POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis

EMBO Journal

Volumn 22, Issue 2, 2003, Pages 252-261

  Xu, Zhiheng ^a   Kukekov, Nickolay V ^a   Greene, Lloyd A ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Apoptosis; JNKs; MLKs; POSH; Protein scaffold

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GUANOSINE TRIPHOSPHATE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MIXED LINEAGE KINASE; MIXED LINEAGE LEUKEMIA PROTEIN; NERVE GROWTH FACTOR; PROTEASOME; PROTEIN; PROTEIN CDC42; PROTEIN POSH; PROTEIN SH3; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SYMPATHETIC NERVE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CYSTEINE ENDOPEPTIDASES; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROMOLECULAR SUBSTANCES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; MULTIPROTEIN COMPLEXES; NERVE GROWTH FACTOR; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RAC1 GTP-BINDING PROTEIN; RATS; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SYMPATHETIC NERVOUS SYSTEM; ZINC FINGERS;

JANUS;

EID: 0037439170     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg021     Document Type: Article

References (33)

1. Angelastro, J.M., Ho, C.L., Frappier, T., Liem, R.K. and Greene, L.A. (1998) Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine. J. Neurochem., 70, 540-549.
2. Bazenet, C.E., Mota, M.A. and Rubin, L.L. (1998) The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc. Natl Acad. Sci. USA, 95, 3984-3989.
3. Bock, B.C., Vacratsis, P.O., Qamirani, E. and Gallo, K.A. (2000) Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation. J. Biol. Chem., 275, 14231-14241.
4. Bruckner, S.R., Tammariello, S.P., Kuan, C.Y., Flavell, R.A., Rakic, P. and Estus, S. (2001) JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. J. Neurochem. 78, 298-303.
5. Chuang, T.H., Hahn, K.M., Lee, J.D., Danley, D.E. and Bokoch, G.M. (1997) The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol. Biol. Cell, 8, 1687-1698.
6. Chung, K.K., Dawson, V.L. and Dawson, T.M. (2001) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci., 24, S7-S14.
7. Deshmukh, M., Vasilakos, J., Deckwerth, T.L., Lampe, P.A., Shivers, B.D. and Johnson, E.M., Jr (1996) Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J. Cell Biol., 135, 1341-1354.
8. Eilers, A., Whitfield, J., Babij, C., Rubin, L.L. and Ham, J. (1998) Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J. Neurosci., 18, 1713-1724.
9. Ham, J., Eilers, A., Whitfield, J., Neame, S.J. and Shah, B. (2000) c-Jun and the transcriptional control of neuronal apoptosis. Biochem. Pharmacol., 60, 1015-1102.
10. Hu, G. and Fearon, E.R. (1999) Siah-1 N-terminal RING domain is required for proteolysis function and C-terminal sequences regulate oligomerization and binding to target proteins. Mol. Cell. Biol., 19, 724-732.
11. Leung, I.W. and Lassam, N. (1998) Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J. Biol. Chem., 273, 32408-32415.
12. Maroney, A.C. et al. (1999) CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J. Neurochem., 73, 1901-1912.
13. Maroney, A.C. et al. (2001) Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J. Biol. Chem., 276, 25302-25308.
14. Masaki, R., Saito, T., Yamada, K. and Ohtani-Kaneko, R. (2000) Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors. J. Neurosci. Res., 62, 75-83.
15. McDonald, P.H., Chow, C.W., Miller, W.E., Laporte, S.A., Field, M.E., Lin, F.T., Davis, R.J. and Lefkowitz, R.J. (2000) β-Arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science, 290, 1574-1577.
16. Mota, M., Reeder, M., Chernoff, J. and Bazenet, C.E. (2001) Evidence for a role of mixed lineage kinases in neuronal apoptosis. J. Neurosci., 21, 4949-4957.
17. Nihalani, D., Merritt, S. and Holzman, L.B. (2000) Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation. J. Biol. Chem., 275, 7273-7279.
18. Patterson, C. (2002) A new gun in town: the U box is a ubiquitin ligase domain. Sci. STKE, 2002, PE4.
19. Ridley, A.J. (2001) Cyclin' round the cell with Rac. Dev. Cell, 1, 160-161.
20. Saporito, M.S., Thomas, B.A. and Scott, R.W. (2000) MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J. Neurochem., 75, 1200-1208.
21. Tanaka, S. and Hanafusa, H. (1998) Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. J. Biol. Chem., 273, 1281-1284.
22. Tapon, N. and Hall, A. (1997) Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol., 9, 86-92.
23. Tapon, N., Nagata, K., Lamarche, N. and Hall, A. (1998) A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-ΚB signalling pathways. EMBO J., 17, 1395-1404.
24. Teramoto, H., Coso, O.A., Miyata, H., Igishi, T., Miki, T. and Gutkind, J.S. (1996) Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem., 271, 27225-27228.
25. Tournier, C. et al. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science, 288, 870-874.
26. Trotter, L. et al. (2002) Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci. Lett., 320, 29-32.
27. Troy, C.M., Rabacchi, S.A., Xu, Z., Maroney, A.C., Connors, T.J., Shelanski, M.L. and Greene, L.A. (2001a) β Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J. Neurochem., 77, 157-164.
28. Troy, C.M., Rabacchi, S.A., Hohl, J.B., Angelastro, J.M., Greene, L.A. and Shelanski, M.L. (2001b) Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J. Neurosci., 21, 5007-5016.
29. Whitmarsh, A.J. et al. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev., 15, 2421-2432.
30. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. and Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 270, 1326-1331.
31. Xu, Z., Maroney, A.C., Dobrzanski, P., Kukekov, N.V. and Greene, L.A. (2001) The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol. Cell. Biol., 21, 4713-4724.
32. Yang, D.D., Kuan, C.Y., Whitmarsh, A.J., Rincon, M., Zheng, T.S., Davis, R.J., Rakic, P. and Flavell, R.A. (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature, 389, 865-870.
33. Yasuda, J., Whitmarsh, A.J., Cavanagh, J., Sharma, M. and Davis, R.J. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol., 19, 7245-7254.