibits caerulein-induced rat pancreatic JNK activation and ameliorates caerulein pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 1 41-1, 2000, Pages

  Wagner, Andreas C C ^a   Mazzucchelli, Luca ^a   Miller, Matthew ^b   Camoratto, Anna Marie ^b   Göke, Burkhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b CEPHALON INC   (United States)

Author keywords

Dually phosphorylated kinases; Pancreatic stress response

Indexed keywords

CEP 1347; CERULETIDE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITOR INTERACTION; HISTOPATHOLOGY; MALE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; RAT;

EID: 0033954869     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.1.g165     Document Type: Article

References (35)

1. Anderson, N. G., J. L. Maller, N. K. Tonks, and T. W. Sturgill. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343: 651-653, 1990.
2. Crews, C. M., and R. L. Erikson. Purification of a murine protein tyrosine/threonine kinase that phosphorylates and activates the Erk1 gene product. Proc. Natl. Acad. Sci. USA 89: 8205-8209, 1992.
3. Dabrowski, A., T. Grady, C. D. Logsdon, and J. A. Williams. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J. Biol. Chem. 271: 5686-5690, 1996.
4. Duan, R.-D., and J. A. Williams. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini. Am. J. Physiol. Gastrointest. Liver Physiol. 267: G401-G408, 1994.
5. Duan, R.-D., C.-F. Zheng, K.-L. Guan, and J. A. Williams. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am. J. Physiol. Gastrointest. Liver Physiol. 268: G1060-G1065, 1995.
6. Gardner, J. D., and R. T. Jensen. Receptors for secretagogues on pancreatic acinar cells. In: The Pancreas, edited by V. L. W. Go, E. Dimagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. New York: Raven, 1993, p. 151-166.
7. Glicksman M. A., A. Y. Chiu, C. A. Dionne, M. Harty, M. Kaneko, C. Murakata, R. W. Oppenheim, D. Prevette, D. R. Sengelaub, J. L. Vaught, and N. T. Neff. CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo. J. Neurobiol. 35: 361-370, 1998.
8. Grady, T., A. Dabrowski, J. A. Williams, and C. D. Logsdon. Stress-activated protein kinase activation is the earliest direct correlate to the induction of secretagogue-induced pancreatitis in rats. Biochem. Biophys. Res. Commun. 227: 1-7, 1996.
9. Grady, T., P. Liang, A. S. Ernst, and C. D. Logsdon. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology 113: 1966-1975, 1997.
10. Grendell, J. H. Acute pancreatitis. Curr. Opin. Gastroenterol. 13: 381-385, 1997.
11. Groblewski, G. E., M. Yoshida, H. Yao, J. A. Williams, and S.A. Ernst. Immunolocalization of CRHSP28 in exocrine digestive glands and gastrointestinal tissues of the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G219-G226, 1999.
12. Han, J., J.-D. Lee, L. Bibbs, and R. J. Ulevitch. AMAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.
13. Huang, W., and R. L. Erikson. Map kinases in multiple signaling pathways. In: Modular Texts in Molecular and Cell Biology. 1. Signal Transduction, edited by C.-H. Heldin and M. Purton. London: Chapman and Hall, 1996, p. 159-172.
14. Kaneko, M., Y. Saito, H. Saito, T. Matsumoto, Y. Matsuda, J. L. Vaught, C. A. Dionne, T. S. Angeles, M. A. Glicksman, N. T. Neff, D. P. Rotella, J. C. Kauer, J. P. Mallamo, R. L. Hudkins, and C. Murakata. Neurotrophic 3,9-bis[(alkylthio) methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J. Med. Chem. 40: 1863-1869, 1997.
15. Kase, H., K. Iwahashi, and Y. Matsuda. K252a, a potent inhibitor of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39: 1059-1065, 1986.
16. Kyriakis, J. M., H. App, and X. Zhang. Raf-1 activates Map kinase kinase. Nature 358: 417-421, 1992.
