The nonstructural NS5a protein of hepatitis c virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesis

Journal of Biomedical Science

Volumn 9, Issue 3, 2002, Pages 187-197

  Reyes, Gregory R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hepatitis C virus; Interferon sensitivity determining region; Interferon ; NS5A; PKR; Viral pathogenesis

Indexed keywords

ALPHA INTERFERON; CALCIUM; CELL PROTEIN; CYCLINE; DOUBLE STRANDED RNA; GENE PRODUCT; GROWTH FACTOR RECEPTOR; INTERFERON; INTERLEUKIN 8; NONSTRUCTURAL PROTEIN 5A; PROTEIN; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; VIRUS PROTEIN; GRB2 PROTEIN, HUMAN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; PROTEIN KINASE R; RNA DIRECTED RNA POLYMERASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; CELL CYCLE; CELL NUCLEUS; CYTOPLASM; DOSE RESPONSE; DRUG EFFICACY; ENDOPLASMIC RETICULUM; GROWTH REGULATION; HEPATITIS C; HEPATITIS C VIRUS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; LIVER CARCINOGENESIS; MOLECULAR WEIGHT; NONHUMAN; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REPLICON; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS; VIRUS REPLICATION; CHEMISTRY; DRUG EFFECT; METABOLISM; PATHOGENICITY; PHYSIOLOGY; VIROLOGY;

APOPTOSIS; CALCIUM; EIF-2 KINASE; HEPACIVIRUS; HEPATITIS C; HUMAN; INTERFERON-ALPHA; INTERLEUKIN-8; PROTEINS; RNA REPLICASE; TRANSCRIPTION FACTORS; VIRAL NONSTRUCTURAL PROTEINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GRB2 ADAPTOR PROTEIN; HUMANS;

HEPATITIS C VIRUS;

EID: 0036017204     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000059419     Document Type: Review

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