A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-methyltransferase domain by ribavirin 5′-triphosphate

Journal of Biological Chemistry

Volumn 279, Issue 34, 2004, Pages 35638-35643

  Benarroch, Delphine ^a   Egloff, Marie Pierre ^a   Mulard, Laurence ^b   Guerreiro, Catherine ^b   Romette, Jean Louis ^a   Canard, Bruno ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; COMPLEXATION; DISEASE CONTROL; ENZYME INHIBITION; MOLECULAR BIOLOGY; PHOSPHATES; VIRUSES;

NUCLEOSIDES; RIBAVIRIN; TRIPHOSPHATES;

RNA;

2' O METHYLTRANSFERASE; 5 ETHYNYL 4 IMIDAZOLECARBOXAMIDE 1 RIBOSIDE; ACICLOVIR; ANTIVIRUS AGENT; GUANOSINE DERIVATIVE; GUANOSINE TRIPHOSPHATE; MESSENGER RNA; METHYLTRANSFERASE; NUCLEOSIDE ANALOG; PHOSPHORUS 32; RIBAVIRIN; RIBAVIRIN DERIVATIVE; RIBAVIRIN TRIPHOSPHATE; TRITIUM; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CRYSTALLIZATION; DENGUE; DENGUE VIRUS; ENZYME INHIBITION; ENZYME PURIFICATION; FLAVIVIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; NONHUMAN; NS5 DENGUE VIRUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; VIRUS GENOME; VIRUS INFECTION; VIRUS INHIBITION;

BINDING SITES; DENGUE; DENGUE VIRUS; METHYLTRANSFERASES; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

DENGUE VIRUS; FLAVIVIRUS; RNA VIRUSES;

EID: 4143116991     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400460200     Document Type: Article

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