A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of β-cell dysfunction in the obese diabetic db/db mouse

Diabetes

Volumn 45, Issue 5, 1996, Pages 580-586

  Zhou, Yun Ping ^a   Berggren, Per Olof ^a   Grill, Valdemar ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; ETOMOXIR; FATTY ACID; GLUCOSE; INSULIN; PALMITIC ACID; PYRUVATE DEHYDROGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEMALE; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0029983884     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.45.5.580     Document Type: Article

References (35)

1. Leahy JL, Bonner-Weir S, Weir GC: β-Cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15:442-455, 1992
2. Kaiser N, Corcos AP, Sarel I, Cerasi E Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of β-cell function by chronic exposure to high glucose. Endocrinology 129:2067-2076, 1991
3. Robertson RP, Olson LK, Zhang HJ. Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene Diabetes 43:1085-1089, 1994
4. Sako Y, Grill V: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
5. Zhou YP, Grill V: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
6. Zhou YP, Grill V: Long-term exposure to fatty acids and ketones inhibits β-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1575-1560, 1995
7. Capito K, Hansen SE, Hedeskov CJ, Thams P: Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism. Acta Diabetol 28:193-198, 1992
8. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci USA 91:10878-10882, 1994
9. Zhou YP, Grill V: Palmitate-induced β-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44:394-399, 1995
10. Tuman RW, Doisy RJ: The influence of age on development of hypertriglyceridaemia and hypercholesterolaemia in genetically diabetic mice. Diabetologia 13:7-11, 1977
11. Memon RA, Grunfeld C, Moser AH, Feingold KR: Fatty acid synthesis in obese insulin resistant diabetic mice. Horm Metab Res 26:85-87, 1994
12. Reaven GM: The fourth musketeer: from Alexandre Dumas to Claude Bernard. Diabetologia 38:3-13, 1995
13. Berglund O, Frankel BJ, Hellman B. Development of the insulin secretion defect in genetically diabetic (db/db) mouse. Acta Endocrinol 87:543-551, 1978
14. Thorens B, Wu YJ, Leahy JL, Weir GC: The loss of GLUT2 expression by glucose-unresponsive β cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Invest 90:77-85, 1992
15. Liang Y, Bonner-Weir S, Wu Y-J, Berdanier CD, Berner DK, Efrat S, Matschinsky FM: In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. J Clin Invest 93:2473-2481, 1994
16. Sener A, Herberg L, Malaisse WJ: FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes. FEBS Lett 316:224-227, 1993
17. 2+ sequestration in diabetic mouse islets of Langerhans. J Biol Chem 269:18279-18282, 1994
18. Wolf HPO: Aryl-substituted 2-oxirane carboxylic acids: a new group of antidiabetic drugs. In New Antidiabetic Drugs. Bailey CJ, Flatt PR, Eds. London, Smith-Gordon, 1990, p. 217-229
19. Lacy PE, Kostianovsky M: Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967
20. Keen H, Field JB, Pastan IH. A simple method for in vitro metabolic studies using small volumes of tissue and medium. Metab Clin Exp 12:143-147, 1963
21. Ashcroft SJH, Weerasinghe LCC, Bassett JM, Randle PJ: The pentose cycle and insulin release in mouse pancreatic islets. Biochem J 126:525-532, 1972
22. Paxton R, Harris RA, Sener A, Malaisse WJ: Branched chain α-ketoacid dehydrogenase and pyruvate dehydrogenase in isolated rat pancreatic islets. Horm Metab Res 20:317-322, 1988
23. MacDonald MJ, McKenzie DI, Kaysen JH, Walker TM, Moran SM, Fahien LA, Towle HC: Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E 1α subunit gene in pancreatic islets. J Biol Chem 266:1335-1340, 1991
24. Seversen DL, Denton RM, Pask HT, Randle PJ: Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphalase. Biochem J 140:225-237, 1974
25. Kaempfer S, Blankham M, Christiansen M, Wu K, Cesar D, Vary T, Hellerstein MK: Fraction of hepatic cytosolic acetyl-CoA derived from glucose in vivo, relation to PDH phosphorylation state Am J Physiol 260.E865-E875, 1991
26. Kerbey AL, Randle PJ: Pyruvate dehydrogenase kinase/activator in rat heart mitochondria: assay, effect of starvation, and effect of protein-synthesis inhibitors in starvation. Biochem J 200:103-111, 1982
27. Denyer GS, Kerbey AL, Randle PJ: Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria. Biochem J 239:347-354, 1986
28. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin J Clin Endocrinol Metab 25.1375-1385, 1965
29. , Hinegardner RT: An improved fluorometric assay for DNA. Anal Biochem 39:197-201, 1971
30. Randle PJ, Priestman DA, Mistry SC, Halsall A: Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 55S:1-11, 1994
31. Declercq PE, Falck JR, Kuwajima M, Tyminski H, Foster DW, McGarry JD: Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system I: use of inhibitors. J Biol Chem 262:9812-9821, 1987
32. McCormack JG, Longo EA, Corkey BE. Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem J 267:527-530, 1990
33. Milburn JL Jr, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, Rio HB, Newgard CB, Johnson JH, Unger RH: Pancreatic β-cells in obesity, evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids J Biol Chem 270:1295-1299, 1995
34. Grill VE, Sako Y, Bjorklund A, Inoue K: Mechanisms underlying the influence of a diabetic state on pancreatic β-cell function. In Frontiers of Insulin Secretion and Pancreatic β-cell Research Flatt PR, Lenzen S, Eds. London, Smith-Gordon, 1994, p 473-479
35. Polonsky KS: The β-cell in diabetes: from molecular genetics to clinical research. Diabetes 44:705-717