β-amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons

Journal of Neurophysiology

Volumn 93, Issue 6, 2005, Pages 3102-3111

  Tyszkiewicz, Joanna P ^a   Yan, Zhen ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; AMYLOID BETA PROTEIN; DICARBOXYLIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; COGNITION; ENZYME REGULATION; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMORY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN METABOLISM; PYRAMIDAL NERVE CELL; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PREFRONTAL CORTEX; PROTEIN KINASE C; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 19344374239     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00939.2004     Document Type: Article

References (62)

1. Anwyl R. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Rev 29: 83-120, 1999.
2. Aiba A, Kano M, Chen C, Stanton ME, Fox GD, Herrup K, Zwingman TA, and Tonegawa S. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79: 377-388, 1994.
3. Bashir ZI, Bortolotto ZA, Davies CH, Berretta N, Irving AJ, Seal AJ, Henley JM, Jane DE, Watkins JC, and Collingridge GL. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363: 347-350, 1993.
4. Battaini F, Pascale A, Paoletti R, and Govoni S. The role of anchoring protein RACK1 in PKC activation in the ageing rat brain. Trends Neurosci 20: 410-415, 1997.
5. Bolshakov VY, Carboni L, Cobb MH, Siegelbaum SA, and Belardetti F. Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nat Neurosci 3: 1107-1112, 2000.
6. Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, and Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 21: 1013-1033, 2001.
7. Bruno V, Ksiazek I, Battaglia G, Lukic S, Leonhardt T, Sauer D, Gasparini F, Kuhn R, Nicoletti F, and Flor PJ. Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective. Neuropharmacology 39: 2223-2230, 2000.
8. Cartmell J and Schoepp DD. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 75: 889-907, 2000.
9. Cho K and Bashir ZI. Cooperation between mglu receptors: a depressing mechanism? Trends Neurosci 25: 405-411, 2002.
10. Conn PJ. Physiological roles and therapeutic potential of metabotropic glutamate receptors. Ann NY Acad Sci. 1003: 12-21, 2003.
11. Conn PJ and Pin JP. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 7: 205-237, 1997.
12. Constantinidis C, Williams GV, and Goldman-Rakic PS. Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex. J Neurophysiol 88: 3487-3497, 2002.
13. Copani A, Bruno V, Battaglia G, Leanza G, Pellitteri R, Russo A, Stanzani S, and Nicoletti F. Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide. Mol Pharmacol. 47: 890-7, 1995.
14. Cowburn RF, O'Neill C, Bonkale WL, Ohm TG, and Fastbom J. Receptor-G-protein signalling in Alzheimer's disease. Biochem Soc Symp 67: 163-175, 2001.
15. Eichholtz T, de Bont DB, de Widt J, Liskamp RM, and Ploegh HL. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J Biol Chem 268: 1982-1986, 1993.
16. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, and Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
17. A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J Neurosci 21: 6502-6511, 2001.
18. Fowler CJ, Cowburn RF, Garlind A, Winblad B, and O'Neill C. Disturbances in signal transduction mechanisms in Alzheimer's disease. Mol Cell Biochem 149: 287-292, 1995.
19. Fuster JM. The prefrontal cortex-an update: time is of the essence. Neuron 30: 319-333, 2001.
20. Glass DB, Cheng HC, Mende-Mueller L, Reed J, and Walsh DA. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem. 264: 8802-8810, 1989.
21. Gu Z, Zhong P, and Yan Z. Activation of muscarinic receptors inhibits β-amyloid peptide-induced signaling in cortical slices. J Biol Chem 278: 17546-17556, 2003.
22. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, and Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 96: 3228-3233, 1999.
23. Lee H, Zhu X, O'Neill MJ, Webber K, Casadesus G, Marlatt M, Raina AK, Perry G, and Smith MA. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta Neurobiol Exp 64: 89-98, 2004.
24. Lee RK, Wurtman RJ, Cox AJ, and Nitsch RM. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci USA 92: 8083-8087, 1995.
25. Lee W, Boo JH, Jung MW, Park SD, Kim YH, Kim SU, and Mook-Jung I. Amyloid beta peptide directly inhibits PKC activation. Mol Cell Neurosci 26: 222-231, 2004.
26. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, and Roder JC. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17: 5196-5205, 1997.
27. Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, and Rogers J. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155: 853-862, 1999.
