메뉴 건너뛰기




Volumn 7, Issue 4, 1996, Pages 226-232

Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in alzheimer’s disease

Author keywords

Alzheimer s disease; Dementia; Hippocampus; Limbic system; Synapses

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; AUTOPSY; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; DENTATE GYRUS; ELECTRON MICROSCOPY; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SYNAPSE;

EID: 0029793008     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000106884     Document Type: Article
Times cited : (90)

References (51)
  • 1
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW: Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 1990;27:457-464.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • Dekosky, S.T.1    Scheff, S.W.2
  • 2
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R: Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991;30:572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 3
    • 0026549426 scopus 로고
    • Alteration in the pattern of nerve terminal protein intmunoreac-tivity in the pcrforant pathway in Alzheimer’s disease and in rats after entorhinal lesions
    • Cabalka LM, Hyman BT, Goodlett CR, Ritchie TC, Van Hocsen GW: Alteration in the pattern of nerve terminal protein intmunoreac-tivity in the pcrforant pathway in Alzheimer’s disease and in rats after entorhinal lesions. Neurobiol Aging 1992:13:283-291.
    • (1992) Neurobiol Aging , vol.13 , pp. 283-291
    • Cabalka, L.M.1    Hyman, B.T.2    Goodlett, C.R.3    Ritchie, T.C.4    Van Hocsen, G.W.5
  • 4
    • 0025218566 scopus 로고
    • Neuronal inputs to hippocampal formation in Alzheimer’s disease and in parkinsonism-demenlia complex on Guam
    • Goto S, Hirano A: Neuronal inputs to hippocampal formation in Alzheimer’s disease and in parkinsonism-demenlia complex on Guam. Acta Neuropathol 1990:79:545-550.
    • (1990) Acta Neuropathol , vol.79 , pp. 545-550
    • Goto, S.1    Hirano, A.2
  • 5
    • 0024595972 scopus 로고
    • Synaptic loss in Alzheimer’s disease and other dementias
    • Harnos J, DeGennaro L, Drachman D: Synaptic loss in Alzheimer’s disease and other dementias. Neurology 1989:39:355-361.
    • (1989) Neurology , vol.39 , pp. 355-361
    • Harnos, J.1    Degennaro, L.2    Drachman, D.3
  • 8
    • 0024364877 scopus 로고
    • Immunohistochcmical quantification of the synapse-related protein synaptophysin in Alzheimer disease
    • Masliah E, Terry R, DeTeresa R, Hansen L: Immunohistochcmical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neuro sci Lett 1989:103:234- 239.
    • (1989) Neuro Sci Lett , vol.103
    • Masliah, E.1    Terry, R.2    Deteresa, R.3    Hansen, L.4
  • 9
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysin-like immunorcactivity in Alzheimer’s disease
    • Masliah E, Terry RD, Alford M, DeTeresa R, Hansen LA: Cortical and subcortical patterns of synaptophysin-like immunorcactivity in Alzheimer’s disease. Ant J Pathol 1991; 138: 235-246.
    • (1991) Ant J Pathol , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    Deteresa, R.4    Hansen, L.A.5
  • 10
  • 11
    • 0027229615 scopus 로고
    • Quantitative assessment of the synaptophysin imrnu-no-reactivity of the cortical neuropil in various ncurodcgcnerativc disorders with dementia
    • Zhan S-S, Beyreuther K, Schmitt HP: Quantitative assessment of the synaptophysin imrnu-no-reactivity of the cortical neuropil in various ncurodcgcnerativc disorders with dementia. Dementia 1993:4:66-74.
    • (1993) Dementia , vol.4 , pp. 66-74
    • Zhan, S.-S.1    Beyreuther, K.2    Schmitt, H.P.3
  • 12
    • 0023106967 scopus 로고
    • A quantitative morphomctric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
    • Davies CA, Mann DMA, Sumpter PW, Yates PO: A quantitative morphomctric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 1987;78:151-164.
    • (1987) J Neurol Sci , vol.78 , pp. 151-164
    • Davies, C.A.1    Mann, D.2    Sumpter, P.W.3    Yates, P.O.4
  • 13
    • 0025283380 scopus 로고
    • Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease
