Inducible nitric-oxide synthase generates superoxide from the reductase domain

Journal of Biological Chemistry

Volumn 273, Issue 35, 1998, Pages 22635-22639

  Xia, Yong ^a   Roman, Linda J ^b   Masters, Bettie Sue S ^b   Zweier, Jay L ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ARGININE; CITRULLINE; CYANIDE; DEXTRO ARGININE; DIPHENYLIODONIUM SALT; HEME; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; OXYGEN; OXYGENASE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SYNTHESIS;

ANIMALS; CATALYSIS; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDOREDUCTASES; OXYGENASES; RECOMBINANT PROTEINS; SPIN LABELS; SUPEROXIDES;

EID: 0032575598     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.35.22635     Document Type: Article

References (29)

1. Moncada, S., Palmer, R. M., and Higgs, E. A. (1991) Pharmacol. Rev. 43, 109-142
2. Marletta, M. A. (1993) J. Biol. Chem 268, 12231-12234
3. Masters, B. S. S., McMillan, K., Sheta, E. A., Nishimura, J. S., Roman, L. J., and Martasek, P. (1996) FASEB J. 10, 552-558
4. Nathan, C., and Xie, Q.-w. (1994) Cell. 78, 915-918
5. Griffith, O. W., and Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736
6. Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., and Rosen, G. M. (1992) J. Biol. Chem. 267, 24173-24176
7. Heinzel, B., John, M., Klatt, P., Bohme, E., and Mayer, B. (1992) Biochem. J. 281, 627-630
8. Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., and Zweier, J. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6770-6774
9. Abu-Soud, H. M., and Stuehr D. J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10769-10772
10. Bastian N. R., and Hibbs, J. B., Jr. (1994) Curr. Opin. Immunol. 6, 131-139
11. Xia, Y., and Zweier, J. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6954-6958
12. Frejaville, C., Karoui, H., Tucci, B., Le Moigne, F., Culcasi, M., Pietri, S., Lauricella, R., and Tordo, P. (1995) J. Med. Chem. 38, 258-262
13. Roman, L. J., Sheta, E. A., Martasek, P., Gross, S. S., Liu, Q., and Masters, B. S. S. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8428-8432
14. Fosseta, J. D., Niu, X. D., Lunn, C. A., Zavodny, P. J., Narula, S. K., and Lundell, D. (1996) FEBS Lett. 379, 135-138
15. Bredt, D. S., and Snyder, S. H. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 9030-9033
16. Giraldez, R. R., Panda, A., Xia, Y., Sanders, S. P., and Zweier, J. L. (1997) J. Biol. Chem. 272, 21420-21426
17. Xia, Y., Khatchikian, G., and Zweier, J. L. (1996) J. Biol. Chem. 271, 10096-10102
18. Gerber, N. C., and Ortiz de Montellano, P. (1995) J. Biol. Chem. 270, 17791-17796
19. Martasek, P., Liu, Q., Liu, J., Roman, L. J., Sheta, E. A., Gross, S. S., Sessa, W. C., and Masters, B. S. S. (1996) Biochem. Biophys. Res. Commun. 219, 359-365
20. Finkelstein, E., Rosen, G. M., and Rauckman, E. J. (1982) Mol. Pharmacol. 21, 262-265
21. Roubaud, V., Sankarapandi, S., Kuppusamy, P., Tordo, P., and Zweier, J. L. (1997) Anal. Biochem. 247, 404-411
22. Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., and Snyder, S. H. (1991) Nature 351, 714-718
23. Cho, H. J., Xie, Q.-w., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., and Nathan, C. (1992) J. Exp. Med. 176, 599-604
24. Abu-Soud, H. M., Yoho, L. L., and Stuehr, D. J. (1994) J. Biol. Chem. 269, 32047-32050
25. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 1620-1624
26. Prough, R. A., and Masters, B. S. S. (1973) Ann. N. Y. Acad. Sci. 212, 89-93
27. Nishibayashi, H., Omura, T., and Sato, R. (1963) Biochim. Biophys. Acta 67, 520-522
28. Masters, B. S. S., Bilimoria, M. H., Kamin, H., and Gibson, Q. H. (1965) J. Biol. Chem. 240, 4081-4088
29. Vasquez-Vivar, J., Martasek P., Hogg N., Masters B. S. S., Pritchard, K. A., Jr., and Kalyanaraman B. (1997) Biochemistry 36, 11293-11297