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Volumn 79, Issue 4, 2005, Pages 2230-2239

Hepatitis C virus core protein induces an anergic state characterized by decreased interleukin-2 production and perturbation of mitogen-activated protein kinase responses

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CORE PROTEIN; CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 13444280343     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.4.2230-2239.2005     Document Type: Article
Times cited : (26)

References (87)
  • 3
    • 0025251136 scopus 로고
    • Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain delta: Differences between v- and c-Jun
    • Baichwal, V. R., and R. Tjian. 1990. Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain delta: differences between v- and c-Jun. Cell 63:815-825.
    • (1990) Cell , vol.63 , pp. 815-825
    • Baichwal, V.R.1    Tjian, R.2
  • 4
    • 0031925283 scopus 로고    scopus 로고
    • Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles
    • Bassett, S. E., K. M. Brasky, and R. E. Lanford. 1998. Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles. J. Virol. 72:2589-2599.
    • (1998) J. Virol. , vol.72 , pp. 2589-2599
    • Bassett, S.E.1    Brasky, K.M.2    Lanford, R.E.3
  • 5
    • 0035172909 scopus 로고    scopus 로고
    • Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein
    • Bergqvist, A., and C. M. Rice. 2001. Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein. J. Virol. 75:772-781.
    • (2001) J. Virol. , vol.75 , pp. 772-781
    • Bergqvist, A.1    Rice, C.M.2
  • 7
    • 0028114164 scopus 로고
    • Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin
    • Bjoro, K., S. S. Froland, Z. Yun, H. H. Samdal, and T. Haaland. 1994. Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin. N. Engl. J. Med. 331:1607-1611.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1607-1611
    • Bjoro, K.1    Froland, S.S.2    Yun, Z.3    Samdal, H.H.4    Haaland, T.5
  • 8
    • 0028015647 scopus 로고
    • Detection and distribution of hepatitis C-specific antigens in naturally infected liver
    • Blight, K. J., R. R. Lesniewski, J. T. LaBrooy, and E. J. Gowans. 1994. Detection and distribution of hepatitis C-specific antigens in naturally infected liver. Hepatology 20:553-557.
    • (1994) Hepatology , vol.20 , pp. 553-557
    • Blight, K.J.1    Lesniewski, R.R.2    LaBrooy, J.T.3    Gowans, E.J.4
  • 10
    • 0031961944 scopus 로고    scopus 로고
    • Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2
    • Butscher, W. G., C. Powers, M. Olive, C. Vinson, and K. Gardner. 1998. Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2. J. Biol. Chem. 273:552-560.
    • (1998) J. Biol. Chem. , vol.273 , pp. 552-560
    • Butscher, W.G.1    Powers, C.2    Olive, M.3    Vinson, C.4    Gardner, K.5
  • 13
    • 0034283665 scopus 로고    scopus 로고
    • JNK1 is required for T cell-mediated immunity against Leishmania major infection
    • Constant, S. L., C. Dong, D. D. Yang, M. Wysk, R. J. Davis, and R. A. Flavell. 2000. JNK1 is required for T cell-mediated immunity against Leishmania major infection. J. Immunol. 165:2671-2676.
    • (2000) J. Immunol. , vol.165 , pp. 2671-2676
    • Constant, S.L.1    Dong, C.2    Yang, D.D.3    Wysk, M.4    Davis, R.J.5    Flavell, R.A.6
  • 15
    • 0028787184 scopus 로고
    • In vitro infection of peripheral blood mononuclear cells by hepatitis C virus
    • Cribier, B., C. Schmitt, A. Bingen, A. Kirn, and F. Keller. 1995. In vitro infection of peripheral blood mononuclear cells by hepatitis C virus. J. Gen. Virol. 76:2485-2491.
