Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 24, 1996, Pages 13709-13714

  Nohturfft, Axel ^a   Hua, Xianxin ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol; Low density receptors; Somatic cell mutations; Sterol regulatory element binding protein

Indexed keywords

25 HYDROXYCHOLESTEROL; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; CELL MUTANT; CHO CELL; CHOLESTEROL SYNTHESIS; CODON; CONFERENCE PAPER; DNA SEQUENCE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC CELL GENETICS; TRANSCRIPTION REGULATION;

ADENINE; ANIMALS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CHO CELLS; CHOLESTEROL; CLONE CELLS; CODON; CRICETINAE; DNA PRIMERS; DNA-BINDING PROTEINS; DRUG RESISTANCE; GUANINE; HAPLOTYPES; HELIX-LOOP-HELIX MOTIFS; HYDROXYCHOLESTEROLS; NUCLEAR PROTEINS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030472004     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.24.13709     Document Type: Article

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