RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays

Hepatology

Volumn 33, Issue 5, 2001, Pages 1239-1258

  Bulera, Steven J ^a   Eddy, Susan M ^a   Ferguson, Erika ^b   Jatkoe, Timothy A ^b   Reindel, James F ^a   Bleavins, Michael R ^a   De La Iglesia, Felix A ^c  

^a Drug Safety Evaluation   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CARBON TETRACHLORIDE; COMPLEMENTARY RNA; CYANOGINOSIN LR; CYPROTERONE ACETATE; LIPOPOLYSACCHARIDE; LIVER ENZYME; MESSENGER RNA; PHENOBARBITAL; RNA; THIOACETAMIDE; TOXIC SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENOME; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RAT STRAIN; RNA HYBRIDIZATION; UNINDEXED SEQUENCE;

EID: 0035038751     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.23560     Document Type: Article

References (67)

1. Quantitative monitoring of gene expression patterns with a complimentary DNA microarray
2. Parallel human genome analysis: Microarray-based expression monitoring of 100 genes
3. Microarrays: Biotechnology's discovery platform for functional genomics
4. Expression monitoring by hybridization to high-density oligonucleotide arrays
5. A DNA microarray system for analyzing complex DNA samples using two-color fluorescence probe hybridization
6. Use of cDNA microarray to analyze gene expression patterns in human cancer
7. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
8. Histopathology and molecular biology of ovarian epithelial tumors
9. Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays
10. Concise review: Gene expression applied to toxicology
11. Timely toxicology
12. Microarrays and toxicology: The advent of toxicogenomics
13. The principles and practice of toxicogenomics: Applications and opportunities
14. Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
15. Role of microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide
16. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR
17. Apoptosis, cell proliferation and c-ras expression during and after cyproterone acetate (CPA) induced liver hyperplasia
18. An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
19. 4 hepatotoxicity: A novel dose-response
20. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic reagents?
21. Single step method of RNA isolation by acid guanididium thiocyanate-phenol-chloroform extraction
22. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
23. V clustering gene expression patterns
24. Systematic variation in gene expression patterns in human cancer cell lines
25. Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide
26. Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. I. Induction of drug-metabolizing enzymes
27. Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia
28. A global geometric framework for nonlinear dimensionality reduction
29. Nonlinear dimensionality reduction by locally linear embedding
30. Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats
31. Analysis of the mammalian gadd45 gene and its response to DNA damage
32. Mutagenicity of microcystin-LR in human RSa cells
33. Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437
34. Regulation of the major detoxification functions by phenobarbital and 3-methylcholanthrene in co-cultures of rat hepatocytes and liver epithelial cells
35. Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats
36. Inactivation of glutamine synthetase by a purified rabbit liver microsomal cytochrome P450 system
37. Extent and character of phenobarbital-mediated changes in gene expression in the liver
38. Endocrine factors modulate the phenobarbital-mediated induction of cytochrome P450 and phase II enzymes in a similar strain-dependent manner
39. Aryl hydrocarbon receptor-associated genes in rat liver: Regional coinduction of aldehyde dehydrogenase 3 and glutathione Ya
40. Zoxazolamine-induced paralysis in two rat substrains: Differences in hepatic drug metabolism
41. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures
42. Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry
43. Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide-binding protein via CD14
44. Activation of hepatic proliferation-associated transcription factors by lipopolysaccharide
45. Induction of lipopolysaccharide-binding protein gene expression in cultured rat pulmonary artery smooth muscle by interleukin 1 beta
46. Mechanisms of hypertransaminemia
47. Plasma glutathione S-transferase in carbon tetrachloride treated rats and its association to hepatic cytosolic isozymes
48. Time courses of hepatic injuries induced by chloroform and carbon tetrachloride: Comparison of biochemical and histopathological changes
49. Mechanisms of early carbon tetrachloride toxicity in cultured rat hepatocytes
50. Expression of tumor necrosis factor alpha and transforming from factor-beta 1 in acute liver injury
51. Induction of tumor necrosis factor alpha in experimental animals treated with hepatotoxicants
52. Early ultrastructural changes during thioacetamide-induced apoptosis in rat liver
53. Potentiation of thio-acetamide liver injury in diabetic rats is due to induced CYP2E1
54. Focal nuclear hepatocyte response to oxidative damage following low dose thioacetamide intoxication
55. Nicotine metabolism in liver microsomes from rats with acute hepatitis or cirrhosis
56. The expression of heme oxygenase-1 gene responded to oxidative stress produced by phorone, a glutathione depletor, in the rat liver, the relevance to activation of c-jun terminal kinase
57. Alterations in hepatic peroxidation mechanisms in thioacetamide-induced tumors in rats. Effect of a rhodium (III) complex
58. Heat shock protein 70 in rat liver with necrosis and regeneration induced by thioacetamide
59. The mechanism of thioacetamide-induced apoptosis in the L37 albumin-SV40 T-antigen transgenic rat hepatocyte-derived cell line occurs without DNA fragmentation
60. Effects of testosterone and cyproterone acetate on carbohydrate metabolism in rat mammary glands
61. Effects of hypolipidemic drugs nafenopin and clo-fibrate on phenotypic expression and cell death (apoptosis) in altered hepatic foci of rat liver
62. Steroidal drug cyproterone acetate is activated to DNA-binding metabolites by sulfonation