메뉴 건너뛰기




Volumn 80, Issue 6, 2006, Pages 1197-1213

The role of cytokines in hepatocellular carcinoma

Author keywords

Hepatitis; Immune; Inflammation; Liver; Metastasis

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; PEGINTERFERON; RIBAVIRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 33845420396     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0506297     Document Type: Review
Times cited : (257)

References (174)
  • 1
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill, F., Mantovani, A. (2001) Inflammation and cancer: back to Virchow? Lancet 357, 539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 2
    • 10744224063 scopus 로고    scopus 로고
    • The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients
    • Ohno, S., Inagawa, H., Dhar, D. K., Fujii, T., Ueda, S., Tachibana, M., Suzuki, N., Inoue, M., Soma, G., Nagasue, N. (2003) The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients. Anticancer Res. 23, 5015-5022.
    • (2003) Anticancer Res. , vol.23 , pp. 5015-5022
    • Ohno, S.1    Inagawa, H.2    Dhar, D.K.3    Fujii, T.4    Ueda, S.5    Tachibana, M.6    Suzuki, N.7    Inoue, M.8    Soma, G.9    Nagasue, N.10
  • 4
    • 0037569416 scopus 로고    scopus 로고
    • Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
    • Ribatti, D., Ennas, M. G., Vacca, A., Ferreli, F., Nico, B., Orru, S., Sirigu, P. (2003) Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur. J. Clin. Invest. 33, 420-425.
    • (2003) Eur. J. Clin. Invest. , vol.33 , pp. 420-425
    • Ribatti, D.1    Ennas, M.G.2    Vacca, A.3    Ferreli, F.4    Nico, B.5    Orru, S.6    Sirigu, P.7
  • 5
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek, R. D., Landers, R. J., Harris, A. L., Lewis, C. E. (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br. J. Cancer 79, 991-995.
    • (1999) Br. J. Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 6
    • 0034082042 scopus 로고    scopus 로고
    • Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma
    • Imada, A., Shijubo, N., Kojima, H., Abe, S. (2000) Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma. Eur. Respir. J. 15, 1087-1093.
    • (2000) Eur. Respir. J. , vol.15 , pp. 1087-1093
    • Imada, A.1    Shijubo, N.2    Kojima, H.3    Abe, S.4
  • 7
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis, C. E., Pollard, J. W. (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66, 605-612.
    • (2006) Cancer Res. , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 8
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M., Werb, Z. (2002) Inflammation and cancer. Nature 420, 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 9
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill, F., Charles, K. A., Mantovani, A. (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7, 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 10
    • 4544322522 scopus 로고    scopus 로고
    • Inflammatory exposure and historical changes in human life-spans
    • Finch, C. E., Crimmins, E. M. (2004) Inflammatory exposure and historical changes in human life-spans. Science 305, 1736-1739.
    • (2004) Science , vol.305 , pp. 1736-1739
    • Finch, C.E.1    Crimmins, E.M.2
  • 12
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise
    • Dannenberg, A. J., Subbaramaiah, K. (2003) Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell 4, 431-436.
    • (2003) Cancer Cell , vol.4 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 14
    • 0034083566 scopus 로고    scopus 로고
    • Regulation and antimetastatic functions of liver-associated natural killer cells
    • Wiltrout, R. H. (2000) Regulation and antimetastatic functions of liver-associated natural killer cells. Immunol. Rev. 174, 63-76.
    • (2000) Immunol. Rev. , vol.174 , pp. 63-76
    • Wiltrout, R.H.1
  • 16
    • 25844490025 scopus 로고    scopus 로고
    • The interplay between innate and adaptive immunity regulates cancer development
    • De Visser, K. E., Coussens, L. M. (2005) The interplay between innate and adaptive immunity regulates cancer development. Cancer Immunol. Immunother. 54, 1143-1152.
    • (2005) Cancer Immunol. Immunother. , vol.54 , pp. 1143-1152
    • De Visser, K.E.1    Coussens, L.M.2
  • 17
    • 20444463535 scopus 로고    scopus 로고
    • Mechanisms of disease: Inflammatory mediators and cancer prevention
    • Mann, J. R., Backlund, M. G., DuBois, R. N. (2005) Mechanisms of disease: inflammatory mediators and cancer prevention. Nat. Clin. Pract. Oncol. 2, 202-210.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , pp. 202-210
    • Mann, J.R.1    Backlund, M.G.2    DuBois, R.N.3
  • 18
    • 0032843811 scopus 로고    scopus 로고
    • Estimates of the worldwide mortality from 25 cancers in 1990
    • Pisani, P., Parkin, D. M., Bray, F., Ferlay, J. (1999) Estimates of the worldwide mortality from 25 cancers in 1990. Int. J. Cancer 83, 18-29.
    • (1999) Int. J. Cancer , vol.83 , pp. 18-29
    • Pisani, P.1    Parkin, D.M.2    Bray, F.3    Ferlay, J.4
  • 19
    • 0034893404 scopus 로고    scopus 로고
    • Hepatocellular carcinoma - Cause, treatment and metastasis
    • Tang, Z. Y. (2001) Hepatocellular carcinoma - cause, treatment and metastasis. World J. Gastroenterol. 7, 445-454.
    • (2001) World J. Gastroenterol. , vol.7 , pp. 445-454
    • Tang, Z.Y.1
  • 20
    • 0025222726 scopus 로고
    • Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases
    • Yuki, K., Hirohashi, S., Sakamoto, M., Kanai, T., Shimosato, Y. (1990) Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 66, 2174-2179.
    • (1990) Cancer , vol.66 , pp. 2174-2179
    • Yuki, K.1    Hirohashi, S.2    Sakamoto, M.3    Kanai, T.4    Shimosato, Y.5
  • 21
  • 22
    • 5044234897 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis
    • Anzola, M. (2004) Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J. Viral Hepat. 11, 383-393.
    • (2004) J. Viral Hepat. , vol.11 , pp. 383-393
    • Anzola, M.1
  • 23
    • 0030823524 scopus 로고    scopus 로고
    • Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: A prospective study
    • Tsai, J. F., Jeng, J. E., Ho, M. S., Chang, W. Y., Hsieh, M. Y., Lin, Z. Y., Tsai, J. H. (1997) Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: a prospective study. Br. J. Cancer 76, 968-974.
    • (1997) Br. J. Cancer , vol.76 , pp. 968-974
    • Tsai, J.F.1    Jeng, J.E.2    Ho, M.S.3    Chang, W.Y.4    Hsieh, M.Y.5    Lin, Z.Y.6    Tsai, J.H.7
  • 24
    • 0032579547 scopus 로고    scopus 로고
    • A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma
    • Donato, F., Boffetta, P., Puoti, M. (1998) A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma. Int. J. Cancer 75, 347-354.
    • (1998) Int. J. Cancer , vol.75 , pp. 347-354
    • Donato, F.1    Boffetta, P.2    Puoti, M.3
  • 26
    • 0030912338 scopus 로고    scopus 로고
    • The molecular virology of hepatitis C
    • Major, M. E., Feinstone, S. M. (1997) The molecular virology of hepatitis C. Hepatology 25, 1527-1538.
