Aβ3 associated neuropil changes: Correlation with neuronal loss and dementia

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 12, 1998, Pages 1122-1130

  Knowles, Roger B ^a   Gomez Isla, Teresa ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer disease; Amyloid protein; Neurofibrillary tangles; Neurofilament proteins; Neuropil threads

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; NEUROPATHOLOGY; NEUROPIL; PRIORITY JOURNAL; PROTEIN DETERMINATION; CASE CONTROL STUDY; CELL DEATH; DENDRITE; METABOLISM; NERVE CELL; NEURITE; NEUROFIBRILLARY TANGLE; PATHOLOGY; STATISTICAL MODEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CASE-CONTROL STUDIES; CELL DEATH; DENDRITES; HUMANS; IMMUNOHISTOCHEMISTRY; LINEAR MODELS; NEURITES; NEUROFIBRILLARY TANGLES; NEURONS; NEUROPIL;

EID: 0031593784     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199812000-00003     Document Type: Article

References (35)

1. Dickson DW. The pathogenesis of senile plaques. J Neuropathol Exp Neurol 1997;56:321-39
2. Hyman BT, Marzloff K, Arriagada PV. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol. 1993;52:594-600
3. Goedert M, Trojanowski JQ, Lee VM-Y. Tau protein and the neurofibrillary pathology of Alzheimer's disease, in Molecular Mechanisms of Dementia. In: Wasco W, Tanzi RE, eds. Totowa, NJ: Humana Press, 1997:199-218
4. Kosik KS, Greenberg SM. Tau protein and Alzheimer's disease. In: Terry RD, Katzman R, and Bick KL, eds. Alzheimer Disease. New York: Raven Press, 1994:335-44
5. Schmidt ML, DiDario AG, Lee VM-Y, Trojanowski JQ. An extensive network of PHF tau-rich dystrophic neuntes permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease. FEBS Letters 1994;344:69-73
6. Goate A, Chartier-Harlin M-C. Mullan M. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-7
7. Chartier-Harlin M-C, Crawford F, Houlden H, et al. Early-onset Alzheimer's disease caused by mutation at codon 717 of the ∫-amyloid precursor protein gene. Nature 1991;353:844-46
8. Murrell J, Farlow M, Ghetti B, Benson MD. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991;254:97-99
9. Selkoe D. The molecular pathology of Alzheimer's disease. Neuron 1991;6:487-98
10. Mann DMA, Iwatsubo T, Cairns NJ, et al. Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: predominance of Aβ42(43). Ann Neurol 1996;40:149-56
11. Lemere CA, Lopera F, Kosik KS, et al. The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nature Medicine 1996;2:1146-50
12. Gomez-Isla T, Wasco W, Pettingell WP, et al. Identification of a novel Alzheimer's disease-Associated presenilin 1 gene mutation: Increased β-Amyloid and neurofibrillary pathological changes. Ann Neurol 1997;41:809-13
13. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 1990;250:279-82
14. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. Aggregation related toxicity of synthetic β-amyloid protein in hippocampal cultures. Eur J Pharmacol 1991;207:367-68
15. Cotman CW, Pike CJ., β-amyloid and its contributions to neuro-degeneration in Alzheimer's disease, In: Terry RD, Katzman R, and Bick KL, eds. Alzheimer Disease. New York: Raven Press, 1994: 305-15
16. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer disease. Neurology 1992;42:631-39
17. Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in cerebral cortex of patients with Alzheimer's disease. Cerebral Cortex 1991;1:103-16
18. Braak H, Braak E. Neuropathological staging of Alzheimer related changes. Acta Neuropathol 1991;82:239-59
19. Hof PR, Cox K, Morrison JH. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol 1990;301:44-54
20. Arriagada PV, Marzloff K, Hyman BT. Distribution of Alzheimer-type pathological changes in nondemented elderly matches the pattern of Alzheimer's disease. Neurology 1992;42:1681-88
21. Hyman BT, Tanzi RE. Amyloid, dementia and Alzheimer's disease. Curr Opin Neurol Neurosurg 1992;5:88-93
22. Nagy Z, Esiri MM, Jobst KA, et al. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia 1995;6:21-31
23. Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Annals of Neurology 1997;41:17-24
24. Cummings BJ, Cotman CW. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet 1995;346:1524-28
25. Irizarry MC, McNamara M, Fedorchak K, Hsiao K, Hyman BT. APP-sw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. Journal of Neuropathology and Experimental Neurology 1997;56:965-73
26. Irizarry MC. Soriano F, McNamara M, et al. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717f (PDAPP) transgenic mouse. J Neurosci 1997;17:7053-59
27. Wolozin BL, Pruchnicki A, Dickson DW, Davies P. A neuronal antigen in the brains of patients with Alzheimer's disease. Science 1986;232:648-50
28. Campbell MJ, Hof PR, Morrison JH. A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein. Brain Research 1991;539:133-36
29. Mirra SS, Heyman A, McKeel D, et. al. The consortium establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991;41:479-86
30. Barnes CL, Pandya DN. Efferent cortical connections of multimodal cortex of the superior temporal sulcus in the rhesus monkey. J Comp Neurol 1992;318:222-44
31. Li Y-T, Woodruff-Pak DS, Trojanowski JQ. Amyloid plaques in cerebellar cortex and the integrity of purkinje cell dendrites. Neurobiology of Aging 1994;15:1-9
32. Dickson DW, Crystal H, Bevona C, Honer W, Vincent I, Davies P. Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 1995;16:285-98
33. Younkin SG. Evidence that Aβ42 is the real culprit in Alzheimer's Disease. Ann Neurol 1995;37:287-88
34. Dickson DW, Ivanushkin A, Heitner J, Yen S-H, Davies P. Apolipoprotein-E immunoreactivity is increased in deposits of Alzheimer's disease, but not pathological aging or diffuse Lewy body disease. In Iqbal H, Mortimer JA, Winblad B, Wisniewski HM, eds. Research Advances in Alzheimer's disease and related disorders. New York: John Wiley & Sons, 1995:371-83
35. Mattiace LA, Davies P, Yen S-H, Dickson DW. Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol 1990:80: 493-98