Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages

Virology

Volumn 279, Issue 1, 2001, Pages 271-279

  Lee, Chu Hee ^a   Choi, Yo Han ^a   Yang, Se Hwan ^a   Lee, Chang Woo ^a   Ha, Sang Jun ^a   Sung, Young Chul ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN P40; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CHRONIC LIVER DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MIXED LYMPHOCYTE REACTION; MONOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; VIRUS CELL INTERACTION; VIRUS RESISTANCE;

HEPATITIS C VIRUS;

EID: 0035916008     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0694     Document Type: Article

References (48)

1. HCV core protein interacts with 14-3-3 protein and activates the kinase Raf-1
2. The role of nitric oxide in innate immunity
3. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients
4. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene
5. The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases
6. Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus
7. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro
8. The scientific challenge of hepatitis C
9. Inhibition of phorbol ester-induced neutrophil chemiluminescence by FeLV
10. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
11. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
12. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: Comparison of activating cytokines and evidence for independent production
13. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
14. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
15. Active hepatitis C virus infection in bone marrow and peripheral blood mononuclear cells from patients with mixed cryoglobulinaemia
16. Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells
17. Low stimulatory capacity of lymphoid dendritic cells expressing hepatitic C virus genes
18. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
19. Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K
20. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals
21. Mechanism of suppression of cell-mediated immunity by measles virus
22. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1
23. Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence
24. Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication
25. Deficient secretion of Th 1 cytokines in patients with chronic hepatitis C
26. The Bel1 protein of human foamy virus contains one positive and two negative control regions which regulate a distinct activation domain of 30 amino acids
27. Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells
28. In vivo tropism of hepatitis C virus genomic sequences in hematopoietic cells: Influence of viral load, viral genotype, and cell phenotype
29. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
30. Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
31. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the antiviral cell-mediated immune response
32. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
33. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
34. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein
35. Transcriptional repression of p53 promoter by hepatitis C virus core protein
36. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells
37. Inhibition of lymphoproliferation and protein kinase C by synthetic peptides with sequence identity to the transmembrane and Q proteins of visna virus
38. Different cytokine profiles of peripheral blood mononuclear cells from patients with persistent and self-limited hepatitis C virus infection
39. Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation
40. The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon
41. Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication
42. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
43. Interleukin 12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
44. Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
45. Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells
46. Cytokine response to hepatitis C virus core peptides in patients with chronic hepatitis C infection and healthy anti-HCV seropositives
47. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
48. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis