Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach

Biochemical Pharmacology

Volumn 65, Issue 5, 2003, Pages 857-875

  Heijne, Wilbert H M ^a   Stierum, Rob H ^a   Slijper, Monique ^b   Van Bladeren, Peter J ^c   Van Ommen, Ben ^a  

^a TNO   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Bromobenzene; cDNA microarray; Hepatotoxicity; Proteomics; Toxicogenomics; Transcriptomics

Indexed keywords

ALPHA GLUTAMYLCYSTEINE SYNTHETASE; BROMOBENZENE; CATHEPSIN L; ENZYME; EPOXIDE HYDROLASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE; MESSENGER RNA; PEROXIREDOXIN; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; ENZYME SUBUNIT; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE INDUCTION; GENOMICS; GLUTATHIONE METABOLISM; LIVER TOXICITY; LYSOSOME; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEOMICS; RAT; RNA ANALYSIS; TISSUE LEVEL; UNINDEXED SEQUENCE; WEIGHT REDUCTION;

EID: 0037333902     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01613-1     Document Type: Article

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