    • (1997) Hepatology , vol.25 , pp. 1527-1538
    • Major, M.E.1    Feinstone, S.M.2
  • 27
    • 0032583933 scopus 로고    scopus 로고
    • Hepatitis C
    • Di Bisceglie, A. M. (1998) Hepatitis C. Lancet 351, 351-355.
    • (1998) Lancet , vol.351 , pp. 351-355
    • Di Bisceglie, A.M.1
  • 31
    • 33846322772 scopus 로고    scopus 로고
    • Mutual confounding and interactive effects between hepatitis C and hepatitis B viral infections in hepatocellular carcinogenesis: A population-based case-control study in Taiwan
    • Sun, C. A., Farzadegan, H., You, S. L., Lu, S. N., Wu, M. H., Wolfe, L., Hardy, W., Huang, G. T., Yang, P. M., Lee, H., Chen, C. J. (1996) Mutual confounding and interactive effects between hepatitis C and hepatitis B viral infections in hepatocellular carcinogenesis: a population-based case-control study in Taiwan. Cancer Epidemiol. Biomarkers Prev. 5, 173-178.
    • (1996) Cancer Epidemiol. Biomarkers Prev. , vol.5 , pp. 173-178
    • Sun, C.A.1    Farzadegan, H.2    You, S.L.3    Lu, S.N.4    Wu, M.H.5    Wolfe, L.6    Hardy, W.7    Huang, G.T.8    Yang, P.M.9    Lee, H.10    Chen, C.J.11
  • 32
    • 0028299678 scopus 로고
    • Hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Chinese: A case-control study
    • Tsai, J. F., Jeng, J. E., Ho, M. S., Chang, W. Y., Lin, Z. Y., Tsai, J. H. (1994) Hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Chinese: a case-control study. Int. J. Cancer 56, 619-621.
    • (1994) Int. J. Cancer , vol.56 , pp. 619-621
    • Tsai, J.F.1    Jeng, J.E.2    Ho, M.S.3    Chang, W.Y.4    Lin, Z.Y.5    Tsai, J.H.6
  • 33
    • 12644304272 scopus 로고    scopus 로고
    • Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: A case-control study in Italy. Brescia HCC Study
    • Donato, F., Tagger, A., Chiesa, R., Ribero, M. L., Tomasoni, V., Fasola, M., Gelatti, U., Portera, G., Boffetta, P., Nardi, G. (1997) Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: a case-control study in Italy. Brescia HCC Study. Hepatology 26, 579-584.
    • (1997) Hepatology , vol.26 , pp. 579-584
    • Donato, F.1    Tagger, A.2    Chiesa, R.3    Ribero, M.L.4    Tomasoni, V.5    Fasola, M.6    Gelatti, U.7    Portera, G.8    Boffetta, P.9    Nardi, G.10
  • 34
    • 0033860678 scopus 로고    scopus 로고
    • Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    • Brechot, C., Gozuacik, D., Murakami, Y., Paterlini-Brechot, P. (2000) Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin. Cancer Biol. 10, 211-231.
    • (2000) Semin. Cancer Biol. , vol.10 , pp. 211-231
    • Brechot, C.1    Gozuacik, D.2    Murakami, Y.3    Paterlini-Brechot, P.4
  • 36
    • 0034060617 scopus 로고    scopus 로고
    • Viral carcinogenesis: Revelation of molecular mechanisms and etiology of human disease
    • Butel, J. S. (2000) Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. Carcinogenesis 21, 405-426.
    • (2000) Carcinogenesis , vol.21 , pp. 405-426
    • Butel, J.S.1
  • 37
    • 0033176296 scopus 로고    scopus 로고
    • The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis
    • (Review)
    • Andrisani, O. M., Barnabas, S. (1999) The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review). Int. J. Oncol. 15, 373-379.
    • (1999) Int. J. Oncol. , vol.15 , pp. 373-379
    • Andrisani, O.M.1    Barnabas, S.2
  • 38
    • 0032853956 scopus 로고    scopus 로고
    • Hepatitis B virus in hepatocarcinogenesis
    • Feitelson, M. A. (1999) Hepatitis B virus in hepatocarcinogenesis. J. Cell. Physiol. 181, 188-202.
    • (1999) J. Cell. Physiol. , vol.181 , pp. 188-202
    • Feitelson, M.A.1
  • 39
    • 17344381535 scopus 로고    scopus 로고
    • Hepatitis C virus biology
    • Giannini, C., Brechot, C. (2003) Hepatitis C virus biology. Cell Death Differ. 10, Suppl 1, S27-S38.
    • (2003) Cell Death Differ. , vol.10 , Issue.SUPPL. 1
    • Giannini, C.1    Brechot, C.2
  • 41
    • 0030008955 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor β 1-induced apoptosis
    • Tanaka, S., Wands, J. R. (1996) Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor β 1-induced apoptosis. Cancer Res. 56, 3391-3394.
    • (1996) Cancer Res. , vol.56 , pp. 3391-3394
    • Tanaka, S.1    Wands, J.R.2
  • 42
    • 0027080658 scopus 로고
    • Hepatitis C virus infection, HBsAg carrier state and hepatocellular carcinoma: Relative risk and population attributable risk from a case-control study in Italy
    • Stroffolini, T., Chiaramonte, M., Tiribelli, C., Villa, E., Simonetti, R. G., Rapicetta, M., Stazi, M. A., Bertin, T., Croce, S. L., Trande, P. (1992) Hepatitis C virus infection, HBsAg carrier state and hepatocellular carcinoma: relative risk and population attributable risk from a case-control study in Italy. J. Hepatol. 16, 360-363.
    • (1992) J. Hepatol. , vol.16 , pp. 360-363
    • Stroffolini, T.1    Chiaramonte, M.2    Tiribelli, C.3    Villa, E.4    Simonetti, R.G.5    Rapicetta, M.6    Stazi, M.A.7    Bertin, T.8    Croce, S.L.9    Trande, P.10
  • 46
    • 0034518533 scopus 로고    scopus 로고
    • Cellular immune response in HCV infection
    • Nakamura, I., Imawari, M. (2000) Cellular immune response in HCV infection. J. Gastroenterol. 35, 881-889.
    • (2000) J. Gastroenterol. , vol.35 , pp. 881-889
    • Nakamura, I.1    Imawari, M.2
  • 47
    • 0037325472 scopus 로고    scopus 로고
    • Immune responses in hepatitis B virus infection
    • Rehermann, B. (2003) Immune responses in hepatitis B virus infection. Semin. Liver Dis. 23, 21-38.
    • (2003) Semin. Liver Dis. , vol.23 , pp. 21-38
    • Rehermann, B.1
  • 48
    • 0034678409 scopus 로고    scopus 로고
    • Intrahepatic T cells in hepatitis B: Viral control versus liver cell injury
    • Rehermann, B. (2000) Intrahepatic T cells in hepatitis B: viral control versus liver cell injury. J. Exp. Med. 191, 1263-1268.
    • (2000) J. Exp. Med. , vol.191 , pp. 1263-1268
    • Rehermann, B.1
  • 50
    • 0036271116 scopus 로고    scopus 로고
    • Viral determinants and host immune responses in the pathogenesis of HBV infection
    • Rapicetta, M., Ferrari, C., Levrero, M. (2002) Viral determinants and host immune responses in the pathogenesis of HBV infection. J. Med. Virol. 67, 454-457.