17. Kyriakis, J. M., P. Banerjee, and E. Nikolakaki. The stress activated protein kinase subfamily of c-jun kinases. Nature 369: 156-160, 1994.
18. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685 1970.
19. Lampel, H., and H. F. Kern. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch. A Pathol. Anat. Histol. 373: 97-117, 1977.
20. Maroney, A. C., M. A. Glicksman, A. N. Basma, K. M. Walton, E. Knight, C. A. Murphy, B. A. Bartlett, J. P. Finn, T. Angeles, Y. Matsuda, N. T. Neff, and C. A. Dionne. Motoneuron apoptosis is blocked by CEP-1347 (KT7515), a novel inhibitor of the JNK signaling pathway. J. Neurosci. 18: 104-111, 1998.
21. Metzler, W., T. Höfken, H. Weber, H. Printz, B. Göke, and A. C. C. Wagner. Hyperthermia, inducing pancreatic HSP's, fails to prevent cerulein-induced stress kinase activation. Pancreas 19: 150-157, 1999.
22. Neoptolemos, J. P., M. Raraty, M. Finch, and R. Sutton. Acute pancreatitis: the substantial human and financial costs. Gut 42: 886-891, 1998.
23. Payne, D. M., A. J. Rossomando, and P. Martino. Identification of the regulatory phosphorylation sites in pp42/mitogen activated protein kinase (MAP kinase). EMBO J. 10: 885-892, 1991.
24. Ray, L. B., and T. W. Sturgill. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc. Natl Acad Sci. USA 84: 1502-1506, 1987.
25. Rouse, J., P. Cohen, S. Trigon, M. Morange, A. AlonsoLlamazares, D. Zamanillo, T. Hunt, and A. R. Nebrada. A novel kinase cascade triggered by stress and heat shock that stimulates mapkap kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037, 1994.
26. Saluja, A. K., M. Saluja, H. Printz, A. Zavertnik, A. Sengupta, and M. L. Steer. Experimental pancreatitis is mediated by low-affinity cholecystokinin receptors that inhibit digestive enzyme release. Proc. Natl. Acad. Sci. USA 86: 8968-8971, 1989.
27. Sanchez, I., R. T. Hughes, and B. J. Mayer. Role of SAPK/ ERK kinase-1 in the stress activated pathway regulating transcription factor c-jun. Nature 372: 794-798, 1994.
28. Schäfer, C., S. E. Ross, M. J. Bragado, G. E. Groblewski, S. A. Ernst, and J. A. Williams. A role for the p38 mitogen-activated protein kinase/HSP27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini. J. Biol. Chem. 273: 24173-24180, 1998.
29. Steer, M. L. The early intraacinar cell events which occur during acute pancreatitis. Pancreas 17: 31-37, 1998.
30. Strowski, M. Z., G. Sparmann, H. Weber, F. Fiedler, H. Printz, L. Jonas, B. Göke, and A. C. C. Wagner. Induction of cerulein pancreatitis increases mRNA but reduces protein levels of pancreatic heat shock proteins in rat. Am. J. Physiol. Gastrointest. Liver Physiol. 273: G937-G945, 1997.
31. Wagner, A. C. C., M. Metzler, H. Weber, T. Höfken, and B. Göke. p38 Map kinase is expressed in the pancreas and is immediately activated following cerulein hyperstimulation. Digestion 60: 41-47, 1999.
32. Wagner, A. C. C., H. Weber, L. Jonas, H. Nizze, M. Strowski, F. Fiedler, H. Printz, H. Steffen, and B. Göke. Hyperthermia induces heat shock protein expression and protection against cerulein pancreatitis in rats. Gastroenterology 111: 1133-1142, 1996.
33. Wagner, A. C. C., M. J. Wishart, S. M. Mulders, P. M. Blevins, P. C. Andrews, and J. A. Williams. GP-3: a newly characterized protein on the inner surface of the zymogen granule membrane undergoes regulated secretion. J. Biol. Chem. 269: 9099-9104, 1994.
34. Wagner, A. C. C., M. J. Wishart, D. I. Yule, and J. A. Williams. Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling. Am. J. Physiol. Cell Physiol. 263: C1172-C1189, 1992.
35. Wan, Y., T. Kurosaki, and X.-Y. Huang. Tyrosine kinases in activation of the MAP kinase cascade by G-protein coupled receptors. Nature 380: 541-544, 1996.