28. Malenka RC and Nicoll RA. Long-term potentiation - a decade of progress? Science 285: 1870-1874, 1999.
29. Mannaioni G, Marino MJ, Valenti O, Traynelis SF, and Conn PJ. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J Neurosci 21: 5925-5934, 2001.
30. Marek GJ, Wright RA, Schoepp DD, Monn JA, and Aghajanian GK. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. J Pharmacol Exp Ther 292: 76-87, 2000.
31. McBain CJ, DiChiara TJ, and Kauer JA. Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission. J Neurosci 14: 4433-4445, 1994.
32. McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, and Masters CL. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46: 860-866, 1999.
33. Miles R and Poncer JC. Metabotropic glutamate receptors mediate a post-tetanic excitation of guinea-pig hippocampal inhibitory neurons. J Physiol 463: 461-473, 1993.
34. Miller EK and Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci 24: 167-202, 2001.
35. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603, 1992.
36. Nakanishi S. Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13: 1031-1037, 1994.
37. Nicoletti F, Bruno V, Copani A, Casabona G, and Knöpfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19: 267-271, 1996.
38. Pascale A, Govoni S, and Battaini F. Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples. Mol Neurobiol 16: 49-62, 1998.
39. Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, and Cotman CW. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. Neurochem 64: 253-265, 1995.
40. Pin JP and Duvoisin R. The metabotropic glutamate receptors: structure and function. Neuropharmacology 34: 1-26, 1995.
41. Price DL and Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 21: 479-505, 1998.
42. Rao SG, Williams GV, and Goldman-Rakic PS. Destruction and creation off spatial tuning by disinhibition: GABA(A) blockage of prefrontal cortical neurons engaged by working memory. J Neurosci 20: 485-494, 2000.
43. Rush AM, Wu J, Rowan MJ, and Anwyl R. Group I metabotropic glutamate receptor (mGluR)-dependent long-term depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyrus in vitro. J Neurosci. 22: 6121-6128, 2002.
44. Selkoe DJ. Alzheimer's disease: genes, protein, and therapy. Physiol. Rev. 81: 741-766, 2001.
45. Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 298: 789-91, 2002.
46. Selkoe DJ and Schenk D. Alzheimer's Disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43: 545-584, 2003.
47. Semyanov A and Kullmann DM. Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors. Neuron 25: 663-672, 2000.
48. Small DH, Mok SS, and Bornstein JC. Alzheimer's disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2: 595-598, 2001.
49. Tanaka C and Nishizuka Y. The protein kinase C family for neuronal signaling. Annu Rev Neurosci 17: 551-567, 1994.
50. Terzi E, Holzemann G, and Seelig J. Reversible random coil-beta-sheet transition of the Alzheimer beta-amyloid fragment (25-35). Biochemistry 33: 1345-1350, 1994.
51. Tyszkiewicz JP, Gu Z, Wang X, Cai X, and Yan Z. Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex. J Physiol 554: 765-777, 2004.
52. Valenti O, Marino MJ, Wittmann M, Lis E, DiLella AG, Kinney GG, and Conn PJ. Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci 23: 7218-26, 2003.
53. van Hooft JA, Giuffrida R, Blatow M, and Monyer H. Differential expression of group I metabotropic glutamate receptors in functionally distinct hippocampal interneurons. J Neurosci 20: 3544-3551, 2000.
54. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, and Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-539, 2002.
55. Wang Q, Walsh D, Rowan MJ, Selkoe DJ, and Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci 24: 3370-3378, 2004.
56. 4 signaling in prefrontal cortex. J Neurosci 23: 9852-9861, 2003.
57. Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, and Greengard P. Protein phosphatase I modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nat Neurosci 2: 13-17, 1999.
58. A currents in striatal cholinergic interneurons through a PKA/PP1 cascade. Neuron 19: 1115-1126, 1997.
59. Yankner BA, Duffy LK, and Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250: 279-282, 1990.
60. Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, and Nakanishi S. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273: 645-647, 1996.
61. Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL, and Lee JC. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem 272: 12116-21, 1997.
62. Zhong P, Gu Z, Wang X, Jiang H, Feng J, and Yan Z. Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J Biol Chem 278: 26888-26896, 2003.