    • (2002) J. Med. Virol. , vol.67 , pp. 454-457
    • Rapicetta, M.1    Ferrari, C.2    Levrero, M.3
  • 51
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R., Chisari, F. V. (1999) Viral clearance without destruction of infected cells during acute HBV infection. Science 284, 825-829.
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 52
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to γ-2/interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • Kakimi, K., Lane, T. E., Wieland, S., Asensio, V. C., Campbell, I. L., Chisari, F. V., Guidotti, L. G. (2001) Blocking chemokine responsive to γ-2/interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J. Exp. Med. 194, 1755-1766.
    • (2001) J. Exp. Med. , vol.194 , pp. 1755-1766
    • Kakimi, K.1    Lane, T.E.2    Wieland, S.3    Asensio, V.C.4    Campbell, I.L.5    Chisari, F.V.6    Guidotti, L.G.7
  • 55
    • 0036322490 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in hepatitis viral infection: Lessons from transgenic mouse studies
    • Koike, K. (2002) Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies. J. Gastroenterol. 37 (Suppl. 13), 55-64.
    • (2002) J. Gastroenterol. , vol.37 , Issue.SUPPL. 13 , pp. 55-64
    • Koike, K.1
  • 58
    • 0032823995 scopus 로고    scopus 로고
    • Natural and iatrogenic variation in hepatitis B virus
    • Ngui, S. L., Hallet, R., Teo, C. G. (1999) Natural and iatrogenic variation in hepatitis B virus. Rev. Med. Virol. 9, 183-209.
    • (1999) Rev. Med. Virol. , vol.9 , pp. 183-209
    • Ngui, S.L.1    Hallet, R.2    Teo, C.G.3
  • 60
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
    • Martell, M., Esteban, J. I., Quer, J., Genesca, J., Weiner, A., Esteban, R., Guardia, J., Gomez, J. (1992) Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J. Virol. 66, 3225-3229.
    • (1992) J. Virol. , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6    Guardia, J.7    Gomez, J.8
  • 62
    • 0028086591 scopus 로고
    • Cytotoxic T lymphocyte response to a wild-type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope
    • Bertoletti, A., Costanzo, A., Chisari, F. V., Levrero, M., Artini, M., Sette, A., Penna, A., Giuberti, T., Fiaccadori, F., Ferrari, C. (1994) Cytotoxic T lymphocyte response to a wild-type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J. Exp. Med. 180, 933-943.
    • (1994) J. Exp. Med. , vol.180 , pp. 933-943
    • Bertoletti, A.1    Costanzo, A.2    Chisari, F.V.3    Levrero, M.4    Artini, M.5    Sette, A.6    Penna, A.7    Giuberti, T.8    Fiaccadori, F.9    Ferrari, C.10
  • 63
  • 64
    • 0030914290 scopus 로고    scopus 로고
    • Understanding the mechanisms of sustained signaling and T cell activation
    • Lanzavecchia, A. (1997) Understanding the mechanisms of sustained signaling and T cell activation. J. Exp. Med. 185, 1717-1719.
    • (1997) J. Exp. Med. , vol.185 , pp. 1717-1719
    • Lanzavecchia, A.1
  • 65
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D., Allen, P. M. (1991) Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252, 1308-1310.
    • (1991) Science , vol.252 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 66
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J., Evavold, B. D., Allen, P. M. (1993) Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363, 156-159.
    • (1993) Nature , vol.363 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 67
    • 0035804226 scopus 로고    scopus 로고
    • Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis
    • Kim, Y. C., Song, K. S., Yoon, G., Nam, M. J., Ryu, W. S. (2001) Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene 20, 16-23.
    • (2001) Oncogene , vol.20 , pp. 16-23
    • Kim, Y.C.1    Song, K.S.2    Yoon, G.3    Nam, M.J.4    Ryu, W.S.5
  • 69
    • 23144449790 scopus 로고    scopus 로고
    • Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication
    • Wang, W., Budhu, A., Forgues, M., Wang, X. W. (2005) Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. Nat. Cell Biol. 7, 823-830.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 823-830
    • Wang, W.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 70
    • 0033556262 scopus 로고    scopus 로고
    • Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence
    • Large, M. K., Kittlesen, D. J., Hahn, Y. S. (1999) Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. J. Immunol. 162, 931-938.
    • (1999) J. Immunol. , vol.162 , pp. 931-938
    • Large, M.K.1    Kittlesen, D.J.2    Hahn, Y.S.3
  • 71
    • 0032906988 scopus 로고    scopus 로고
    • Hepatitis C virus core protein enhances NF-κB signal pathway triggering by lymphotoxin-β receptor ligand and tumor necrosis factor α
    • You, L. R., Chen, C. M., Lee, Y. H. W. (1999) Hepatitis C virus core protein enhances NF-κB signal pathway triggering by lymphotoxin-β receptor ligand and tumor necrosis factor α. J. Virol. 73, 1672-1681.
    • (1999) J. Virol. , vol.73 , pp. 1672-1681
    • You, L.R.1    Chen, C.M.2    Lee, Y.H.W.3
  • 72
    • 0035916008 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages
    • Lee, C. H., Choi, Y. H., Yang, S. H., Lee, C. W., Ha, S. J., Sung, Y. C. (2001) Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages. Virology 279, 271-279.
    • (2001) Virology , vol.279 , pp. 271-279
    • Lee, C.H.1    Choi, Y.H.2    Yang, S.H.3    Lee, C.W.4    Ha, S.J.5    Sung, Y.C.6
  • 73
    • 0036720777 scopus 로고    scopus 로고
    • Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model
    • Soguero, C., Joo, M., Chianese-Bullock, K. A., Nguyen, D. T., Tung, K., Hahn, Y. S. (2002) Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J. Virol. 76, 9345-9354.
    • (2002) J. Virol. , vol.76 , pp. 9345-9354
    • Soguero, C.1    Joo, M.2    Chianese-Bullock, K.A.3    Nguyen, D.T.4    Tung, K.5    Hahn, Y.S.6
  • 74
    • 33746467483 scopus 로고    scopus 로고
    • Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocyte
    • In press
    • Wu, C. G., Budhu, A., Chen, S., Zhou, X., Popescu, N. C., Valerie, K., Wang, X. W. (2006) Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocyte. Mol. Med., In press.
    • (2006) Mol. Med.
    • Wu, C.G.1    Budhu, A.2    Chen, S.3    Zhou, X.4    Popescu, N.C.5    Valerie, K.6    Wang, X.W.7
  • 75
    • 0034691609 scopus 로고    scopus 로고
    • Hepatitis C virus glycoprotein E2 binding to CD81: The role of E1E2 cleavage and protein glycosylation in bioactivity
    • Chan-Fook, C., Jiang, W. R., Clarke, B. E., Zitzmann, N., Maidens, C., McKeating, J. A., Jones, I. M. (2000) Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity. Virology 273, 60-66.
    • (2000) Virology , vol.273 , pp. 60-66
    • Chan-Fook, C.1    Jiang, W.R.2    Clarke, B.E.3    Zitzmann, N.4    Maidens, C.5    McKeating, J.A.6    Jones, I.M.7
  • 76
    • 0036017204 scopus 로고    scopus 로고
    • The nonstructural NS5A protein of hepatitis C virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesis
    • Reyes, G. R. (2002) The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis. J. Biomed. Sci. 9, 187-197.
