Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death

European Journal of Immunology

Volumn 34, Issue 3, 2004, Pages 859-869

  Chen, Xin ^a   Murakami, Takaya ^b   Oppenheim, Joost J ^b   Howard, O M Zack ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CD4+CD25+; Cell death; Dexamethasone; T cell

Indexed keywords

CD4 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; INTERLEUKIN 10; LEUKOCYTE ANTIGEN; NERVE GROWTH FACTOR RECEPTOR; TNFRSF18 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS; ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; SPLEEN; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GLUCOCORTICOID; RECEPTORS, INTERLEUKIN-2; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SPLEEN; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 1642308173     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324506     Document Type: Article

References (42)

1. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389-400.
2. + T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 1997. 389: 737-742.
3. Cottrez, F., Hurst, S. D., Coffman, R. L. and Groux, H., T regulatory cells 1 inhibit a Th2-specific response in vivo. J. Immunol. 2000. 165: 4848-4853.
4. Levings, M. K., Sangregorio, R., Galbiati, F., Squadrone, S., de Waal Malefyt, R. and Roncarolo, M. G., IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J. Immunol. 2001. 166: 5530-5539.
5. + regulatory T cells from human poripheral blood. J. Immunol. 2001. 166: 7282-7289.
6. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002. 99: 3493-3499.
7. Gregori, S., Casorati, M., Amuchastegui, S., Smiroldo, S., Davalli, A. M. and Adorini, L., Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 2001. 167: 1945-1953.
8. Gregori, S., Giarratana, N., Smiroldo, S., Uskokovic, M. and Adorini, L., A 1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cdells and arrests autoimmune diabetes in NOD mice. Diabetes 2002. 51: 1367-1374.
9. + subset of recent thymic emigrants. J. Immunol. 2001. 166: 7158-7164.
10. + T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 2001. 31: 1122-1131.
11. Papiernik, M., do Carmo Leite-de-Moraes, M., Pontoux, C., Joret, A. M., Rocha, B., Penit, C. and Dy, M., T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity. J. Immunol. 1997. 158: 4642-4653.
12. Banz, A., Pontoux, C. and Papiernik, M., Modulation of fasdependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells. J. Immunol. 2002. 169: 750-757.
13. Almawi, W. Y., Beyhum, H. N., Rahme, A. A. and Rieder, M. J., Regulation of cytokine and cytokine receptor expression by glucocorticoids. J. Leukoc. Biol. 1996. 60: 563-572.
14. Planey, S. L. and Litwack, G., Glucocorticoid-induced apoptosis in lymphocytes. Biochem. Biophys. Res. Commun. 2000. 279: 307-312.
15. Zelenika, D., Adams, E., Humm, S., Graca, L., Thompson, S., Cobbold, S. P. and Waldmann, H., Regulatory T cells overexpress a subset of Th2 gene transcripts. J. Immunol. 2002. 168: 1069-1079.
16. Ashwell, J. D., Lu, F. W. and Vacchio, M. S., Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 2000. 18: 309-345.
17. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 2002. 195: 603-616.
18. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002. 16: 311-323.
19. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 2002. 3: 135-142.
20. Tarcic, N., Ovadia, H., Weiss, D. W. and Weidenfeld, J., Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids. J. Neuroimmunol. 1998. 82: 40-46.
21. low thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. Eur. J. Immunol. 2001. 31: 2293-2301.
22. Han, S., Choi, H., Ko, M. G., Choi, Y. I., Sohn, D. H., Kim, J. K., Shin, D., Chung, H., Lee, H. W., Kim, J. B., Park, S. D. and Seong, R. H., Peripheral T cells become sensitive to glucocorticoid- and stress- induced apoptosis in transgenic mice overexpressing SRG3. J. Immunol. 2001. 167: 805-810.
23. Huang, S. T. and Cidlowski, J. A., Phosphorylation status modulates Bcl-2 function during glucocorticoid- induced apoptosis in T lymphocytes. FASEB J. 2002. 16: 825-832.
24. Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., Fields, L. E., Lucas, P. J., Stewart, V., Alt, F. W. et al., Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 1993. 261: 1584-1588.
25. Riccardi, C., Cifone, M. G. and Migliorati, G., Glucocorticoid hormone-induced modulation of gene expression and regulation of T cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ. 1999. 6: 1182-1189.
26. + glucocorticoid-incluced TNF receptor family-related gene+ regulatory T cells. J Immunol 2003. 171: 708-716.
27. Egen, J. G., Kuhns, M. S. and Allison, J. P., CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat. Immunol. 2002. 3: 611-618.
28. + regulatory T cells prevent graft rejection: CTLA-4-and IL-10- dependent immunoregulation of alloresponses. J. Immunol. 2002. 168: 1080-1086.
29. Xia, M., Gasser, J. and Feige, U., Dexamethasone enhances CTLA-4 expression during T cell activation. Cell Mol. Life Sci. 1999. 55: 1649-1656.
30. Agarwal, S. K. and Marshall, G. D., Jr., Role of CD28/B7 costimulation in the dexamethasone-induced suppression of IFN-gamma. J. Interferon Cytokine Res. 2000. 20: 927-934.
31. Sade, H. and Sarin, A., IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells. Eur. J. Immunol. 2003. 33: 913-919.
32. Franchimont, D., Galon, J., Vacchio, M. S., Fan, S., Visconti, R., Frucht, D. M., Geenen, V., Chrousos, G. P., Ashwell, J. D. and O'Shea, J. J., Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha. J. Immunol. 2002. 168: 2212-2218.
33. Zubiaga, A. M., Munoz, E. and Huber, B. T., IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid- induced apoptosis. J. Immunol. 1992. 149: 107-112.
34. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993. 75: 253-261.
35. Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. and Alt, F. W., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521-530.
36. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J., Ohashi, P. S., Griesser, H. et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995. 268: 1472-1476.
37. Refaeli, Y., Van Parijs, L., London, C. A., Tschopp, J. and Abbas, A. K., Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998. 8: 615-623.
38. + T cells: evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 2001. 31: 1637-1645.
39. + T cell numbers. J. Immunol. 2002. 169: 4850-4860.
40. + regulatory T cells by oral antigen administration. J. Immunol. 2001. 167: 4245-4253.
41. Telford, W. G., King, L. E. and Fraker, P. J., Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. J. Immunol. Methods 1994. 172: 1-16.
42. + T cells facilitate the induction of T cell anergy. J. Immunol. 2001. 167: 4271-4275.