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Volumn 26, Issue 2, 2006, Pages 267-271

Endothelial nitric oxide synthase: Host defense enzyme of the endothelium?

Author keywords

Atherosclerosis; Endothelium; Nitric oxide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

EID: 33644857154     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000196554.85799.77     Document Type: Review
Times cited : (81)

References (46)
  • 3
    • 0035929149 scopus 로고    scopus 로고
    • Nitrosylation: The prototypic redox-based signaling mechanism
    • Stamler JS, Lamas S, Fang FC. Nitrosylation: the prototypic redox-based signaling mechanism. Cell. 2001;106:675-683.
    • (2001) Cell , vol.106 , pp. 675-683
    • Stamler, J.S.1    Lamas, S.2    Fang, F.C.3
  • 4
    • 0037365968 scopus 로고    scopus 로고
    • Specificity of a third kind: Reactive oxygen and nitrogen intermediates in cell signaling
    • Nathan C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J Clin Invest. 2003;111:769-778.
    • (2003) J Clin Invest , vol.111 , pp. 769-778
    • Nathan, C.1
  • 7
    • 0036513249 scopus 로고    scopus 로고
    • Opinion - Does nitric oxide modulate mitochondrial energy generation and apoptosis?
    • Moncada S, Erusalimsky JD. Opinion - Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nature Reviews Molecular Cell Biol. 2002;3:214-220.
    • (2002) Nature Reviews Molecular Cell Biol , vol.3 , pp. 214-220
    • Moncada, S.1    Erusalimsky, J.D.2
  • 8
    • 0033975850 scopus 로고    scopus 로고
    • Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
    • Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood. 2000;95:189-197.
    • (2000) Blood , vol.95 , pp. 189-197
    • Kimura, H.1    Weisz, A.2    Kurashima, Y.3    Hashimoto, K.4    Ogura, T.5    D'Acquisto, F.6    Addeo, R.7    Makuuchi, M.8    Esumi, H.9
  • 9
    • 0032053707 scopus 로고    scopus 로고
    • Oxygen radicals and signaling
    • Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol. 1998;10:248-253.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 248-253
    • Finkel, T.1
  • 10
    • 4344566972 scopus 로고    scopus 로고
    • Update on mechanism and catalytic regulation in the NO synthases
    • Stuehr DJ, Santolini J, Wang ZQ, Wei CC, Adak S. Update on mechanism and catalytic regulation in the NO synthases. J Biol Chem. 2004;279:36167-36170.
    • (2004) J Biol Chem , vol.279 , pp. 36167-36170
    • Stuehr, D.J.1    Santolini, J.2    Wang, Z.Q.3    Wei, C.C.4    Adak, S.5
  • 11
    • 0034255470 scopus 로고    scopus 로고
    • Identification of proteins containing cysteine residues that are sensitive to oxidation by hydrogen peroxide at neutral pH
    • Kim JR, Yoon HW, Kwon KS, Lee SR, Rhee SG. Identification of proteins containing cysteine residues that are sensitive to oxidation by hydrogen peroxide at neutral pH. Anal Biochem. 2000;283:214-221.
    • (2000) Anal Biochem , vol.283 , pp. 214-221
    • Kim, J.R.1    Yoon, H.W.2    Kwon, K.S.3    Lee, S.R.4    Rhee, S.G.5
  • 12
    • 2342489869 scopus 로고    scopus 로고
    • NF-kappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins
    • Joshi SG, Francis CW, Silverman DJ, Sahni SK. NF-kappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins. FEMS Microbiol Lett. 2004;234:333-341.
    • (2004) FEMS Microbiol Lett , vol.234 , pp. 333-341
    • Joshi, S.G.1    Francis, C.W.2    Silverman, D.J.3    Sahni, S.K.4
  • 13
    • 0346848801 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and nitric oxide: Mechanistic and pharmacological aspects
    • Werner ER, Gorren AC, Heller R, Werner-Felmayer G, Mayer B. Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects. Exp Biol Med. 2003;228:1291-1302.
    • (2003) Exp Biol Med , vol.228 , pp. 1291-1302
    • Werner, E.R.1    Gorren, A.C.2    Heller, R.3    Werner-Felmayer, G.4    Mayer, B.5
  • 14
    • 5444247065 scopus 로고    scopus 로고
    • Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase
    • Berka V, Yeh HC, Gao D, Kiran F, Tsai AL. Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase. Biochemistry. 2004;43:13137-13148.
    • (2004) Biochemistry , vol.43 , pp. 13137-13148
    • Berka, V.1    Yeh, H.C.2    Gao, D.3    Kiran, F.4    Tsai, A.L.5
  • 15
    • 10044245949 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats
    • Meininger CJ, Cai S, Parker JL, Channon KM, Kelly KA, Becker EJ, Wood MK, Wade LA, Wu G. GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats. FASEB J. 2004;18:1900-1902.
    • (2004) FASEB J , vol.18 , pp. 1900-1902
    • Meininger, C.J.1    Cai, S.2    Parker, J.L.3    Channon, K.M.4    Kelly, K.A.5    Becker, E.J.6    Wood, M.K.7    Wade, L.A.8    Wu, G.9
  • 17
    • 0037428209 scopus 로고    scopus 로고
    • Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity
    • d'Uscio LV, Milstien S, Richardson D, Smith L, Katusic ZS. Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res. 2003;92:88-95.
    • (2003) Circ Res , vol.92 , pp. 88-95
    • D'Uscio, L.V.1    Milstien, S.2    Richardson, D.3    Smith, L.4    Katusic, Z.S.5
  • 18
    • 2342625431 scopus 로고    scopus 로고
    • Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis
    • Jennings BL, Broughton BRS, Donald JA. Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis. J Exp Biol. 2004;207:1295-1303.
    • (2004) J Exp Biol , vol.207 , pp. 1295-1303
    • Jennings, B.L.1    Broughton, B.R.S.2    Donald, J.A.3
  • 19
    • 0035209452 scopus 로고    scopus 로고
    • Nitric oxide: Comparative synthesis and signaling in animal and plant cells
    • Wendehenne D, Pugin A, Klessig DF, Dumer J. Nitric oxide: comparative synthesis and signaling in animal and plant cells. Trends Plant Sci. 2001;6:177-183.
    • (2001) Trends Plant Sci , vol.6 , pp. 177-183
    • Wendehenne, D.1    Pugin, A.2    Klessig, D.F.3    Dumer, J.4
  • 20
    • 10844292763 scopus 로고    scopus 로고
    • Immunosuppressive drugs for kidney transplantation
    • Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004;351:2715-2729.
    • (2004) N Engl J Med , vol.351 , pp. 2715-2729
    • Halloran, P.F.1
  • 23
    • 0031002421 scopus 로고    scopus 로고
    • Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
    • Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc Natl Acad Sci U S A. 1997;94:6954-6958.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6954-6958
    • Xia, Y.1    Zweier, J.L.2
  • 24
    • 15444369648 scopus 로고    scopus 로고
    • Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: A proinflammatory role for eNOS-derived no in vivo
    • Connelly L, Madhani M, Hobbs AJ. Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a proinflammatory role for eNOS-derived no in vivo. J Biol Chem. 2005;280:10040-10046.
    • (2005) J Biol Chem , vol.280 , pp. 10040-10046
    • Connelly, L.1    Madhani, M.2    Hobbs, A.J.3
  • 27
    • 0036479117 scopus 로고    scopus 로고
    • Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha-induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells
    • Fan J, Frey RS, Rahman A, Malik AB. Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha-induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells. J Biol Chem. 2002;277:3404-3411.
    • (2002) J Biol Chem , vol.277 , pp. 3404-3411
    • Fan, J.1    Frey, R.S.2    Rahman, A.3    Malik, A.B.4
  • 28
    • 0034633602 scopus 로고    scopus 로고
    • Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation
    • Rhee SG, Bae YS, Lee SR, Kwon J. Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE. 2000;2000:E1.
    • (2000) Sci STKE , vol.2000
    • Rhee, S.G.1    Bae, Y.S.2    Lee, S.R.3    Kwon, J.4
  • 29
    • 0041589260 scopus 로고    scopus 로고
    • The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen
    • Kirsch M, Korth HG, Stenert V, Sustmann R, de Groot H. The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen. J Biol Chem. 2003;278:24481-24490.
    • (2003) J Biol Chem , vol.278 , pp. 24481-24490
    • Kirsch, M.1    Korth, H.G.2    Stenert, V.3    Sustmann, R.4    De Groot, H.5
  • 30
    • 3543042462 scopus 로고    scopus 로고
    • Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin
    • Berka V, Wu G, Yeh HC, Palmer G, Tsai AL. Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin. J Biol Chem. 2004;279:32243-32251.
    • (2004) J Biol Chem , vol.279 , pp. 32243-32251
    • Berka, V.1    Wu, G.2    Yeh, H.C.3    Palmer, G.4    Tsai, A.L.5
  • 31
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmelhionine-dependent methyltransferases
    • Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Boger SM. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S- adenosylmelhionine-dependent methyltransferases. Circ Res. 2000;87:99-105.
    • (2000) Circ Res , vol.87 , pp. 99-105
    • Boger, R.H.1    Sydow, K.2    Borlak, J.3    Thum, T.4    Lenzen, H.5    Schubert, B.6    Tsikas, D.7    Bode-Boger, S.M.8
  • 32
    • 2942577486 scopus 로고    scopus 로고
    • Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway
    • Vallance P, Leiper J Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004;24:1023-1030.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1023-1030
    • Vallance, P.1    Leiper, J.2
  • 33
    • 14844327786 scopus 로고    scopus 로고
    • Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric oxide synthase: Differences in the effects of monomethyl and dimethyl arginines in the presence and absence of tetrahydrobiopterin
    • Cardounel AJ, Xia Y, Zweier JL. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric oxide synthase: Differences in the effects of monomethyl and dimethyl arginines in the presence and absence of tetrahydrobiopterin. J Biol Chem. 2005;280:7540-7549
    • (2005) J Biol Chem , vol.280 , pp. 7540-7549
    • Cardounel, A.J.1    Xia, Y.2    Zweier, J.L.3
  • 34
    • 11344279659 scopus 로고    scopus 로고
    • C-reactive protein levels and outcomes after statin therapy
    • Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, Pfeffer MA, Braunwald E; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 2005;352:20-28.
    • (2005) N Engl J Med , vol.352 , pp. 20-28
    • Ridker, P.M.1    Cannon, C.P.2    Morrow, D.3    Rifai, N.4    Rose, L.M.5    McCabe, C.H.6    Pfeffer, M.A.7    Braunwald, E.8
  • 35
    • 6344285417 scopus 로고    scopus 로고
    • Endothelial cell superoxide generation: Regulation and relevance for cardiovascular pathophysiology
    • Li JM, Shah AM. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1014-R1030.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Li, J.M.1    Shah, A.M.2
  • 37
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, Channon KM. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 2002;105:1656-1662.
    • (2002) Circulation , vol.105 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 38
    • 0037470807 scopus 로고    scopus 로고
    • NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein
    • Matsunaga T, Hokari S, Koyama I, Harada T, Komoda T. NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein. Biochem Biophys Res Commun. 2003;303:313-319.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 313-319
    • Matsunaga, T.1    Hokari, S.2    Koyama, I.3    Harada, T.4    Komoda, T.5
  • 40
    • 0029121091 scopus 로고
    • Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication
    • Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 1995;346:467-471.
    • (1995) Lancet , vol.346 , pp. 467-471
    • Stroes, E.S.1    Koomans, H.A.2    De Bruin, T.W.3    Rabelink, T.J.4
  • 42
    • 0037231551 scopus 로고    scopus 로고
    • Adverse effects of supplemental L-arginine in atherosclerosis: Consequences of methylation stress in a complex catabolism?
    • Loscalzo J. Adverse effects of supplemental L-arginine in atherosclerosis: consequences of methylation stress in a complex catabolism? Arterioscler Thromb Vasc Biol. 2003;23:3-5.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 3-5
    • Loscalzo, J.1
  • 43
    • 13444262357 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Regulator of endothelial nitric oxide synthase in vascular disease
    • Channon KM. Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc Med. 2004;14:323-327.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 323-327
    • Channon, K.M.1
  • 44
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T, Krohn K, Albers S, Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia. 2000;43:1435-1438.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 46
    • 2542429299 scopus 로고    scopus 로고
    • The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency
    • Blau N, Erlandsen H. The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Mol Genet Metab. 2004;82:101-111.
    • (2004) Mol Genet Metab , vol.82 , pp. 101-111
    • Blau, N.1    Erlandsen, H.2


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