    • (2002) J. Biomed. Sci. , vol.9 , pp. 187-197
    • Reyes, G.R.1
  • 80
    • 0028567172 scopus 로고
    • Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
    • Hagen, T. M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N., Chisari, F. V. (1994) Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 91, 12808-12812.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12808-12812
    • Hagen, T.M.1    Huang, S.2    Curnutte, J.3    Fowler, P.4    Martinez, V.5    Wehr, C.M.6    Ames, B.N.7    Chisari, F.V.8
  • 81
    • 0141540375 scopus 로고    scopus 로고
    • Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C
    • Kitaoka, S., Shiota, G., Kawasaki, H. (2003) Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C. Hepatogastroenterology 50, 1569-1574.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1569-1574
    • Kitaoka, S.1    Shiota, G.2    Kawasaki, H.3
  • 84
    • 0026770647 scopus 로고
    • Preoperative and postoperative cytokines in patients with cancer
    • Nakazaki, H. (1992) Preoperative and postoperative cytokines in patients with cancer. Cancer 70, 709-713.
    • (1992) Cancer , vol.70 , pp. 709-713
    • Nakazaki, H.1
  • 85
    • 0041589356 scopus 로고    scopus 로고
    • Serum cytokine profiles associated with clinical presentation in Vietnamese infected with hepatitis B virus
    • Song, l. H., Binh, V. Q., Duy, D. N., Kun, J. F., Bock, T. C., Kremsner, P. G., Luty, A. J. (2003) Serum cytokine profiles associated with clinical presentation in Vietnamese infected with hepatitis B virus. J. Clin. Virol. 28, 93-103.
    • (2003) J. Clin. Virol. , vol.28 , pp. 93-103
    • Song, L.H.1    Binh, V.Q.2    Duy, D.N.3    Kun, J.F.4    Bock, T.C.5    Kremsner, P.G.6    Luty, A.J.7
  • 86
    • 0029965546 scopus 로고    scopus 로고
    • Changes in tumor necrosis factor-a and interleukin-1 β production following liver surgery on cirrhotic patients
    • Sato, T., Asanuma, Y., Masaki, Y., Sato, Y., Hatakeyama, Y., Kusano, T., Koyama, K. (1996) Changes in tumor necrosis factor-a and interleukin-1 β production following liver surgery on cirrhotic patients. Hepatogastroenterology 43, 1148-1153.
    • (1996) Hepatogastroenterology , vol.43 , pp. 1148-1153
    • Sato, T.1    Asanuma, Y.2    Masaki, Y.3    Sato, Y.4    Hatakeyama, Y.5    Kusano, T.6    Koyama, K.7
  • 88
    • 0037864153 scopus 로고    scopus 로고
    • Impact of interleukin-1β genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    • Tanaka, Y., Furuta, T., Suzuki, S., Orito, E., Yeo, A. E., Hirashima, N., Sugauchi, F., Ueda, R., Mizokami, M. (2003) Impact of interleukin-1β genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan. J. Infect. Dis. 187, 1822-1825.
    • (2003) J. Infect. Dis. , vol.187 , pp. 1822-1825
    • Tanaka, Y.1    Furuta, T.2    Suzuki, S.3    Orito, E.4    Yeo, A.E.5    Hirashima, N.6    Sugauchi, F.7    Ueda, R.8    Mizokami, M.9
  • 89
    • 33644888000 scopus 로고    scopus 로고
    • Interleukin-1β gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection
    • Hirankarn, N., Kimkong, I., Kummee, P., Tangkijvanich, P., Poovorawan, Y. (2006) Interleukin-1β gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection. World J. Gastroenterol. 12, 776-779.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 776-779
    • Hirankarn, N.1    Kimkong, I.2    Kummee, P.3    Tangkijvanich, P.4    Poovorawan, Y.5
  • 90
    • 19944364896 scopus 로고    scopus 로고
    • Interleukin-2 gene expression is a new biological prognostic marker in hepatocellular carcinomas
    • Ikeguchi, M., Hirooka, Y. (2005) Interleukin-2 gene expression is a new biological prognostic marker in hepatocellular carcinomas. Onkologie 28, 255-259.
    • (2005) Onkologie , vol.28 , pp. 255-259
    • Ikeguchi, M.1    Hirooka, Y.2
  • 91
    • 0027265679 scopus 로고
    • Interferon-γ, interleukin (IL)-2 and IL-2 receptor expressions in hepatitis C virus-infected liver
    • Morshed, S. A., Fukuma, H., Kimura, Y., Watanabe, S., Nishioka, M. (1993) Interferon-γ, interleukin (IL)-2 and IL-2 receptor expressions in hepatitis C virus-infected liver. Gastroenterol. Jpn. 28, Suppl 5, 59-66.
    • (1993) Gastroenterol. Jpn. , vol.28 , Issue.SUPPL. 5 , pp. 59-66
    • Morshed, S.A.1    Fukuma, H.2    Kimura, Y.3    Watanabe, S.4    Nishioka, M.5
  • 92
    • 0345330205 scopus 로고    scopus 로고
    • Effects of splenectomy in patients with cirrhosis undergoing hepatic resection for hepatocellular carcinoma
    • Cao, Z. X., Chen, X. P., Wu, Z. D. (2003) Effects of splenectomy in patients with cirrhosis undergoing hepatic resection for hepatocellular carcinoma. World J. Gastroenterol. 9, 2460-2463.
    • (2003) World J. Gastroenterol. , vol.9 , pp. 2460-2463
    • Cao, Z.X.1    Chen, X.P.2    Wu, Z.D.3
  • 94
    • 0027273605 scopus 로고
    • Gene expression regulation for interferon-α in hepatocellular carcinoma
    • d'Arville, C. N., Nouri-Aria, K. T., Johnson, P., Williams, R. (1993) Gene expression regulation for interferon-α in hepatocellular carcinoma. J. Hepatol. 17, 339-346.
    • (1993) J. Hepatol. , vol.17 , pp. 339-346
    • D'Arville, C.N.1    Nouri-Aria, K.T.2    Johnson, P.3    Williams, R.4
  • 98
    • 13444253760 scopus 로고    scopus 로고
    • Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
    • Nieters, A., Yuan, J. M., Sun, C. L., Zhang, Z. Q., Stoehlmacher, J., Govindarajan, S., Yu, M. C. (2005) Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association. Cancer 103, 740-748.
    • (2005) Cancer , vol.103 , pp. 740-748
    • Nieters, A.1    Yuan, J.M.2    Sun, C.L.3    Zhang, Z.Q.4    Stoehlmacher, J.5    Govindarajan, S.6    Yu, M.C.7
  • 99
    • 0030770259 scopus 로고    scopus 로고
    • Serum levels of IL-10, IL-15 and soluble tumor necrosis factor-α (TNF-α) receptors in type C chronic liver disease
    • Kakumu, S., Okumura, A., Ishikawa, T., Yano, M., Enomoto, A., Nishimura, H., Yoshioka, K., Yoshika, Y. (1997) Serum levels of IL-10, IL-15 and soluble tumor necrosis factor-α (TNF-α) receptors in type C chronic liver disease. Clin. Exp. Immunol. 109, 458-463.