    • (1995) J. Gen. Virol. , vol.76 , pp. 2485-2491
    • Cribier, B.1    Schmitt, C.2    Bingen, A.3    Kirn, A.4    Keller, F.5
  • 17
    • 0032080849 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy
    • DeSilva, D. R., E. A. Jones, M. F. Favata, B. D. Jaffee, R. L. Magolda, J. M. Trzaskos, and P. A. Scherle. 1998. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. 160:4175-4181.
    • (1998) J. Immunol. , vol.160 , pp. 4175-4181
    • DeSilva, D.R.1    Jones, E.A.2    Favata, M.F.3    Jaffee, B.D.4    Magolda, R.L.5    Trzaskos, J.M.6    Scherle, P.A.7
  • 18
    • 0031572154 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells
    • DeSilva, D. R., E. A. Jones, W. S. Feeser, E. J. Manos, and P. A. Scherle. 1997. The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells. Cell. Immunol. 180:116-123.
    • (1997) Cell. Immunol. , vol.180 , pp. 116-123
    • DeSilva, D.R.1    Jones, E.A.2    Feeser, W.S.3    Manos, E.J.4    Scherle, P.A.5
  • 19
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder, H. M., R. Zachoval, R. M. Hoffmann, E. A. Wierenga, T. Santantonio, M. C. Jung, D. Eichenlaub, and G. R. Pape. 1995. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346:1006-1007.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6    Eichenlaub, D.7    Pape, G.R.8
  • 22
    • 0345447666 scopus 로고    scopus 로고
    • IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
    • D'Souza, W. N., and L. Lefrancois. 2003. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171:5727-5735.
    • (2003) J. Immunol. , vol.171 , pp. 5727-5735
    • D'Souza, W.N.1    Lefrancois, L.2
  • 23
    • 0032904882 scopus 로고    scopus 로고
    • In vitro human Th-cell responses to a recombinant hepatitis C virus antigen: Failure in IL-2 production despite proliferation
    • Eckels, D. D., N. Tabatabail, T.-H. Bian, H. Wang, S. S. Muheisen, C. M. Rice, K. Yoshizawa, and J. U. Gill. 1999. In vitro human Th-cell responses to a recombinant hepatitis C virus antigen: failure in IL-2 production despite proliferation. Hum. Immunol. 60:187-199.
    • (1999) Hum. Immunol. , vol.60 , pp. 187-199
    • Eckels, D.D.1    Tabatabail, N.2    Bian, T.-H.3    Wang, H.4    Muheisen, S.S.5    Rice, C.M.6    Yoshizawa, K.7    Gill, J.U.8
  • 24
    • 0036058267 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line
    • Erhardt, A., M. Hassan, T. Heintges, and D. Haussinger. 2002. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology 292:272-284.
    • (2002) Virology , vol.292 , pp. 272-284
    • Erhardt, A.1    Hassan, M.2    Heintges, T.3    Haussinger, D.4
  • 25
    • 0029991920 scopus 로고    scopus 로고
    • Blocked Ras activation in anergic CD4+ T cells
    • Fields, P. E., T. F. Gajewski, and F. W. Fitch. 1996. Blocked Ras activation in anergic CD4+ T cells. Science 271:1276-1278.
    • (1996) Science , vol.271 , pp. 1276-1278
    • Fields, P.E.1    Gajewski, T.F.2    Fitch, F.W.3
  • 26
    • 0026061865 scopus 로고
    • Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
    • Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313-316.
    • (1991) Science , vol.251 , pp. 313-316
    • Fraser, J.D.1    Irving, B.A.2    Crabtree, G.R.3    Weiss, A.4
  • 28
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale, M. J., Jr, M. J. Korth, N. M. Tang, S. L. Tan, D. A. Hopkins, T. E. Dever, S. J. Polyak, D. R. Gretch, and M. G. Katze. 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230:217-227.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale Jr., M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 30
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
    • Giambartolomei, S., F. Covone, M. Levrero, and C. Balsano. 2001. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene 20:2606-2610.
    • (2001) Oncogene , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3    Balsano, C.4
  • 31
    • 0029905354 scopus 로고    scopus 로고
    • Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase
    • Groom, L. A., A. A. Sneddon, D. R. Alessi, S. Dowd, and S. M. Keyse. 1996. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15:3621-3632.
    • (1996) EMBO J. , vol.15 , pp. 3621-3632
    • Groom, L.A.1    Sneddon, A.A.2    Alessi, D.R.3    Dowd, S.4    Keyse, S.M.5
  • 32
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • Groux, H., M. Bigler, J. E. de Vries, and M. G. Roncarolo. 1996. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med. 184:19-29.
    • (1996) J. Exp. Med. , vol.184 , pp. 19-29
    • Groux, H.1    Bigler, M.2    De Vries, J.E.3    Roncarolo, M.G.4
  • 34
    • 0033755010 scopus 로고    scopus 로고
    • Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha
    • Hayashi, J., H. Aoki, K. Kajino, M. Moriyama, Y. Arakawa, and O. Hino. 2000. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology 32:958-961.
    • (2000) Hepatology , vol.32 , pp. 958-961
    • Hayashi, J.1    Aoki, H.2    Kajino, K.3    Moriyama, M.4    Arakawa, Y.5    Hino, O.6
  • 35
    • 0000361013 scopus 로고    scopus 로고
    • Hepatitis C viruses
    • B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Lippincott-Raven Publishers, Philadelphia, Pa.
    • Houghton, M. 1996. Hepatitis C viruses, p. 1035-1058. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed., vol. 1. Lippincott-Raven Publishers, Philadelphia, Pa.
    • (1996) Fields Virology, 3rd Ed. , vol.1 , pp. 1035-1058
    • Houghton, M.1
  • 36
    • 0038102952 scopus 로고    scopus 로고
    • Combined interferon alpha2b and cyclosporin a in the treatment of chronic hepatitis C: Controlled trial
    • Inoue, K., K. Sekiyama, M. Yamada, T. Watanabe, H. Yasuda, and M. Yoshiba. 2003. Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial. J. Gastroenterol. 38:567-572.
    • (2003) J. Gastroenterol. , vol.38 , pp. 567-572
    • Inoue, K.1    Sekiyama, K.2    Yamada, M.3    Watanabe, T.4    Yasuda, H.5    Yoshiba, M.6
  • 37
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase C(theta) in T cell activation
    • Isakov, N., and A. Altman. 2002. Protein kinase C(theta) in T cell activation. Annu. Rev. Immunol. 20:761-794.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 38
    • 0026596383 scopus 로고
    • Nuclear factor of activated T cells contains Fos and Jun
    • Jain, J., P. G. McCaffrey, V. E. Valge-Archer, and A. Rao. 1992. Nuclear factor of activated T cells contains Fos and Jun. Nature 356:801-804.
    • (1992) Nature , vol.356 , pp. 801-804
    • Jain, J.1    McCaffrey, P.G.2    Valge-Archer, V.E.3    Rao, A.4
  • 39
    • 0032418812 scopus 로고    scopus 로고
    • The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
    • Kalams, S. A., and B. D. Walker. 1998. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J. Exp. Med. 188:2199-2204.
    • (1998) J. Exp. Med. , vol.188 , pp. 2199-2204
    • Kalams, S.A.1    Walker, B.D.2
  • 40
    • 0033559545 scopus 로고    scopus 로고
    • The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: Proof of cross-talk with the I kappa B kinase cascade
    • Kempiak, S. J., T. S. Hiura, and A. E. Nel. 1999. The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the I kappa B kinase cascade. J. Immunol. 162:3176-3187.
    • (1999) J. Immunol. , vol.162 , pp. 3176-3187
    • Kempiak, S.J.1    Hiura, T.S.2    Nel, A.E.3
  • 41
    • 0033556262 scopus 로고    scopus 로고
    • Suppression of host immune response by the core protein of hepatitis C virus: Possible implications for hepatitis C virus persistence
    • Large, M. K., D. J. Kittlesen, and Y. S. Hahn. 1999. Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus persistence. J. Immunol. 162:931-938.
    • (1999) J. Immunol. , vol.162 , pp. 931-938
    • Large, M.K.1    Kittlesen, D.J.2    Hahn, Y.S.3
  • 44
    • 0029975023 scopus 로고    scopus 로고
    • Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells
    • Li, W., C. D. Whaley, A. Mondino, and D. L. Mueller. 1996. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Science 271:1272-1276.
    • (1996) Science , vol.271 , pp. 1272-1276
    • Li, W.1    Whaley, C.D.2    Mondino, A.3    Mueller, D.L.4
  • 45
    • 0000163169 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • D. M. Knipe et al. (ed.), Lippincott Williams & Wilkins, Philadelphia, Pa.
    • Lindenbach, B., and C. Rice. 2001. Flaviviridae: the viruses and their replication, p. 991-1041. In D. M. Knipe et al. (ed.), Fields virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, Pa.
    • (2001) Fields Virology, 4th Ed. , pp. 991-1041
    • Lindenbach, B.1    Rice, C.2
  • 46
    • 0028924419 scopus 로고
    • Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation
    • Liu, Y., M. Gorospe, C. Yang, and N. J. Holbrook. 1995. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J. Biol. Chem. 270:8377-8380.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8377-8380
    • Liu, Y.1    Gorospe, M.2    Yang, C.3    Holbrook, N.J.4
  • 49
    • 0035958007 scopus 로고    scopus 로고
    • The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages
    • Ma, W., W. Lim, K. Gee, S. Aucoin, D. Nandan, M. Kozlowski, F. Diaz-Mitoma, and A. Kumar. 2001. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J. Biol. Chem. 276:13664-13674.
    • (2001) J. Biol. Chem. , vol.276 , pp. 13664-13674
    • Ma, W.1    Lim, W.2    Gee, K.3    Aucoin, S.4    Nandan, D.5    Kozlowski, M.6    Diaz-Mitoma, F.7    Kumar, A.8
  • 51
    • 0034283018 scopus 로고    scopus 로고
    • Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
    • Macian, F., C. Garcia-Rodriguez, and A. Rao. 2000. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19:4783-4795.
    • (2000) EMBO J. , vol.19 , pp. 4783-4795
    • Macian, F.1    Garcia-Rodriguez, C.2    Rao, A.3
  • 52
    • 0035971436 scopus 로고    scopus 로고
    • Partners in transcription: NFAT and AP-1
    • Macian, F., C. Lopez-Rodriguez, and A. Rao. 2001. Partners in transcription: NFAT and AP-1. Oncogene 20:2476-2489.
    • (2001) Oncogene , vol.20 , pp. 2476-2489
    • Macian, F.1    Lopez-Rodriguez, C.2    Rao, A.3
  • 53
    • 0031204429 scopus 로고    scopus 로고
    • Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
    • McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319-1327.
    • (1997) J. Immunol. , vol.159 , pp. 1319-1327
    • McGuire, K.L.1    Iacobelli, M.2
  • 54
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale, G., R. Bertoni, V. Lamonaca, A. Valli, M. Massari, C. Mori, M. G. Rumi, M. Houghton, F. Fiaccadori, and C. Ferrari. 1996. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Investig. 98:706-714.
    • (1996) J. Clin. Investig. , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3    Valli, A.4    Massari, M.5    Mori, C.6    Rumi, M.G.7    Houghton, M.8    Fiaccadori, F.9    Ferrari, C.10
  • 56
  • 58
    • 0027450038 scopus 로고
    • Peripheral blood leukocytes serve as a possible extrahepatic site for hepatitis C virus replication
    • Muller, H. M., E. Pfaff, T. Goeser, B. Kallinowski, C. Solbach, and L. Theilmann. 1993. Peripheral blood leukocytes serve as a possible extrahepatic site for hepatitis C virus replication. J. Gen. Virol. 74:669-676.
    • (1993) J. Gen. Virol. , vol.74 , pp. 669-676
    • Muller, H.M.1    Pfaff, E.2    Goeser, T.3    Kallinowski, B.4    Solbach, C.5    Theilmann, L.6
  • 59
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse
    • Nel, A. E. 2002. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin. Immunol. 109:758-770.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 758-770
    • Nel, A.E.1
  • 60
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Neumann, A. U., N. P. Lam, H. Dahari, D. R. Gretch, T. E. Wiley, T. J. Layden, and A. S. Perelson. 1998. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282:103-107.
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 61
    • 0027518679 scopus 로고
    • Characterization of the nuclear and cytoplasmic components of lymphoid specific nuclear factor of activated T cells (NF-AT) complex
    • Northrop, J. P., K. S. Ullman, and G. R. Crabtree. 1993. Characterization of the nuclear and cytoplasmic components of lymphoid specific nuclear factor of activated T cells (NF-AT) complex. J. Biol. Chem. 268:2917-2923.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2917-2923
    • Northrop, J.P.1    Ullman, K.S.2    Crabtree, G.R.3
  • 62
    • 0027364319 scopus 로고
    • Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells
    • Penix, L., W. M. Weaver, Y. Pang, H. A. Young, and C. B. Wilson. 1993. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J. Exp. Med. 178:1483-1496.
    • (1993) J. Exp. Med. , vol.178 , pp. 1483-1496
    • Penix, L.1    Weaver, W.M.2    Pang, Y.3    Young, H.A.4    Wilson, C.B.5
  • 63
    • 0035928765 scopus 로고    scopus 로고
    • Hepatitis C virus core protein: Intriguing properties and functional relevance
    • Ray, R. B., and R. Ray. 2001. Hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol. Lett. 202:149-156.
    • (2001) FEMS Microbiol. Lett. , vol.202 , pp. 149-156
    • Ray, R.B.1    Ray, R.2
  • 64
    • 0026499517 scopus 로고
    • The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines
    • Rhoades, K., S. Golub, and J. Economou. 1992. The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines. J. Biol. Chem. 267:22102-22107.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22102-22107
    • Rhoades, K.1    Golub, S.2    Economou, J.3
  • 65
    • 0027936441 scopus 로고
    • AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
    • Rincon, M., and R. A. Flavell. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13:4370-4381.
    • (1994) EMBO J. , vol.13 , pp. 4370-4381
    • Rincon, M.1    Flavell, R.A.2
  • 66
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1-8.
    • (1996) J. Exp. Med. , vol.184 , pp. 1-8
    • Schwartz, R.H.1
  • 68
    • 0029025964 scopus 로고
    • The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
    • Serfling, E., A. Avots, and M. Neumann. 1995. The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta 1263:181-200.
    • (1995) Biochim. Biophys. Acta , vol.1263 , pp. 181-200
    • Serfling, E.1    Avots, A.2    Neumann, M.3
  • 69
    • 0034330698 scopus 로고    scopus 로고
    • Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection
    • Shankar, P., M. Russo, B. Harnisch, M. Patterson, P. Skolnik, and J. Lieberman. 2000. Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood 96:3094-3101.
    • (2000) Blood , vol.96 , pp. 3094-3101
    • Shankar, P.1    Russo, M.2    Harnisch, B.3    Patterson, M.4    Skolnik, P.5    Lieberman, J.6
  • 70
    • 0031001510 scopus 로고    scopus 로고
    • CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
    • Shapiro, V. S., K. E. Truitt, J. B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol. Cell. Biol. 17:4051-4058.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4051-4058
    • Shapiro, V.S.1    Truitt, K.E.2    Imboden, J.B.3    Weiss, A.4
  • 73
    • 0031797725 scopus 로고    scopus 로고
    • Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors
    • Shrivastava, A., S. K. Manna, R. Ray, and B. B. Aggarwal. 1998. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J. Virol. 72:9722-9728.
    • (1998) J. Virol. , vol.72 , pp. 9722-9728
    • Shrivastava, A.1    Manna, S.K.2    Ray, R.3    Aggarwal, B.B.4
  • 74
    • 0036720777 scopus 로고    scopus 로고
    • Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model
    • Soguero, C., M. Joo, K. A. Chianese-Bullock, D. T. Nguyen, K. Tung, and Y. S. Hahn. 2002. Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J. Virol. 76:9345-9354.
    • (2002) J. Virol. , vol.76 , pp. 9345-9354
    • Soguero, C.1    Joo, M.2    Chianese-Bullock, K.A.3    Nguyen, D.T.4    Tung, K.5    Hahn, Y.S.6
  • 75
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736.
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Neriah, Y.6
  • 76
    • 0037303112 scopus 로고    scopus 로고
    • Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: The apoptotic effects of virus infection
    • Sung, V. M.-H., S. Shimodaira, A. L. Doughty, G. R. Picchio, H. Can, T. S. B. Yen, K. L. Lindsay, A. M. Levine, and M. M. C. Lai. 2003. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J. Virol. 77:2134-2146.
    • (2003) J. Virol. , vol.77 , pp. 2134-2146
    • Sung, V.M.-H.1    Shimodaira, S.2    Doughty, A.L.3    Picchio, G.R.4    Can, H.5    Yen, T.S.B.6    Lindsay, K.L.7    Levine, A.M.8    Lai, M.M.C.9
  • 77
    • 0027305687 scopus 로고
    • Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
    • Szabo, S. J., J. S. Gold, T. L. Murphy, and K. M. Murphy. 1993. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13:4793-4805.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4793-4805
    • Szabo, S.J.1    Gold, J.S.2    Murphy, T.L.3    Murphy, K.M.4
  • 78
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor, D. R., S. T. Shi, P. R. Romano, G. N. Barber, and M. M. Lai. 1999. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 285:107-110.
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.5
  • 80
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme, R., D. Oldach, K. M. Chang, C. Steiger, S. C. Ray, and F. V. Chisari. 2001. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194:1395-1406.
    • (2001) J. Exp. Med. , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 81
    • 0031026553 scopus 로고    scopus 로고
    • Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
    • Tsai, S. L., Y. F. Liaw, M. H. Chen, C. Y. Huang, and G. C. Kuo. 1997. Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 25:449-458.
    • (1997) Hepatology , vol.25 , pp. 449-458
    • Tsai, S.L.1    Liaw, Y.F.2    Chen, M.H.3    Huang, C.Y.4    Kuo, G.C.5
  • 82
    • 0033602707 scopus 로고    scopus 로고
    • Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli
    • Tsuchihara, K., M. Hijikata, K. Fukuda, T. Kuroki, N. Yamamoto, and K. Shimotohno. 1999. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli. Virology 258:100-107.
    • (1999) Virology , vol.258 , pp. 100-107
    • Tsuchihara, K.1    Hijikata, M.2    Fukuda, K.3    Kuroki, T.4    Yamamoto, N.5    Shimotohno, K.6
  • 85
    • 0032101707 scopus 로고    scopus 로고
    • Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
    • Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101-3111.
    • (1998) EMBO J. , vol.17 , pp. 3101-3111
    • Werlen, G.1    Jacinto, E.2    Xia, Y.3    Karin, M.4
  • 86
    • 0031570824 scopus 로고    scopus 로고
    • CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes
    • Woitas, R. P., M. Lechmann, G. Jung, R. Kaiser, T. Sauerbruch, and U. Spengler. 1997. CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes. J. Immunol. 159:1012-1018.
    • (1997) J. Immunol. , vol.159 , pp. 1012-1018
    • Woitas, R.P.1    Lechmann, M.2    Jung, G.3    Kaiser, R.4    Sauerbruch, T.5    Spengler, U.6


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