Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)

Seminars in Cancer Biology

Volumn 10, Issue 3, 2000, Pages 211-231

  Bréchot, Christian ^a   Gozuacik, Devrim ^a   Murakami, Yoshiki ^a   Paterlini Bréchot, Patrizia ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; RNA POLYMERASE; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2;

ASIA; CELL DIFFERENTIATION; CELL HETEROGENEITY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; EUROPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HEREDITY; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; REVIEW; UNITED STATES;

EID: 0033860678     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0321     Document Type: Article

References (232)

1. Relationship between hepatocellular carcinoma and cirrhosis
2. The role of hepatitis B virus (HBV) in the development of hepatocellular carcinoma
3. Hepatitis B virus (HBV) and hepatocellular carcinoma. HBV DNA status and its implications
4. Molecular mechanisms of hepatitis B and C viruses related liver carcinogenesis
5. Hepatocellular carcinoma without cirrhosis in the West: Epidemiological factors and histopathology of the non-tumorous liver. Groupe d'etude et de traitement du carcinome hepatocellulaire
6. Control of liver growth
7. Liver regeneration
8. Clonal analysis of macronodules in cirrhosis
9. Hepatitis B virus transgenic mice: Insights into the virus and the disease
10. Hepatitis B virus transgenic mouse model of chronic liver disease
11. Hepatic pre-neoplasia in hepatitis B virus transgenic mice
12. Immune pathogenesis of hepatocellular carcinoma
13. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
14. The role of determined stem-cells in the cellular lineage of hepatocellular carcinoma
15. The hepatitis B virus
16. The molecular biology of the hepatitis B viruses
17. Hepatocellular carcinoma and hepatitis B virus infection: Molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes
18. Common evolutionary origin of hepatitis B virus and retroviruses
19. Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA
20. Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation
21. Chromosome 17 : 7 translocation is associated with hepatitis B virus DNA integration in human hepatocellular carcinoma DNA
22. The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma
23. Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma
24. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas
25. Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma
26. State of hepatitis B virus DNA in hepatocytes of patients with HbsAg positive and HbsAg negative liver diseases
27. Detection of hepatitis B virus DNA in liver and serum: A direct appraisal of the chronic carrier state
28. Analysis of liver disease, nuclear HBsAg, viral replication, and hepatitis B virus DNA, in liver and serum of HBeAg Vs. anti-Hbe positive carriers of hepatitis B virus
29. Hepatitis B viral DNA in liver and serum of asymptomatic carriers
30. Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma
31. Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children
32. Clonal growth of hepatitis B virus integrated hepatocytes in cirrhotic liver nodules
33. Sequences of hepatitis B virus DNA in the serum and liver of patients with acute benign and fulminant hepatitis
34. Hepatitis B virus DNA in Dane particules: Evidence for the presence of replicative intermediates
35. Interrupted replication of hepatitis B virus in liver tissue of HBsAg carriers with hepatocellular carcinoma
36. Liver/kidney microsome antibody type 1 and hepatitis C virus infection
37. Novel forms of woodchuck hepatitis virus DNA isolated from chronically infected woodchuck liver nuclei
38. Detection of HBV DNA in mononuclear blood cells
39. Hepatitis B virus DNA in mononuclear blood cells
40. Hepatitis B virus DNA sequences in lymphoid cells for patients with AIDS and AIDS-related complex
41. Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus
42. Detection and sequence analysis of hepatitis B virus integration in peripheral blood mononuclear cells
43. Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients
44. Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus
45. Presence of HBV DNA in spermatozoa-A possible vertical transmission of HBV via the germ line
46. Detection of hepatitis B viral RNAs in human liver tissues by in situ hybridization
47. Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer
48. Inhibition of hepatitis B virus surface antigen gene expression in carcinogen-induced liver tumors from transgenic mice
49. Acellular model of the role of hepatitis virus in the pathogenesis of primary hepatocellualr carcinoma
50. Detection of hepatitis B virus DNA in hepatocellular carcinoma
51. Replication of hepatitis B virus in a hepatocellular carcinoma
52. Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal
53. Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas
54. Analysis of the p53 gene in European hepatocellular carcinomas and hepatoblastomas
55. Geographic variation of p53 mutational profile in nonmalignant human liver
56. Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line
57. Deletions in human chromosome arms 11p and 13p in primary hepatocellular carcinomas
58. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China
59. Aberrations of tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
60. Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma
61. Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas
62. Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas
63. Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma
64. Coamplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma
65. Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators
66. Genetic heterogeneity of hepatocellular carcinoma
67. Cyclin A expression in human hematological malignancies: A new marker of cell proliferation
68. Truncated hepatitis B virus RNA in human hepatocellular carcinoma: Its representation in patients with advancing age
69. Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinoma
70. Expression of mutated hepatitis B virus X gene in human hepatocellular carcinomas
71. Hepatic expression of the woodchuck Hepatitis Virus X-antigen during acute and chronic infection and detection of a woodchuck hepatitis X-antigen antibody response
