A Conserved Val to Ile Switch near the Heme Pocket of Animal and Bacterial Nitric-oxide Synthases Helps Determine Their Distinct Catalytic Profiles

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 19018-19025

  Wang, Zhi Qiang ^a   Wei, Chin Chuan ^a   Sharma, Manisha ^a   Pant, Kartikeya ^b   Crane, Brian R ^b   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; MIXTURES; NITROGEN OXIDES;

HEME-LIGAND COMPLEXES; STOPPED-FLOW SPECTROSCOPY;

BIOCHEMISTRY;

ARGININE; ARGININE DERIVATIVE; CITRULLINE; FERRIC ION; FERROUS ION; HEME; ISOLEUCINE; N HYDROXYARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS SUBTILIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; ELECTRICITY; ENZYME KINETICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; ANIMALS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; HEME; IRON; ISOLEUCINE; KINETICS; MICE; MODELS, CHEMICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; VALINE;

ANIMALIA; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 2442498473     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311663200     Document Type: Article

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