Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

Journal of Lipid Research

Volumn 48, Issue 2, 2007, Pages 318-327

  Lee, Peter C W ^a   Nguyen, Andrew D ^a   DeBose Boyd, Russell A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase; Cholesterol homeostasis; Endoplasmic reticulum associated degradation; Membrane attachment region; Mutagenesis; Somatic cell genetics; Ubiquitination

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CARRIER PROTEIN; GLYCINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PROLINE; PROTEASOME; PROTEIN INSIG; SERINE; SR 12813; STEROL; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ISOLATION; CELL SELECTION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; MEMBRANE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SUBSTITUTION REACTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STEROLS; UBIQUITINATION;

EID: 33846882148     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600476-JLR200     Document Type: Article

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