72. Hepadnaviral X protein: Review of recent progress
73. Hepatitis B virus X protein: Structure, function and biology
74. Src kinases involved in hepatitis B virus replication
75. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks
76. Woodchuck hepatitis virus X protein is required for viral infection in vivo
77. The hepatitis B virus X protein transactivates viral core gene expression in vivo
78. Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fribroblasts
79. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls
80. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA
81. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells
82. HBx gene of hepatitis B virus induces liver cancer in transgenic mice
83. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein
84. Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice
85. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
86. The hepatitis B virus X gene potentiates c-myc induced liver oncogenesis in transgenic mice
87. The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes
88. Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator
89. Hepatitis B virus X-gene product: A promiscuous transcriptional activator
90. Human RPB5 a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
91. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein
92. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
93. Endothelial cell transplantation
94. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
95. HBx protein of hepatitis B virus activates Jak1-STAT signaling
96. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
97. Cytosol is the prime compartment of hepatitis B virus where it colocalizes with the proteasome
98. Hepatitis B virus pX activates NF-kB dependent transcription through a Raf-independent pathway
99. Direct association and nuclear import of the hepatitis B virus X protein with the NF-χB inhibitor IχBα
100. HBx Protein of Hepatitis B Virus Interacts with the C-Terminal Portion of a Novel Human Proteasome Alpha-Subunit
101. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
102. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein
103. Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells
104. Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants
105. The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis
106. Identification of a protein isolated from senescent human cells that binds to hepatitis B virus X antigen
107. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
108. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation
109. Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis
110. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells
111. The possible role of HBV infection in molecular mechanisms of HCV-related hepatocarcinogenesis in Japan
112. Analysis of tumorigenicity of the X gene of hepatitis B virus in nontransformed hepatocyte cell line and the effect of cotransfection with a murine p53 mutant equivalent to human codon 249
113. X-gene product of hepatitis B virus induces apoptosis in liver cells
114. Abrogation of cell cycle arrest and apoptosis induced by hepatitis B virus x protein by mutations present in hepatocellular carcinoma tissues
115. The hepatitis B virus X gene induces p53-mediated programmed cell death
116. p-53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro
117. Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system
118. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor a
119. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
120. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
121. Expression of fas ligand in human hepatoma cell lines: Role of hepatitis-B virus X (HBX) in induction of Fas ligand
122. The hepatitis B virus HBx protein inhibits caspase 3 activity
123. Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines
124. Tumour suppressive properties of the adenovirus 5 E1A oncogene
125. Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirusoncogene expression and acute growth inhibition of cervical carcinoma cell lines
126. Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis
127. Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication
128. Exogenous nucleosides promote the completion of MoMLV DNA synthesis in G0-arrested Balb c/3T3 fibroblasts
129. Deletion mutants of the hepatitis B virus X gene in human hepatocellular carcinoma
130. The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines
131. Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation
132. ER-localization and functionnal expression of the HBV transactivator MHBs'
133. The hepatitis B virus PreS2/ST Transactivation utilizes AP-1 and transcription factors for transactivation
134. Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro
135. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo
136. Inhibition of tje expression of Interferon inducible MxA protein by the hepatitis B virus capsid protein
137. In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA
138. Hepatitis B viruses and hepatocellular carcinoma
139. Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion
140. Nucleotide sequence of the woodchuck N-myc gene (WN-myc1)
141. Frequent activation of N-myc genes by hepatdnavirus insertion in woodchuck liver tumors
142. Hepatitis B virus DNA integration in a sequence homologous to v-erbA and steroid receptor genes in a hepatocellular carcinoma
143. Hepatitis B virus as an insertional mutagen in a human hepatocellular carcinoma
144. A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro
145. The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
146. The PML-RAR-alpha fusion mRNA generated by the t(15,17) translocation in acute promyelocytic leukaemia encodes a functionally altered retinoic acid receptor
147. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
148. Cyclin A: Function and expression during cell proliferation
149. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
150. Modification of cyclin A expression by hepatitis b virus DNA integration in a hepatocellular carcinoma
151. Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon hepatitis B virus genome insertion
152. HCV-associated liver cancer without cirrhosis
153. Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAG negative patients: A study of a low endemic area
154. Activation of cellular genes by hepatitis B virus in hepatocellular carcinogenesis
