The targeted expression of the human interleukin-2/interferon α2b fused gene in α-fetoprotein-expressing hepatocellular carcinoma cells

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 2, 1999, Pages 77-82

  He, Ping ^a   Tang, Zhao You ^a   Liu, Bin Bin ^a   Ye, Sheng Long ^a   Liu, Yin Kun ^a  

^a ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Human AFP enhancer; Human albumin promoter; Human IL 2 IFN 2b fused gene; Targeted expression

Indexed keywords

ALPHA FETOPROTEIN; ALPHA2B INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR;

ARTICLE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

EID: 0032904436     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050245     Document Type: Article

References (18)

1. Arbuthnot P, Bralet MP, Thomassin H, Danan J-L, Brechot C, Ferry N (1995) Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by α-fetoprotein but not insulinlike growth factor II regulatory sequences. Hepatology 22:1788-1796
2. Arbuthnot P, Bralet MP, Lejossic C, Dedieu JF, Perricaudet M, Brechot C, Ferry N (1996) In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adeoviral vector. Hum Gene Ther 7:1503-1514
3. Brttke T, McCubrey JA, Owen TC (1993) Use of an aqueous soluble tetrazolium/formazan assay to measure viabilty and proliferation of lymphokine-dependent cell lines. J Immunol Methods 157:233-238
4. Bukowski RM, Olencki T, Wang Q (1997) Phase II trial of interleukin-2 and interferon-alpha in patients with renal cell carcinoma: clinical results and immunologic correlates of response, J Immunother 20:301-11
5. Cao G, Kuriyama S, Du P, Sakamoto T, Kong X, Masui K, Qi Z (1997) Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor α gene transfer. Gastroenterology 112:501-510
6. Hathorn RW, Tso CL, Kaboo R, Pang S, Figlin R, Sawyers C, Dekernion JB, Belldegrun A (1994) In vitro modulation of the invasive and metastatic potentials of human renal cell carcinoma by interleukin-2 and/or interferon-alpha gene transfer. Cancer 74:1904-1911
7. Hayashi Y, Chan J, Nakabayashi H, Hashimoto T, Tamaoki T (1992) Identification and characterization of two enhancers of the human albumin gene. J Biol Chem 267:14 580-14 585
8. Huber BE, Richards CA, Krenitsky TA (1991) Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc Natl Acad Sci USA 88:8039-8043
9. Kanai F, Shiratori Y, Yoshida Y, Wakimoto H, Hamada H, Kanegae Y, Saito I, Nakabayashi H, Tamaoki T, Tanaka T, Lan K-H, Kato N, Shiina S, Omata M (1996) Gene therapy for α-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex thymidine kinase gene. Hepatology 23:1359-1368
10. Kanai F, Lan KH, Shiratori Y, Tanaka T, Ohashi M, Okudaira T, Yoshida Y, Wakimoto H, Hamada H, Nakabayashi H, Tamaoki T, Omata M (1997) In vivo gene therapy for α-feto-protein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase. Cancer Res 57:461-465
11. Kaneko S, Hallenbeck P, Kotani T, Nakabatashi H, Mcgarrity G, Tamaoki T, Anderson WF, Chiang TL (1995) Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res 55:5283-5287
12. Lissoni P, Pittalis S, Ardizzoia A, Brivio F, Barni S, Tancini G, Pelizzoni F, Maestroni GJ, Zubelewicz B, Braczkowski R (1996) Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin. Support Care Cancer 4:311-316
13. Macri P, Gordon JW (1994) Delayed morbidity and mortality of albumin-SV40 T-antigen transgenic mice after insertion of an α-fetoprotein/herpes virus thymidine kinase transgene and treatment with ganciclovir. Hum Gene Ther 5:175-182
14. Sakai M, Morinaga T, Urano Y, Watanabe K, Wegmann TG, Tamaoki T (1985) The human α-fetoprotein gene. J Biol Chem 260:5055-5060
15. Su H, Chang JC, Xu SM, Kan YW (1996) Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther 7:463-470
16. Tilghman SM (1985) The structure and regulation of the α-feto-protein and albumin genes. In: Maclean N (ed) Oxford surveys in eukaryotic genes, vol 2. Oxford University Press, Oxford, pp 160-206
17. Tilghman SM, Belayew A (1982) Transcriptional control of the murine albumin: alpha-fetoprotein locus during development. Proc Natl Acad Sci USA 79:5254-5257
18. Watanabe K, Saito A, Tamaoki T (1987) Cell-specific enhancer activity in a far upstream region of the human α-fetoprotein gene. J Biol Chem 262:4812-4818