    • Bertoni-Freddari C, Faltorctti P, Casoli T, Meier-Ruge W, Ulrich J: Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease. Brain Res 1990;517: 69-75.
    • (1990) Brain Res , vol.517 , pp. 69-75
    • Bertoni-Freddari, C.1    Faltorctti, P.2    Casoli, T.3    Meier-Ruge, W.4    Ulrich, J.5
  • 14
    • 0023024547 scopus 로고
    • Alzheimer’s disease: Maintenance of neuronal and synaptic densities in frontal cortical layers 11 and 111
    • Pauta-Barbosa MM, Saraiva A, Tavares MA, Borges MM, Verwer RWH: Alzheimer’s disease: maintenance of neuronal and synaptic densities in frontal cortical layers 11 and 111. Acta Neurol Scand 1986:74:404-408.
    • (1986) Acta Neurol Scand , vol.74 , pp. 404-408
    • Pauta-Barbosa, M.M.1    Saraiva, A.2    Tavares, M.A.3    Borges, M.M.4    Verwer, R.5
  • 15
    • 0025217385 scopus 로고
    • Quantitative assessment of cortical synaptic density in Alzheimer's disease
    • Schcff SW, DeKosky ST, Price DA: Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990:11: 29-37.
    • (1990) Neurobiol Aging , vol.11 , pp. 29-37
    • Schcff, S.W.1    Dekosky, S.T.2    Price, D.A.3
  • 16
    • 0027261146 scopus 로고
    • Quantitative assessment of synaptic density in the entorhi-nal cortex in Alzheimer's disease
    • Scheff SW, Sparks DL, Price DA: Quantitative assessment of synaptic density in the entorhi-nal cortex in Alzheimer's disease. Ann Neurol 1993:34:356-361.
    • (1993) Ann Neurol , vol.34 , pp. 356-361
    • Scheff, S.W.1    Sparks, D.L.2    Price, D.A.3
  • 17
    • 0001815909 scopus 로고
    • Pathology of Alzheimer’s disease
    • Caine DB (ed), Philadelphia. Saunders
    • Braak H, Braak E: Pathology of Alzheimer’s disease; in Caine DB (ed): Neurodegenerative Diseases. Philadelphia. Saunders, 1994, pp 585-613.
    • (1994) Neurodegenerative Diseases , pp. 585-613
    • Braak, H.1    Braak, E.2
  • 18
    • 0022397573 scopus 로고
    • Plasticity of hippocampal circuitry in Alzheimer’s disease
    • Geddes J, Monahan D, Cotman C, Lott IT, Kim R, Chui H: Plasticity of hippocampal circuitry in Alzheimer’s disease. Science 1985: 230:1179-1181.
    • (1985) Science , vol.230 , pp. 1179-1181
    • Geddes, J.1    Monahan, D.2    Cotman, C.3    Lott, I.T.4    Kim, R.5    Chui, H.6
  • 19
    • 0023095310 scopus 로고
    • Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
    • Hyman BT, Kromer LJ, Van Hoesen GW: Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease. Ann Neurol 1987;21:259-267.
    • (1987) Ann Neurol , vol.21 , pp. 259-267
    • Hyman, B.T.1    Kromer, L.J.2    Van Hoesen, G.W.3
  • 20
    • 0023734831 scopus 로고
    • Is senile dementia of the Alzheimer type associated with hippocampal plasticity
    • Represa A, Duychaerts C, Tremblay E, Hauw JJ, Ben-Ari Y: Is senile dementia of the Alzheimer type associated with hippocampal plasticity. Brain Res 1988:457:355-359.
    • (1988) Brain Res , vol.457 , pp. 355-359
    • Represa, A.1    Duychaerts, C.2    Tremblay, E.3    Hauw, J.J.4    Ben-Ari, Y.5
  • 21
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer’s disease
    • Khachaturian ZD: Diagnosis of Alzheimer’s disease. Arch Neurol 1985;42:1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.D.1
  • 22
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropa-thologic asscsscment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L: The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropa-thologic asscsscment of Alzheimer's disease. Neurology 1991;41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 23
    • 0000933894 scopus 로고
    • Determination of numerical density of perforated and nonperfo-rated synapses
    • Conn PM (ed), New York, Academic Press
    • Calverley RKS, Jones DG: Determination of numerical density of perforated and nonperfo-rated synapses; in Conn PM (ed): Quantitative and Qualitative Microscopy. New York, Academic Press, 1990, pp 155-172.
    • (1990) Quantitative and Qualitative Microscopy , pp. 155-172
    • Calverley, R.1    Jones, D.G.2
  • 27
    • 0027400026 scopus 로고
    • Synapse loss in the temporal lobe in Alzheimer’s disease
    • Scheff SW, Price D: Synapse loss in the temporal lobe in Alzheimer’s disease. Ann Neurol 1993;33:190-199.
    • (1993) Ann Neurol , vol.33 , pp. 190-199
    • Scheff, S.W.1    Price, D.2
  • 28
    • 0025733045 scopus 로고
    • Entorhinal cortex of the monkey: V. Projections to the dentate gyrus. Hippocampus, and subicular complex
    • Witter MP, Amaral DG: Entorhinal cortex of the monkey: V. Projections to the dentate gyrus. hippocampus, and subicular complex, J Comp Neurol 1991;307:437-459.
    • (1991) J Comp Neurol , vol.307 , pp. 437-459
    • Witter, M.P.1    Amaral, D.G.2
  • 29
    • 0002691008 scopus 로고
    • Synaptic reorganization after injury: The hippocampus as a model system
    • Seil FJ (ed), New York, Liss
    • Seheff SW: Synaptic reorganization after injury: The hippocampus as a model system; in Seil FJ (ed): Neural Regeneration and Transplantation. New York, Liss, 1989, pp 137-156.
    • (1989) Neural Regeneration and Transplantation , pp. 137-156
    • Seheff, S.W.1
  • 30
    • 0020068837 scopus 로고
    • Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and rcacqui-sition of normal synaptic density
    • Hoff SF, Scheff SW, Bernardo LS, Cotman CW: Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and rcacqui-sition of normal synaptic density. J Comp Neurol 1982;205:246-252.
    • (1982) J Comp Neurol , vol.205 , pp. 246-252
    • Hoff, S.F.1    Scheff, S.W.2    Bernardo, L.S.3    Cotman, C.W.4
  • 31
    • 0020074668 scopus 로고
    • Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response
    • Hoff SF, Scheff SW, Cotman CW: Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. demonstration of an impaired degeneration clearing response. J Comp Neurol 1982;205:253-259.
    • (1982) J Comp Neurol , vol.205 , pp. 253-259
    • Hoff, S.F.1    Scheff, S.W.2    Cotman, C.W.3
  • 32
    • 0018894530 scopus 로고
    • Decline of reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal
    • Scheff SW, Bernardo LS, Cotman CW: Decline of reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal. Brain Res 1980; 199:21-38.
    • (1980) Brain Res , vol.199 , pp. 21-38
    • Scheff, S.W.1    Bernardo, L.S.2    Cotman, C.W.3
  • 33
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL: Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation. Science 1984;225:1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 34
    • 0023260876 scopus 로고
    • The sep-to-hippocampal pathways in patients suffering from senile dementia of Alzheimer’s type. Evidence for neuronal plasticity?
    • Gertz H, Cervos-Navarro J, Ewald V: The sep-to-hippocampal pathways in patients suffering from senile dementia of Alzheimer’s type. Evidence for neuronal plasticity? Neurosci Lett 1987;76:228-232.
    • (1987) Neurosci Lett , vol.76 , pp. 228-232
    • Gertz, H.1    Cervos-Navarro, J.2    Ewald, V.3
  • 35
    • 0025599424 scopus 로고
    • Neuronal plasticity in normal aging and deficient plasticity in Alzheimer’s disease: A proposed intercellular signal cascade
    • Coleman P, Higgins G, Phelps C (eds), New York, Elsevier
    • Coleman PD, Rogers KE, Flood DG: Neuronal plasticity in normal aging and deficient plasticity in Alzheimer’s disease: a proposed intercellular signal cascade; in Coleman P, Higgins G, Phelps C (eds): Progress in brain Research. New York, Elsevier, 1990, pp 75-87.
    • (1990) Progress in Brain Research , pp. 75-87
    • Coleman, P.D.1    Rogers, K.E.2    Flood, D.G.3
  • 36
    • 0022385709 scopus 로고
    • Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the oldest old
    • Flood DG, Buell SJ, Defiore CH, Horwitz GJ, Coleman PD: Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the oldest old. Brain Res 1985; 345:366-368.
    • (1985) Brain Res , vol.345 , pp. 366-368
    • Flood, D.G.1    Buell, S.J.2    Defiore, C.H.3    Horwitz, G.J.4    Coleman, P.D.5
  • 37
    • 0023272355 scopus 로고
    • Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: A quantitative ultrastructural study
    • Adams I: Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: a quantitative ultrastructural study. Neurobiol Aging 1987;8:203-212.
    • (1987) Neurobiol Aging , vol.8 , pp. 203-212
