The mRNA of the NR1 subtype of glutamate receptor in Alzheimer's disease

Journal of Neural Transmission

Volumn 109, Issue 1, 2002, Pages 77-89

  Ellsworth, D L ^a   Coady, S A ^a   Chen, Wei ^b   Srinivasan, S R ^b   Elkasabany, A ^b   Gustat, J ^b   Boerwinkle, E ^c   Berenson, E ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Tulane Center for Cardiovascular Health   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Dementia; Glutamate genes; NMDA receptors

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBTYPE; SULFUR 35;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; OPTICAL DENSITY; PATHOGENESIS; PRIORITY JOURNAL; SUBICULUM; TEMPORAL LOBE; VIDEODENSITOMETRY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; TEMPORAL LOBE;

EID: 0036166948     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s702-002-8238-9     Document Type: Article

References (51)

1. The role of neural activity in synaptic development and its implications for adult brain function
2. Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease - An in situ hybridization study
3. Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits
4. Expression of the NMDA NR1 receptor in selected human brain regions
5. The central nervous system in motor neurone disease
6. Glutamate receptor dysregulation in the hippocampus of transgenic carrying mutated human amyloid precursor protein
7. Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease
8. Examination of the role of calcium in neuronal death
9. Biochemical studies of the structure and function of the N-methyl-D-aspartate subtype of glutamate receiptors
10. The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons
11. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease
12. Diagnostic criteria for Parkinson disease
13. Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases
14. 3H] glutamate binding
15. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis
16. Terminal coma affects messenger RNA detection in post mortem human temporal cortex
17. Editorial on consensus recommendations for the postmortem diagnosis of Alzheimers disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
18. Glutamate NMDA receptor NR1 subunit mRNA expression in Alzheimer's disease
19. The new neuropathology of degenerative frontotemporal dementias
20. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
21. Tissue pH as an indicator of mRNA preservation in human post-mortem brain
22. β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damages
23. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis
24. Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis
25. Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer's disease
26. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
27. Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples
28. Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
29. Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism
30. Calcium signaling in the ER: Its role in neuronal plasticity and neurodegenerative disorders
31. The Consortium to Establish a Registry for Alzheimers Disease (CERAD). II. Standardisation of the neuropathological assessment of Alzheimers disease
32. 3H] TCP binding sites in Alzheimer's disease
33. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
34. Consensus recommendations for the postmortem diagnosis of Alzheimers disease
35. The amyloid precursor protein gene: A neuropeptide gene with diverse functions in the central nervous system
36. The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents
37. The functions of the amyloid precursor protein gene
38. Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders
39. AMPA/Kainate receptor gene expression in normal and Alzheimer's disease hippocampus
40. Beta-amyloidosis in normal aging and transmitter signalling in human temporal lobe
41. NMDA receptor status in elderly normal individuals and those with Alzheimer's disease
42. Gene expression in Alzheimer neocortex as a function of age and pathologic severity
43. Increased levels of the Kunitz protease inhibitor containing BAPP mRNAs in rat brain following neurotoxic damage
44. The arrangement of glutamate receptors at excitatory synapses
45. Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity
46. Decreased expression of N-methyl-D-aspartate receptor messenger RNA in select regions of Alzheimer brain
47. N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease
48. Neuropathological classification of Huntington's disease
49. Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease
50. Expression of calbindin-D28k in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid beta-peptide
51. Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid induced seizures in rat hippocampus