    • (1997) Clin. Exp. Immunol. , vol.109 , pp. 458-463
    • Kakumu, S.1    Okumura, A.2    Ishikawa, T.3    Yano, M.4    Enomoto, A.5    Nishimura, H.6    Yoshioka, K.7    Yoshika, Y.8
  • 101
    • 0032997106 scopus 로고    scopus 로고
    • Hepatic damage induced by transcatheter arterial chemoembolization elevates serum concentrations of macrophage-colony stimulating factor
    • Itoh, Y., Okanoue, T., Ohnishi, N., Nishioji, K., Sakamoto, S., Nagao, Y., Nakamura, H., Kirishima, T., Kashima, K. (1999) Hepatic damage induced by transcatheter arterial chemoembolization elevates serum concentrations of macrophage-colony stimulating factor. Liver 19, 97-103.
    • (1999) Liver , vol.19 , pp. 97-103
    • Itoh, Y.1    Okanoue, T.2    Ohnishi, N.3    Nishioji, K.4    Sakamoto, S.5    Nagao, Y.6    Nakamura, H.7    Kirishima, T.8    Kashima, K.9
  • 102
    • 0034121558 scopus 로고    scopus 로고
    • Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection
    • McGuinness, P. H., Painter, D., Davies, S., McCaughan, G. W. (2000) Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 46, 260-269.
    • (2000) Gut , vol.46 , pp. 260-269
    • McGuinness, P.H.1    Painter, D.2    Davies, S.3    McCaughan, G.W.4
  • 103
    • 4043102715 scopus 로고    scopus 로고
    • Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene
    • Ho, S. Y., Wang, Y. J., Chen, H. L., Chen, C. H., Chang, C. J., Wang, P. J., Chen, H. H., Guo, H. R. (2004) Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene. Cancer Causes Control 15, 657-663.
    • (2004) Cancer Causes Control , vol.15 , pp. 657-663
    • Ho, S.Y.1    Wang, Y.J.2    Chen, H.L.3    Chen, C.H.4    Chang, C.J.5    Wang, P.J.6    Chen, H.H.7    Guo, H.R.8
  • 105
    • 0030862033 scopus 로고    scopus 로고
    • The -308 tumor necrosis factor-α promoter polymorphism effects transcription
    • Kroeger, K. M., Carville, K. S., Abraham, L. J. (1997) The -308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol. Immunol. 34, 391-399.
    • (1997) Mol. Immunol. , vol.34 , pp. 391-399
    • Kroeger, K.M.1    Carville, K.S.2    Abraham, L.J.3
  • 107
    • 8444243261 scopus 로고    scopus 로고
    • Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets
    • Beckebaum, S., Zhang, X., Chen, X., Yu, Z., Frilling, A., Dworacki, G., Grosse-Wilde, H., Broelsch, C. E., Gerken, G., Cicinnati, V. R. (2004) Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets. Clin. Cancer Res. 10, 7260-7269.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7260-7269
    • Beckebaum, S.1    Zhang, X.2    Chen, X.3    Yu, Z.4    Frilling, A.5    Dworacki, G.6    Grosse-Wilde, H.7    Broelsch, C.E.8    Gerken, G.9    Cicinnati, V.R.10
  • 108
    • 0034028927 scopus 로고    scopus 로고
    • Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma
    • Chau, G. Y., Wu, C. W., Lui, W. Y., Chang, T. J., Kao, H. L., Wu, L. H., King, K. L., Loong, C. C., Hsia, C. Y., Chi, C. W. (2000) Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma. Ann. Surg. 231, 552-558.
    • (2000) Ann. Surg. , vol.231 , pp. 552-558
    • Chau, G.Y.1    Wu, C.W.2    Lui, W.Y.3    Chang, T.J.4    Kao, H.L.5    Wu, L.H.6    King, K.L.7    Loong, C.C.8    Hsia, C.Y.9    Chi, C.W.10
  • 110
    • 0033035787 scopus 로고    scopus 로고
    • Secretion of acute-phase proteins before and after hepatocellular carcinoma resection
    • Hu, R. H., Lee, P. H., Yu, S. C. (1999) Secretion of acute-phase proteins before and after hepatocellular carcinoma resection. J. Formos. Med. Assoc. 98, 85-91.
    • (1999) J. Formos. Med. Assoc. , vol.98 , pp. 85-91
    • Hu, R.H.1    Lee, P.H.2    Yu, S.C.3
  • 111
    • 0031746396 scopus 로고    scopus 로고
    • Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells
    • Lee, Y., Park, U. S., Choi, I., Yoon, S. K., Park, Y. M., Lee, Y. I. (1998) Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells. Clin. Cancer Res. 4, 1711-1717.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1711-1717
    • Lee, Y.1    Park, U.S.2    Choi, I.3    Yoon, S.K.4    Park, Y.M.5    Lee, Y.I.6
  • 115
    • 3042575159 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor and interleukin-6 levels can distinguish patients with primary or metastatic liver tumors from those with benign liver lesions
    • Coskun, U., Bukan, N., Sancak, B., Gunel, N., Ozenirler, S., Unal, A., Yucel, A. (2004) Serum hepatocyte growth factor and interleukin-6 levels can distinguish patients with primary or metastatic liver tumors from those with benign liver lesions. Neoplasma 51, 209-213.
    • (2004) Neoplasma , vol.51 , pp. 209-213
    • Coskun, U.1    Bukan, N.2    Sancak, B.3    Gunel, N.4    Ozenirler, S.5    Unal, A.6    Yucel, A.7
  • 116
    • 0038147057 scopus 로고    scopus 로고
    • Association between interleukin 6 promoter variants and chronic hepatitis B progression
    • Park, B. L., Lee, H. S., Kim, Y. J., Kim, J. Y., Jung, J. H., Kim, L. H., Shin, H. D. (2003) Association between interleukin 6 promoter variants and chronic hepatitis B progression. Exp. Mol. Med. 35, 76-82.
    • (2003) Exp. Mol. Med. , vol.35 , pp. 76-82
    • Park, B.L.1    Lee, H.S.2    Kim, Y.J.3    Kim, J.Y.4    Jung, J.H.5    Kim, L.H.6    Shin, H.D.7
  • 117
    • 0031752720 scopus 로고    scopus 로고
    • Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia
    • Grasl-Kraupp, B., Rossmanith, W., Ruttkay-Nedecky, B., Mullauer, L., Kammerer, B., Bursch, W., Schulte-Hermann, R. (1998) Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology 28, 717-726.
    • (1998) Hepatology , vol.28 , pp. 717-726
    • Grasl-Kraupp, B.1    Rossmanith, W.2    Ruttkay-Nedecky, B.3    Mullauer, L.4    Kammerer, B.5    Bursch, W.6    Schulte-Hermann, R.7
  • 118
    • 0029018144 scopus 로고
    • Differential expression of transforming growth factor α, adhesions molecules and integrins in primary, metastatic liver tumors and in liver cirrhosis
    • Jaskiewicz, K., Chasen, M. R. (1995) Differential expression of transforming growth factor α, adhesions molecules and integrins in primary, metastatic liver tumors and in liver cirrhosis. Anticancer Res. 15, 559-562.
    • (1995) Anticancer Res. , vol.15 , pp. 559-562
    • Jaskiewicz, K.1    Chasen, M.R.2
  • 119
    • 0036152614 scopus 로고    scopus 로고
    • Transforming growth factor-β 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis
    • Yuen, M. F., Norris, S., Evans, L. W., Langley, P. G., Hughes, R. D. (2002) Transforming growth factor-β 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis. Scand. J. Gastroenterol. 37, 233-238.
    • (2002) Scand. J. Gastroenterol. , vol.37 , pp. 233-238
    • Yuen, M.F.1    Norris, S.2    Evans, L.W.3    Langley, P.G.4    Hughes, R.D.5
  • 121
    • 1542709590 scopus 로고    scopus 로고
    • Possible contribution of circulating transforming growth factor-β1 to immunity and prognosis in unresectable hepatocellular carcinoma
    • Okumoto, K., Hattori, E., Tamura, K., Kiso, S., Watanabe, H., Saito, K., Saito, T., Togashi, H., Kawata, S. (2004) Possible contribution of circulating transforming growth factor-β1 to immunity and prognosis in unresectable hepatocellular carcinoma. Liver Int. 24, 21-28.
    • (2004) Liver Int. , vol.24 , pp. 21-28
    • Okumoto, K.1    Hattori, E.2    Tamura, K.3    Kiso, S.4    Watanabe, H.5    Saito, K.6    Saito, T.7    Togashi, H.8    Kawata, S.9
  • 122
    • 0035116057 scopus 로고    scopus 로고
    • Alterations of the transforming growth factor-β signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats
    • Sasaki, Y., Tsujiuchi, T., Murata, N., Tsutsumi, M., Konishi, Y. (2001) Alterations of the transforming growth factor-β signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. Jpn. J. Cancer Res. 92, 16-22.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 16-22
    • Sasaki, Y.1    Tsujiuchi, T.2    Murata, N.3    Tsutsumi, M.4    Konishi, Y.5
  • 124
    • 0031048958 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials
    • Simonetti, R. G., Liberati, A., Angiolini, C., Pagliaro, L. (1997) Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann. Oncol. 8, 117-136.
    • (1997) Ann. Oncol. , vol.8 , pp. 117-136
    • Simonetti, R.G.1    Liberati, A.2    Angiolini, C.3    Pagliaro, L.4
  • 125
    • 3042547162 scopus 로고    scopus 로고
    • The impact of antiviral treatments on the course of chronic hepatitis C: An evidence-based approach
    • Camma, C., Di Bona, D., Craxi, A. (2004) The impact of antiviral treatments on the course of chronic hepatitis C: an evidence-based approach. Curr. Pharm. Des. 10, 2123-2130.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 2123-2130
    • Camma, C.1    Di Bona, D.2    Craxi, A.3
  • 126
    • 0035256554 scopus 로고    scopus 로고
    • Expression and function of interleukin-8 in human hepatocellular carcinoma
    • Akiba, J., Yano, H., Ogasawara, S., Higaki, K., Kojiro, M. (2001) Expression and function of interleukin-8 in human hepatocellular carcinoma. Int. J. Oncol. 18, 257-264.
    • (2001) Int. J. Oncol. , vol.18 , pp. 257-264
    • Akiba, J.1    Yano, H.2    Ogasawara, S.3    Higaki, K.4    Kojiro, M.5
  • 127
    • 12744254899 scopus 로고    scopus 로고
    • Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma
    • Hira, E., Ono, T., Dhar, D. K., El Assal, O. N., Hishikawa, Y., Yamanoi, A., Nagasue, N. (2005) Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma. Cancer 103, 588-598.
    • (2005) Cancer , vol.103 , pp. 588-598
    • Hira, E.1    Ono, T.2    Dhar, D.K.3    El Assal, O.N.4    Hishikawa, Y.5    Yamanoi, A.6    Nagasue, N.7
  • 128
    • 0037704549 scopus 로고    scopus 로고
    • Mechanism of interferon α on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice
    • Wang, L., Wu, W. Z., Sun, H. C., Wu, X. F., Qin, L. X., Liu, Y. K., Liu, K. D., Tang, Z. Y. (2003) Mechanism of interferon α on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice. J. Gastrointest. Surg. 7, 587-594.
    • (2003) J. Gastrointest. Surg. , vol.7 , pp. 587-594
    • Wang, L.1    Wu, W.Z.2    Sun, H.C.3    Wu, X.F.4    Qin, L.X.5    Liu, Y.K.6    Liu, K.D.7    Tang, Z.Y.8
  • 129
    • 30444461349 scopus 로고    scopus 로고
    • Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection
    • Asakawa, M., Kono, H., Amemiya, H., Matsuda, M., Suzuki, T., Maki, A., Fujii, H. (2006) Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection. Int. J. Cancer 118, 564-570.
    • (2006) Int. J. Cancer , vol.118 , pp. 564-570
    • Asakawa, M.1    Kono, H.2    Amemiya, H.3    Matsuda, M.4    Suzuki, T.5    Maki, A.6    Fujii, H.7
  • 130
    • 11144357986 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in Japanese patients with hepatitis C virus infection
    • Wang, Y., Kato, N., Hoshida, Y., Otsuka, M., Taniguchi, H., Moriyama, M., Shiina, S., Kawabe, T., Ito, Y. M., Omata, M. (2004) UDP- glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in Japanese patients with hepatitis C virus infection. Clin. Cancer Res. 10, 2441-2446.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2441-2446
    • Wang, Y.1    Kato, N.2    Hoshida, Y.3    Otsuka, M.4    Taniguchi, H.5    Moriyama, M.6    Shiina, S.7    Kawabe, T.8    Ito, Y.M.9    Omata, M.10
  • 132
    • 2342635289 scopus 로고    scopus 로고
    • Study of the effects of interferon a on several human hepatoma cell lines: Analysis of the signaling pathway of the cytokine and of its effects on apoptosis and cell proliferation
    • Legrand, A., Vadrot, N., Lardeux, B., Bringuier, A. F., Guillot, R., Feldmann, G. (2004) Study of the effects of interferon a on several human hepatoma cell lines: analysis of the signaling pathway of the cytokine and of its effects on apoptosis and cell proliferation. Liver Int. 24, 149-160.
    • (2004) Liver Int. , vol.24 , pp. 149-160
    • Legrand, A.1    Vadrot, N.2    Lardeux, B.3    Bringuier, A.F.4    Guillot, R.5    Feldmann, G.6
  • 133
    • 30444448237 scopus 로고    scopus 로고
    • Interferon-α/β upregulate IL-15 expression in vitro and in vivo: Analysis in human hepatocellular carcinoma cell lines and in chronic hepatitis C patients during interferon-α/β treatment
    • Yamaji, K., Nabeshima, S., Murata, M., Chong, Y., Furusyo, N., Ikematsu, H., Hayashi, J. (2006) Interferon-α/β upregulate IL-15 expression in vitro and in vivo: analysis in human hepatocellular carcinoma cell lines and in chronic hepatitis C patients during interferon-α/β treatment. Cancer Immunol. Immunother. 55, 394-403.
    • (2006) Cancer Immunol. Immunother. , vol.55 , pp. 394-403
    • Yamaji, K.1    Nabeshima, S.2    Murata, M.3    Chong, Y.4    Furusyo, N.5    Ikematsu, H.6    Hayashi, J.7
  • 135
    • 0026064193 scopus 로고
    • Effects of cytokines on in vitro growth of tumor-infiltrating lymphocytes obtained from human primary and metastatic liver tumors
    • Shimizu, Y., Iwatsuki, S., Herberman, R. B., Whiteside, T. L. (1991) Effects of cytokines on in vitro growth of tumor-infiltrating lymphocytes obtained from human primary and metastatic liver tumors. Cancer Immunol. Immunother. 32, 280-288.
    • (1991) Cancer Immunol. Immunother. , vol.32 , pp. 280-288
    • Shimizu, Y.1    Iwatsuki, S.2    Herberman, R.B.3    Whiteside, T.L.4
  • 137
    • 0030874596 scopus 로고    scopus 로고
    • Critical stages of tumor growth regulation in transgenic mice harboring a hepatocellular carcinoma revealed by distinct patterns of tumor necrosis factor-α and transforming growth factor-β mRNA production
    • Romieu, R., Lacabanne, V., Kayibanda, M., Antoine, B., Bennoun, M., Chouaib, S., Guillet, J. G., Viguier, M. (1997) Critical stages of tumor growth regulation in transgenic mice harboring a hepatocellular carcinoma revealed by distinct patterns of tumor necrosis factor-α and transforming growth factor-β mRNA production. Int. Immunol. 9, 1405-1413.
    • (1997) Int. Immunol. , vol.9 , pp. 1405-1413
    • Romieu, R.1    Lacabanne, V.2    Kayibanda, M.3    Antoine, B.4    Bennoun, M.5    Chouaib, S.6    Guillet, J.G.7    Viguier, M.8
  • 139
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva, S., Sun, R., Pan, H. N., Hong, F., Gao, B. (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39, 1332-1342.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 142
    • 2942534509 scopus 로고    scopus 로고
    • Activin a stimulates vascular endothelial growth factor gene transcription in human hepatocellular carcinoma cells
    • Wagner, K., Peters, M., Scholz, A., Benckert, C., Ruderisch, H. S., Wiedenmann, B., Rosewicz, S. (2004) Activin A stimulates vascular endothelial growth factor gene transcription in human hepatocellular carcinoma cells. Gastroenterology 126, 1828-1843.
    • (2004) Gastroenterology , vol.126 , pp. 1828-1843
    • Wagner, K.1    Peters, M.2    Scholz, A.3    Benckert, C.4    Ruderisch, H.S.5    Wiedenmann, B.6    Rosewicz, S.7
  • 143
    • 17044384183 scopus 로고    scopus 로고
    • Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma
    • Moran, D. M., Mayes, N., Koniaris, L. G., Cahill, P. A., McKillop, I. H. (2005) Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Liver Int. 25, 445-457.
    • (2005) Liver Int. , vol.25 , pp. 445-457
    • Moran, D.M.1    Mayes, N.2    Koniaris, L.G.3    Cahill, P.A.4    McKillop, I.H.5
  • 144
    • 0034870510 scopus 로고    scopus 로고
    • Interferon α and alcohol augment nuclear regulatory factor-κB activation in HepG2 cells, and interferon α increases pro-inflammatory cytokine production
    • Szabo, G., Catalano, D., Bellerose, G., Mandrekar, P. (2001) Interferon α and alcohol augment nuclear regulatory factor-κB activation in HepG2 cells, and interferon α increases pro-inflammatory cytokine production. Alcohol. Clin. Exp. Res. 25, 1188-1197.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1188-1197
    • Szabo, G.1    Catalano, D.2    Bellerose, G.3    Mandrekar, P.4
  • 146
    • 0346874205 scopus 로고    scopus 로고
    • Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model
    • Perlemuter, G., Letteron, P., Carnot, F., Zavala, F., Pessayre, D., Nalpas, B., Brechot, C. (2003) Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model. J. Hepatol. 39, 1020-1027.
    • (2003) J. Hepatol. , vol.39 , pp. 1020-1027
    • Perlemuter, G.1    Letteron, P.2    Carnot, F.3    Zavala, F.4    Pessayre, D.5    Nalpas, B.6    Brechot, C.7
  • 147
    • 13444280343 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces an anergic state characterized by decreased interleukin-2 production and perturbation of mitogen-activated protein kinase responses
    • Sundstrom, S., Ota, S., Dimberg, L. Y., Masucci, M. G., Bergqvist, A. (2005) Hepatitis C virus core protein induces an anergic state characterized by decreased interleukin-2 production and perturbation of mitogen-activated protein kinase responses. J. Virol. 79, 2230-2239.
    • (2005) J. Virol. , vol.79 , pp. 2230-2239
    • Sundstrom, S.1    Ota, S.2    Dimberg, L.Y.3    Masucci, M.G.4    Bergqvist, A.5
  • 149
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida, T., Hanada, T., Tokuhisa, T., Kosai, K., Sata, M., Kohara, M., Yoshimura, A. (2002) Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J. Exp. Med. 196, 641-653.
    • (2002) J. Exp. Med. , vol.196 , pp. 641-653
    • Yoshida, T.1    Hanada, T.2    Tokuhisa, T.3    Kosai, K.4    Sata, M.5    Kohara, M.6    Yoshimura, A.7
  • 150
    • 0032959637 scopus 로고    scopus 로고
    • Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL-6 through its basic-leucine zipper domain
    • Ohno, H., Kaneko, S., Lin, Y., Kobayashi, K., Murakami, S. (1999) Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL-6 through its basic-leucine zipper domain. J. Med. Virol. 58, 11-18.
    • (1999) J. Med. Virol. , vol.58 , pp. 11-18
    • Ohno, H.1    Kaneko, S.2    Lin, Y.3    Kobayashi, K.4    Murakami, S.5
  • 151
    • 14844307045 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
    • Yu, F. L., Liu, H. J., Lee, J. W., Liao, M. H., Shih, W. L. (2005) Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J. Hepatol. 42, 520-527.
    • (2005) J. Hepatol. , vol.42 , pp. 520-527
    • Yu, F.L.1    Liu, H.J.2    Lee, J.W.3    Liao, M.H.4    Shih, W.L.5
  • 152
    • 0034739918 scopus 로고    scopus 로고
    • Role of NF-κB and myc proteins in apoptosis induced by hepatitis B virus HBx protein
    • Su, F., Theodosis, C. N., Schneider, R. J. (2001) Role of NF-κB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J. Virol. 75, 215-225.
    • (2001) J. Virol. , vol.75 , pp. 215-225
    • Su, F.1    Theodosis, C.N.2    Schneider, R.J.3
  • 153
    • 0142211126 scopus 로고    scopus 로고
    • IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B
    • Lin, S. J., Shu, P. Y., Chang, C., Ng, A. K., Hu, C. P. (2003) IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B. J. Immunol. 171, 4708-4716.