    • Adams, I.1
  • 38
    • 0023589151 scopus 로고
    • Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans
    • Adams I: Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans. Brain Res 1987;424:343-351.
    • (1987) Brain Res , vol.424 , pp. 343-351
    • Adams, I.1
  • 39
    • 0023148496 scopus 로고
    • A scrial-section of perforated synapses in rat neocortex
    • Calverley RKS, Jones DG: A scrial-section of perforated synapses in rat neocortex. Cell Tissue Res 1987;247:565-572.
    • (1987) Cell Tissue Res , vol.247 , pp. 565-572
    • Calverley, R.1    Jones, D.G.2
  • 40
    • 0018190342 scopus 로고
    • Form of the postsynap-tic density
    • Cohen RS, Siekevitz P: Form of the postsynap-tic density. J Cell Biol 1978;78:36-46.
    • (1978) J Cell Biol , vol.78 , pp. 36-46
    • Cohen, R.S.1    Siekevitz, P.2
  • 41
    • 0018386142 scopus 로고
    • Stereological approach to the study of synapse morphometry with particular regard to estimating number in a volume and on a surface
    • Mayhew TM: Stereological approach to the study of synapse morphometry with particular regard to estimating number in a volume and on a surface. J Ncurocytol 1979;8:121-138.
    • (1979) J Ncurocytol , vol.8 , pp. 121-138
    • Mayhew, T.M.1
  • 42
    • 0014687804 scopus 로고
    • Kaiserman-Abramof IR: The small pyramidal neuron of the rat cerebral cortex
    • Peters A, Kaiserman-Abramof IR: The small pyramidal neuron of the rat cerebral cortex. Z Zellforsch 1969;100:487-506.
    • (1969) Z Zellforsch , vol.100 , pp. 487-506
    • Peters, A.1
  • 43
    • 0022997794 scopus 로고
    • A critical evaluation of methods for estimating the numerical density of synapses
    • deGroot DMG, Bierman PB: A critical evaluation of methods for estimating the numerical density of synapses. J Neurosci Methods 1986; 18:79-101.
    • (1986) J Neurosci Methods , vol.18 , pp. 79-101
    • Degroot, D.1    Bierman, P.B.2
  • 44
    • 0007565571 scopus 로고
    • Neuroimaging with CT and MRI in Alzheimer’s disease
    • Terry RD, Katzman R, Bick KL (eds), New York, Raven Press
    • Duara R: Neuroimaging with CT and MRI in Alzheimer’s disease: in Terry RD, Katzman R, Bick KL (eds): Alzheimer’s Disease. New York, Raven Press, 1994, pp 75-86.
    • (1994) Alzheimer’s Disease , pp. 75-86
    • Duara, R.1
  • 46
    • 0027473093 scopus 로고
    • In vitro MR microscopy of the hippocampus in Alzheimer’s disease
    • Huesgen CT, Burger PC, Crain BJ, Johnson GA: In vitro MR microscopy of the hippocampus in Alzheimer’s disease. Neurology 1993;43: 145-152.
    • (1993) Neurology , vol.43 , pp. 145-152
    • Huesgen, C.T.1    Burger, P.C.2    Crain, B.J.3    Johnson, G.A.4
  • 48
    • 0016613077 scopus 로고
    • The density of synapses and neurons in normal, mentally defective and aging human brains
    • Cragg BG: The density of synapses and neurons in normal, mentally defective and aging human brains. Brain 1975;98:81-90.
    • (1975) Brain , vol.98 , pp. 81-90
    • Cragg, B.G.1
  • 49
    • 0018376668 scopus 로고
    • Synaptic density in human frontal cortex - developmental changes and effects of aging
    • Huttenlocher PR: Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res 1979;163:195-205.
    • (1979) Brain Res , vol.163 , pp. 195-205
    • Huttenlocher, P.R.1
  • 50
    • 0021063927 scopus 로고
    • EM study of the numbers of cortical synapses in the brains of aging people and people with Alzheimer-type dementia
    • Gibson PH: EM study of the numbers of cortical synapses in the brains of aging people and people with Alzheimer-type dementia. Acta Neuropathol (Berlin) 1983;62:127-133.
    • (1983) Acta Neuropathol (Berlin) , vol.62 , pp. 127-133
    • Gibson, P.H.1
  • 51
    • 0027390458 scopus 로고
    • Quantitative synaptic alterations in the human neocortex during normal aging
    • Masliah E, Mallory M, Hansen L, DeTeresa R, Terry RD: Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 1993;43:192-197.
    • (1993) Neurology , vol.43 , pp. 192-197
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    Deteresa, R.4    Terry, R.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.