155. Enzymatic properties of over-expressed HBV-mevalonate fusion proteins and mevalonate kinase proteins in the human hepatoma cell line PLC/PRF/5
156. New SERCA1 transcripts are revealed by hepatitis B virus-revealed by hepatitis B virus-related SERCA1 gene mutagenesis in a human hepatocellular carcinoma and control cell variability
157. A t (3;8) Chromosomal translocation associated with Hepatitis B virus integration involves the carboxypeptidase N locus
158. Hepatitis B virus DNA integration and expression of an Erb B-like gene in human hepatocellular carcinoma
159. Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair
160. Evidence for long-range oncogene activation by hepadnavirus insertion
161. A novel PCR technique using Alu specific primers to identify unknown flanking sequences from the human genome
162. Leukemia disease genes: Large-scale cloning and pathway predictions
163. An association between viral genes and human oncogenic alterations: The adenovirus E1A induces the Ewing tumor fusion transcript EWS-FLI1
164. Sequence of a replication competent hepatitis B virus genome with a preX open reading frame
165. Deletion of integrated hepatitis B virus genome and cellular flanking sequences in hepatocellular carcinoma cells in BALB/c mice
166. Hepatitis B virus preC mutants in human hepatocellular carcinoma tissues
167. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers
168. Cytokines in viral hepatitis
169. Viral clearance without destruction of infected cells during acute HBV infection
170. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
171. Cytokine inhibition of the hepatitis B virus core promoter
172. Negative regulation of hepatitis B virus gene expression and replication by oxidative stress
173. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma
174. Hepatitis B virus persistence after recovery from acute viral hepatitis
175. The hepatitis B virus persists for decades after patients recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
176. Hepatitis B virus DNA in patients with chronic liver disease and negative test for hepatitis B surface antigen
177. Transmission of hepatitis B from hepatitis B seronegative subjects
178. 'Occult' hepatitis B virus as source of infection in liver transplant recipients
179. Hepatitis B virus DNA in peripheral-blood mononuclear cells in chronic hepatitis B after HBsAg clearance
180. Genetic variations of the Hepatitis B virus and their clinical relevance
181. Hepatitis B virus infection without immunological markers after open-heart surgery
182. Complete nucleotide sequences and the characteristics of two hepatitis B virus mutants causing serologically negative acute or chronic hepatitis
183. Sequence analysis of hepatitis B virus DNA in immunologically negative infection
184. Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient
185. Detection of hepatitis B virus DNA in tissues of hepatocellular carcinomas related to hepatitis C virus which are negative for hepatitis B virus surface antigen
186. Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus
187. Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues
188. Detection of hepatitis B virus X-region DNA in liver tissue from patients with hepatitis C virus-associated cirrhosis who subsequently developed hepatocellular carcinoma
189. Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: Clinical and virological significance
190. Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients
191. Does dual infection by hepatitis B and C viruses play an important role in the pathogenesis of hepatocellular carcinoma in Japan?
192. Direct detection of hepatitis B virus gene integrated in the Alexander cell using fluorescence in situ polymerase chain reaction
193. Detection of hepatitis B virus DNA by polymerase chain reaction in HBsAg negative Senegalese patients suffering from cirrhosis or primary liver cancer
194. Polymerase chain reaction for detection of hepatitis B virus DNA in HBsAg seronegative patients with hepatocellular carcinoma from Mozambique
195. Clearance of HBsAg in seven patients with chronic hepatitis B
196. Viral genetic variation: Hepatitis B virus as a clinical example
197. Effects of ethanol on hepatitis B virus PRE/S/S genes expression in the human hepatocellular carcinoma derived HepG2 cell line
198. Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections
199. Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus
200. The oncogenic potential of herpes simplex virus: Evidence for a 'hit and run' mechanism
201. Human papillomavirus type 6b DNA is required for initiation but not maintenance of transformation of C127 mouse cells
202. 'Hit and run' transformation of mouse C127 cells by bovine papillomavirus type 4: The viral DNA is required for the initiation but not for maintenance of the transformed phenotype
203. Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chiken hepatoma cells
204. Hepatocellular carcinoma
205. Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance
206. Hepatitis C viremia and anti-HCV antibodies in alcoholics
207. Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease
208. The role of hepatitis viruses in the genesis of hepatocellular carcinoma in alcoholic cirrhotics
209. Hepatitis C virus antibodies in chronic alcoholic patients: Association with severity of liver injury
210. Les marqueurs du virus B chez les alcooliques chroniques
211. Hepatitis B virus multiplication in the absence of usual serological markers - A study of 146 alcoholics
212. Independent risk factors for hepatocellular carcinoma in French drinkers
213. Importance of markers of hepatitis B virus in alcoholic liver disease
214. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease
215. Effect of interferon-a on progression of cirrhosis to hepatocellular carcinoma: A retrospective cohort study
216. Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: Results of a European concerted action
217. Clinical and virological profiles in patients with multiple hepatitis virus infections
218. Long-term follow-up of hepatitis B virus and hepatitis C virus replicative levels in chronic hepatitis patients coinfected with both viruses
219. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
220. A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma