Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

Brain Research

Volumn 1031, Issue 2, 2005, Pages 222-228

  Kokubo, Hideko ^a,b   Kayed, Rakez ^c   Glabe, Charles G ^c   Yamaguchi, Haruyasu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b Geriat Research Institute Hospital   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer; Amyloid ; Immunoelectron microscope; Oligomer; Synapse

Indexed keywords

AMYLOID BETA PROTEIN; OLIGOMER; PROTEIN ANTIBODY;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CASE REPORT; CELL DENSITY; CELL ULTRASTRUCTURE; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; HUMAN; HUMAN TISSUE; IMMUNITY; IMMUNOELECTRON MICROSCOPY; NERVE FIBER; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SENILE PLAQUE; SYNAPSE; AGED; BRAIN; COMPARATIVE STUDY; PATHOLOGY; SYNAPTOSOME; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AXONS; BRAIN; HUMANS; MICROSCOPY, IMMUNOELECTRON; PRESYNAPTIC TERMINALS; SENILE PLAQUES;

EID: 11844300395     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.10.041     Document Type: Article

References (22)

1. P.F. Chapman, G.L. White, M.W. Jones, D. Cooper-Blacketer, V.J. Marshall, M. Irizarry, L. Younkin, M.A. Good, T.V. Bliss, B.T. Hyman, S.G. Younkin, and K.K. Hsiao Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice Nat. Neurosci. 2 1999 271 276
2. A.Y. Hsia, E. Masliah, L. McConlogue, G.Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R.C. Malenka, R.A. Nicoll, and L. Mucke Plaque-independent disruption of neural circuits in Alzheimer's disease mouse model Proc. Natl. Acad. Sci. U. S. A. 96 1999 3228 3233
3. N. Iwata, H. Mizukami, K. Shirotani, Y. Takaki, S. Muramatsu, B. Lu, N.P. Gerard, C. Gerard, K. Ozawa, and T.C. Saido Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-β peptide in mouse brain J. Neurosci. 24 2004 991 998
4. A. Kakio, S. Nishimoto, Y. Kozutsumi, and K. Matsuzaki Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes Biochem. Biophys. Res. Commun. 303 2003 514 518
5. R. Kayed, E. Head, J.L. Thompson, T.M. Mclntire, S.C. Milton, C.W. Cotman, and C.G. Glabe Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 2003 486 489
6. H. Kokubo, T.C. Saido, N. Iwata, J.B. Helms, R. Shinohara, H. Yamaguchi, Part of membrane-bound Aβ exists in rafts within senile plaques in Tg2576 mouse brain, Neurobiol. Aging, in press.
7. Y.M. Kuo, M.R. Emmerling, C. Vigo-Pelfrey, T.C. Kasunic, J.B. Kirkpatrick, G.H. Murdoch, M.J. Ball, and A.E. Roher Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains J. Biol. Chem. 271 1996 4077 4081
8. O. Lazarov, M. Lee, D.A. Peterson, and S.S. Sisodia Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice J. Neurosci. 22 2002 9785 9793
9. S.J. Lee, U. Liyanage, P.E. Bickel, W. Xia, P.T. Lansbury Jr., and K.S. Kosik A detergent-insoluble membrane compartment contains Aβ in vivo Nat. Med. 34 1998 730 734
10. A. Lorenzo, and B.A. Yankner Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red Proc. Natl. Acad. Sci. U. S. A. 91 1994 12243 12247
11. L.F. Lue, Y.M. Kuo, A.E. Roher, L. Brachova, Y. Shen, L. Sue, T. Beach, J.H. Kurth, R.E. Rydel, and J. Rogers Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease Am. J. Pathol. 155 1999 853 862
12. C.A. McLean, R.A. Cherny, F.W. Fraser, S.J. Fuller, M.J. Smith, K. Beyreuther, A.I. Bush, and C.L. Masters Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Ann. Neurol. 46 1999 860 866
13. T. Mizuno, M. Nakata, H. Naiki, M. Michikawa, R. Wang, C. Haass, and K. Yanagisawa Cholesterol-dependent generation of a seeding amyloid β protein in cell culture J. Biol. Chem. 274 1999 15110 15114
14. M. Morishima-Kawashima, and Y. Ihara The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells Biochemistry 37 1998 15247 15253
15. D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
16. C.I. Sze, J.C. Troncoso, C. Kawas, P. Mouton, D.L. Price, and L.J. Martin Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease J. Neuropathol. Exp. Neurol. 56 1997 933 944
17. R.H. Takahashi, C.G. Almeida, P.F. Kearey, F. Yu, M.T. Lin, T.A. Milner, and G.K. Gouras Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain J. Neurosci. 24 2004 3592 3599
18. D.M. Walsh, B.P. Tseng, R.E. Rydel, M.B. Podlisny, and D.J. Selkoe The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain Biochemistry 39 2000 10831 10839
19. D.M. Walsh, I. Klyubin, J.V. Fedeeva, W.K. Cullen, R. Anwyl, M.S. Wolfe, M.J. Rowan, and D.J. Selkoe Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535 539
20. D.S. Wang, N. Iwata, E. Hama, T.C. Saido, and D.W. Dickson Oxidized neprilysin in aging and Alzheimer's disease brains Biochem. Biophys. Res. Commun. 310 2003 236 241
21. H. Yamaguchi, M.L.C. Maat-Schieman, S.G. van Duinen, F.A. Prins, P. Neeskens, R. Natté, and R.A.C. Roos Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects J. Neuropathol. Exp. Neurol. 59 2000 723 732
22. K. Yasojima, H. Akiyama, E.G. McGeer, and P.L. McGeer Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide Neurosci. Lett. 297 2001 97 100