Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA Level

Journal of the American Medical Association

Volumn 295, Issue 1, 2006, Pages 65-73

  Chen, Chien Jen ^a   Yang, Hwai I ^a   Su, Jun ^b   Jen, Chin Lan ^a   You, San Lin ^a   Lu, Sheng Nan ^c   Huang, Guan Tarn ^a   Iloeje, Uchenna H ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b BRISTOL MYERS SQUIBB   (United States)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; VIRUS DNA;

ADULT; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CANCER REGISTRY; CANCER RISK; CANCER SCREENING; CIGARETTE SMOKING; CLINICAL EXAMINATION; COHORT ANALYSIS; COMMUNITY CARE; CONTROLLED STUDY; DATA ANALYSIS; EVALUATION; FEMALE; FOLLOW UP; GENETIC LINKAGE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX RATIO; TAIWAN;

ADULT; ALANINE TRANSAMINASE; CARCINOMA, HEPATOCELLULAR; DNA, VIRAL; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INCIDENCE; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; TAIWAN;

EID: 29944436855     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.295.1.65     Document Type: Article

References (22)

1. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337:1733-1745.
2. Chen CJ, Wang LY, Yu MW.Epidemiology of hepatitis B virus infection in the Asia-Pacific region. J Gastroenterol Hepatol. 2000;15(suppl):E3-E6.
3. Beasley RP. Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer. 1988;61:1942-1956.
4. McMahon BJ. Hepatocellular carcinoma and viral hepatitis. In: Wilson RA, ed. Viral Hepatitis: Diagnosis, Treatment, Prevention. New York, NY: Marcel Deckker; 1997:315-330.
5. Chen CJ, Chen DS. Interaction of hepatitis B virus, chemical carcinogen, and genetic susceptibility: multistage hepatocarcinogenesis with multifactorial etiology. Hepatology. 2002;36:1046-1049.
6. Chen CJ, Yu MW, Liaw YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol. 1997;12:S294-S308.
7. Yang HI, Lu SN, Liaw YF, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med. 2002;347:168-174.
8. You SL, Yang HI, Chen CJ. Seropositivity of hepatitis B e antigen and hepatocellular carcinoma. Ann Med. 2004;36:215-224.
9. Chen CJ, Yang HI, You SL. Hepatitis B e antigen and the risk of hepatocellular carcinoma [reply]. N Engl J Med. 2002;347:1722.
10. Geier A, Dietrich CG, Gartung C. Antiviral therapy in HBe-Ag-positive hepatitis B with normal aminotransferase levels. Hepatology. 2003;37:712-713.
11. Liaw YF, Leung N, Guan R, Lau GK, Merican I. Asian-Pacific consensus statement on the management of chronic hepatitis B: an update. J Gastroenterol Hepatol. 2003;18:239-245.
12. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2001;34:1225-1241.
13. Lok ASF, Dietrich CG, Gartung C. Antiviral therapy in HBe-Ag-positive hepatitis B with normal aminotransferase levels [reply]. Hepatology. 2003;37:713.
14. Mommeja-Marin H, Mondou E, Blum MR, Rousseau F. Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: analysis and review of the literature. Hepatology. 2003;37:1309-1319.
15. Alberti A. Can serum HBV-DNA be used as a primary end point to assess efficacy of new treatments for chronic hepatitis B? Hepatology. 2003;38:18-20.
16. Pena E, Rohatgi VK. Small sample and efficiency results for the Nelson-Aalen estimator. J Stat Plann Inference. 1993;37:192-202.
17. Breslow N, Crowley J. A large sample study of the life table and product limit estimates under random censorship. Ann Stat. 1974;2:437-453.
18. Aalen O. Nonparametric inference for a family of counting processes. Ann Stat. 1978;6:701-726.
19. Chang MH, Hsu HY, Hsu HC, Ni YH, Chen JS, Chen DS. The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age. Hepatology. 1995;22:1387-1392.
20. Chu CJ, Hussain M, Lok AS. Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection. Hepatology. 2002;36:1408-1415.
21. Lee PI, Chang MH, Lee CY, et al. Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children. Hepatology. 1990;12:657-660.
22. Yu MW, Yeh SH, Chen PJ, et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst. 2005;97:265-272.