Dengue virus RNA polymerase NS5: A potential therapeutic target?

Current Drug Targets

Volumn 7, Issue 12, 2006, Pages 1623-1638

  Rawlinson, Stephen M ^a   Pryor, Melinda J ^a   Wright, Peter J ^a   Jans, David A ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b Australian Government Australian Research Council   (Australia)

Author keywords

Antivirals; Dengue; NS5; Nuclear protein import; Nuclear targeting; RNA dependent RNA polymerase; Therapeutics

Indexed keywords

ANTIVIRUS AGENT; DENGUE VACCINE; DNA BINDING PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JTK 003; KARYOPHERIN; KARYOPHERIN ALPHA; KARYOPHERIN BETA; LIVE VACCINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN P53; RIBAVIRIN; RNA POLYMERASE; TRANSCRIPTION FACTOR; VIRUS RNA;

ANTIBODY DEPENDENT ENHANCEMENT; ANTIVIRAL ACTIVITY; CELLULAR DISTRIBUTION; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DENGUE; DENGUE VIRUS; DISEASE CARRIER; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEASIBILITY STUDY; FLAVIVIRUS; GENE CONTROL; GENE INTERACTION; GENE TARGETING; GENE THERAPY; HIGH THROUGHPUT SCREENING; HUMAN; INFECTION CONTROL; INTRACELLULAR TRANSPORT; MOLECULAR BIOLOGY; MOSQUITO; NONHUMAN; NUCLEAR PORE COMPLEX; OPEN READING FRAME; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; VIRUS RECOMBINATION; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; DENGUE VIRUS; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BIOSYNTHESIS; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 33845322955     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006779025383     Document Type: Review

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