CD4+CD25high regulatory T cells are markedly decreased in blood of patients with pemphigus vulgaris

Dermatology

Volumn 214, Issue 3, 2007, Pages 210-220

  Sugiyama, H ^a   Matsue, H ^a   Nagasaka, A ^a   Nakamura, Y ^a   Tsukamoto, K ^b   Shibagaki, N ^a   Kawamura, T ^a   Kitamura, R ^a   Ando, N ^a   Shimada, S ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Yamanashi Prefectural Central Hospital   (Japan)

Author keywords

Autoimmune disease; Pemphigus vulgaris; Regulatory T cells; Self tolerance

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD PRESSURE REGULATION; CD4+ CD25+ T LYMPHOCYTE; CELL POPULATION; EVALUATION; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; PEMPHIGUS VULGARIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL SEPARATION; CYTOLOGY; IMMUNOLOGY; MIDDLE AGED; PEMPHIGUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; PEMPHIGUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY;

EID: 33947393629     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099585     Document Type: Article

References (52)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-562.
2. O'Garra A, Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med 2004;10:801-805.
3. Mills KH: Regulatory T cells: Friend or foe in immunity to infection? Nat Rev Immunol 2004;4:841-855.
4. + suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389-400.
5. Maloy KJ, Powrie F: Regulatory T cells in the control of immune pathology. Nat Immunol 2001;2:816-822.
6. Vigouroux S, Yvon E, Biagi E, Brenner MK: Antigen-induced regulatory T cells. Blood 2004;104:26-33.
7. Asano M, Toda M, Sakaguchi N, Sakaguchi S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-396.
8. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998;10:1969-1980.
9. high regulatory cells in human peripheral blood. J Immunol 2001;167:1245-1253.
10. Baecher-Allan C, Hafler DA: Suppressor T cells in human diseases. J Exp Med 2004;200:273-276.
11. high regulatory T cells in psoriasis: Mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005;174:164-173.
12. + regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199:971-979.
13. + regulatory T Cells in autoimmune polyglandular syndrome type II. J Exp Med 2004;199:1285-1291.
14. Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004;200:277-285.
15. + T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005;105:735-741.
16. + T-cells from patients with type 1 diabetes. Diabetes 2005;54:92-99.
17. Payne AS, Hanakawa Y, Amagai M, Stanley JR: Desmosomes and disease: pemphigus and bullous impetigo. Curr Opin Cell Biol 2004;16:536-543.
18. Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T: Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 2000;105:625-631.
19. Anhalt GJ, Diaz LA: In vivo studies of antibody dependent acantholysis. Immunol Ser 1989;46:291-316.
20. Veldman C, Stauber A, Wassmuth R, Uter W, Schuler G, Hertl M: Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles. J Immunol 2003;170:635-642.
21. Karagiannidis C, Akdis M, Holopainen P, Woolley NJ, Hense G, Ruckert B, Mantel PY, Menz G, Akdis CA, Blaser K, Schmidt-Weber CB: Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004;114:1425-1433.
22. Morse DL, Carroll D, Weberg L, Borgstrom MC, Ranger-Moore J, Gillies RJ: Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem 2005;342:69-77.
23. high regulatory T cells increases with age. Clin Exp Immunol 2005;140:540-546.
24. high regulatory T cells are not impaired in patients with primary Sjogren's syndrome. J Autoimmun 2005;24:235-242.
25. high regulatory T cells. Blood 2004;103:2410-2416.
26. Crispin JC, Martinez A, Alcocer-Varela J: Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003;21:273-276.
27. + T cells with regulatory properties from human blood. J Exp Med 2001;193:1303-1310.
28. + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001;31:1247-1254.
29. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-1302.
30. + regulatory T cells. J Exp Med 2001;194:847-853.
31. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061.
32. + T regulatory cells. Nat Immunol 2003;4:337-342.
33. + regulatory T cells. Nat Immunol 2003;4:330-336.
34. Sakaguchi S, Sakaguchi N: Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J Immunol 1989;142:471-480.
35. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 2002;168:5979-5983.
36. + regulatory T cells. J Immunol 2003;170:3939-3943.
37. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12:431-440.
38. + T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004;59:198-202.
39. + regulatory T-cells in autoimmune liver disease. J Hepatol 2004;41:31-37.
40. - T cells to dexamethasone-induced cell death. Eur J Immunol 2004;34:859-869.
41. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L: Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 2001;167:1945-1953.
42. + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-2868.
43. + T regulatory cell activities in lung cancer. Cancer Res 2005;65:5211-5220.
44. Kawai M, Kitade H, Mathieu C, Waer M, Pirenne J: Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo. Transplantation 2005;79:1073-1077.
45. + regulatory T cells. Nat Med 2005;11:1238-1243.
46. Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM: JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000;106:R75-R81.
47. Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001;27:18-20.
48. Patten SF, Dijkstra JW: Associations of pemphigus and autoimmune disease with malignancy or thymoma. Int J Dermatol 1994;33:836-842.
49. Veldman C, Hohne A, Dieckmann D, Schuler G, Hertl M: Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris. J Immunol 2004;172:6468-6475.
50. + T helper cells. J Exp Med 2002;196:255-260.
51. + T cells in the control of inflammation. J Immunol 2003;171:5018-5026.
52. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med 2002;196:247-253.