    • (2003) J. Immunol. , vol.171 , pp. 4708-4716
    • Lin, S.J.1    Shu, P.Y.2    Chang, C.3    Ng, A.K.4    Hu, C.P.5
  • 154
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen, C. J., Yang, H. I., Su, J., Jen, C. L., You, S. L., Lu, S. N., Huang, G. T., Iloeje, U. H. (2006) Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295, 65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Lu, S.N.6    Huang, G.T.7    Iloeje, U.H.8
  • 155
    • 0036021364 scopus 로고    scopus 로고
    • Locoregional immunochemotherapy in hepatocellular carcinoma
    • Kountouras, J., Boura, P., Kouklakis, G. (2002) Locoregional immunochemotherapy in hepatocellular carcinoma. Hepatogastroenterology 49, 1109-1112.
    • (2002) Hepatogastroenterology , vol.49 , pp. 1109-1112
    • Kountouras, J.1    Boura, P.2    Kouklakis, G.3
  • 156
    • 28044456957 scopus 로고    scopus 로고
    • Dendritic cells pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma induce specific anti-tumor immune responses
    • Wang, X. H., Qin, Y., Hu, M. H., Xie, Y. (2005) Dendritic cells pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma induce specific anti-tumor immune responses. World J. Gastroenterol. 11, 5614-5620.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5614-5620
    • Wang, X.H.1    Qin, Y.2    Hu, M.H.3    Xie, Y.4
  • 159
    • 0033142430 scopus 로고    scopus 로고
    • Receptor-mediated interleukin-2 gene transfer into human hepatoma cells
    • Junbo, H., Li, Q., Zaide, W., Yunde, H. (1999) Receptor-mediated interleukin-2 gene transfer into human hepatoma cells. Int. J. Mol. Med. 3, 601-608.
    • (1999) Int. J. Mol. Med. , vol.3 , pp. 601-608
    • Junbo, H.1    Li, Q.2    Zaide, W.3    Yunde, H.4
  • 162
    • 0034779612 scopus 로고    scopus 로고
    • Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma
    • Wang, Z., Qiu, S. J., Ye, S. L., Tang, Z. Y., Xiao, X. (2001) Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma. Cancer Gene Ther. 8, 751-758.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 751-758
    • Wang, Z.1    Qiu, S.J.2    Ye, S.L.3    Tang, Z.Y.4    Xiao, X.5
  • 163
    • 0035432783 scopus 로고    scopus 로고
    • Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer
    • Zager, J. S., Delman, K. A., Malhotra, S., Ebright, M. I., Bennett, J. J., Kates, T., Halterman, M., Federoff, H., Fong, Y. (2001) Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol. Med. 7, 561-568.
    • (2001) Mol. Med. , vol.7 , pp. 561-568
    • Zager, J.S.1    Delman, K.A.2    Malhotra, S.3    Ebright, M.I.4    Bennett, J.J.5    Kates, T.6    Halterman, M.7    Federoff, H.8    Fong, Y.9
  • 164
    • 0032904436 scopus 로고    scopus 로고
    • The targeted expression of the human interleukin-2/interferon α2b fused gene in α-fetoprotein-expressing hepatocellular carcinoma cells
    • He, P., Tang, Z. Y., Liu, B. B., Ye, S. L., Liu, Y. K. (1999) The targeted expression of the human interleukin-2/interferon α2b fused gene in α-fetoprotein-expressing hepatocellular carcinoma cells. J. Cancer Res. Clin. Oncol. 125, 77-82.
    • (1999) J. Cancer Res. Clin. Oncol. , vol.125 , pp. 77-82
    • He, P.1    Tang, Z.Y.2    Liu, B.B.3    Ye, S.L.4    Liu, Y.K.5
  • 166
    • 17644390201 scopus 로고    scopus 로고
    • Liver-specific expression of interferon γ following adenoviral gene transfer controls hepatitis B virus replication in mice
    • Dumortier, J., Schonig, K., Oberwinkler, H., Low, R., Giese, T., Bujard, H., Schirmacher, P., Protzer, U. (2005) Liver-specific expression of interferon γ following adenoviral gene transfer controls hepatitis B virus replication in mice. Gene Ther. 12, 668-677.
    • (2005) Gene Ther. , vol.12 , pp. 668-677
    • Dumortier, J.1    Schonig, K.2    Oberwinkler, H.3    Low, R.4    Giese, T.5    Bujard, H.6    Schirmacher, P.7    Protzer, U.8
  • 167
    • 18344392456 scopus 로고    scopus 로고
    • Autologous fixed tumor vaccine: A formulation with cytokine- microparticles for protective immunity against recurrence of human hepatocellular carcinoma
    • Peng, B. G., Liu, S. Q., Kuang, M., He, Q., Totsuka, S., Huang, L., Huang, J., Lu, M. D., Liang, L. J., Leong, K. W., Ohno, T. (2002) Autologous fixed tumor vaccine: a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma. Jpn. J. Cancer Res. 93, 363-368.
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 363-368
    • Peng, B.G.1    Liu, S.Q.2    Kuang, M.3    He, Q.4    Totsuka, S.5    Huang, L.6    Huang, J.7    Lu, M.D.8    Liang, L.J.9    Leong, K.W.10    Ohno, T.11
  • 168
    • 0037080116 scopus 로고    scopus 로고
    • Inducing oral immune regulation of hepatitis B virus envelope proteins suppresses the growth of hepatocellular carcinoma in mice
    • Gotsman, I., Alper, R., Klein, A., Rabbani, E., Engelhardt, D., Ilan, Y. (2002) Inducing oral immune regulation of hepatitis B virus envelope proteins suppresses the growth of hepatocellular carcinoma in mice. Cancer 94, 406-414.
    • (2002) Cancer , vol.94 , pp. 406-414
    • Gotsman, I.1    Alper, R.2    Klein, A.3    Rabbani, E.4    Engelhardt, D.5    Ilan, Y.6
  • 169
    • 11144298762 scopus 로고    scopus 로고
    • Anti-inflammatory and antiviral effects of Glossogyne tenuifolia
    • Wu, M. J., Weng, C. Y., Ding, H. Y., Wu, P. J. (2005) Anti-inflammatory and antiviral effects of Glossogyne tenuifolia. Life Sci. 76, 1135-1146.
    • (2005) Life Sci. , vol.76 , pp. 1135-1146
    • Wu, M.J.1    Weng, C.Y.2    Ding, H.Y.3    Wu, P.J.4
  • 170
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumor stroma in cancer
    • Mueller, M. M., Fusenig, N. E. (2004) Friends or foes - bipolar effects of the tumor stroma in cancer. Nat. Rev. Cancer 4, 839-849.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 171
    • 0347123433 scopus 로고    scopus 로고
    • Tumor-educated macrophages promote tumor progression and metastasis
    • Pollard, J. W. (2004) Tumor-educated macrophages promote tumor progression and metastasis. Nat. Rev. Cancer 4, 71-78.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 172
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu, A., Forgues, M., Ye, Q. H., He, P., Zanetti, K. A., Kammula, U. S., Chen, Y., Qin, L. X., Tang, Z. Y., Wang, X. W. (2006) Prediction of venous metastases, recurrence and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10, 99-111.
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    He, P.4    Zanetti, K.A.5    Kammula, U.S.6    Chen, Y.7    Qin, L.X.8    Tang, Z.Y.9    Wang, X.W.10
  • 173
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani, A., Sozzani, S., Locati, M., Allavena, P., Sica, A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555.
    • (2002) Trends Immunol. , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 174
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • De Visser, K. E., Korets, L. V., Coussens, L. M. (2005) De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7, 411-423.
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.