The use of cell-penetrating peptides as a tool for gene regulation

Drug Discovery Today

Volumn 9, Issue 9, 2004, Pages 395-402

  Järver, Peter ^a   Langel, Ülo ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Biochemistry; Cell penetrating peptides; Cellular delivery; Chemical Biology; Drug Discovery; Gene regulation; Membrane translocation; Pharmaceutical Science; Transport

Indexed keywords

ADENOVIRUS VECTOR; ALANYLGLYCYLLYSYLLEUCYLLEUCYLGLYCYLLYSYLISOLEUCYLASPARAGINYLLEUCYLLYSYLA LAN YLLEUCYLALANYLALANYLLEUCYLALANYLLYSYLLYSYLISOLEUCYLLEUCINAMIDE; ANTISENSE OLIGONUCLEOTIDE; ARGINYLARGINYLARGINYLARGINYLARGINYLARGINYLARGININE; ARGINYLGLUTAMINYLISOLEUCYLLYSYLISOLEUCYLTRYPTOPHYLPHENYLALANYLGLUTAMINYL ASP ARAGINYLARGINYLARGINYLMETHIONYLLYSYLTRYPTOPHYLLYSYLLYSINE; CARRIER PROTEIN; CRE RECOMBINASE; DRUG CARRIER; GLYCYLALANYLLEUCYLPHENYLALANYLLEUCYLGLYCYLTRYPTOPHYLLEUCYLGLYCYLALANYLAL ANY LGLYCYLSERYLTHREONYLMETHIONYLGLYCYLALANYLPROLYLLYSYLLYSYLLYSYLARGINYLLYSYLVALINA MIDE; GLYCYLARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGINYLPROL YLP ROLYLGLUTAMINE; LEUCYLLEUCYLISOLEUCYLISOLEUCYLLEUCYLARGINYLARGINYLISOLEUCYLARGINYLLYSYLG LUT AMINYLALANYLHISTIDYLALANYLHISTIDYLSERYLLYSINAMIDE; LYSYLLEUCYLALANYLLEUCYLLYSYLLEUCYLALANYLLEUCYLLYSYLALANYLLEUCYLLYSYLALAN YLA LANYLLEUCYLLYSYLLEUCYLALANINAMIDE; MYC PROTEIN; NEUROPROTECTIVE AGENT; PEPTIDE NUCLEIC ACID; POLYCATION; POLYETHYLENEIMINE; PROLYLLYSYLLYSYLLYSYLARGINYLLYSYLVALINE; STRESS ACTIVATED PROTEIN KINASE; SYNTHETIC PEPTIDE; THREONYLARGINYLSERYLSERYLARGINYLALANYLGLYCYLLEUCYLGLUTAMINYLPHENYLALANYL PRO LYLVALYLGLYCYLARGINYLVALYLHISTIDYLARGINYLLEUCYLLEUCYLARGINYLLYSINE; TRYPTOPHYLGLUTAMYLALANYLLYSYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLEUCYLAL ANY LLEUCYLALANYLLYSYLHISTIDYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLALANYLLEUCYLLY SYLALANYLCYSTEINYLGLUTAMYLGLUTAMYLALANINE; TYROSYLALANYLARGINYLALANYLALANYLALANYLARGINYLGLUTAMYLALANYLARGINYLALANIN E; UNCLASSIFIED DRUG; VIRUS VECTOR;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT; APOPTOSIS; CAVEOLA; CELL GROWTH; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; COVALENT BOND; CYTOSOL; DISULFIDE BOND; DNA BINDING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG PENETRATION; DRUG SYNTHESIS; ENDOCYTOSIS; ENDOSOME; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC ENGINEERING; GENETIC RECOMBINATION; HUMAN; INTERNALIZATION; LYSOSOME; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; RNA BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TYROSYLALANYLARGINYLALANYLALANYLALANYLGLUTAMINYLALANYLARGINYLALANINE;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE PERMEABILITY; DRUG DELIVERY SYSTEMS; GENE SILENCING; GENETIC VECTORS; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDES; PLASMIDS; PROTEIN TRANSPORT; RNA, SMALL INTERFERING;

EID: 11144356131     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03042-9     Document Type: Review

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