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Volumn 1, Issue 6, 2005, Pages 787-797

The role of Wnt signaling in cancer and stem cells

Author keywords

catenin; adenomatous polyposis coli; cancer; dishevelled; secreted Frizzled related protein; stem cells; Wnt inhibitory factor beta

Indexed keywords

WNT PROTEIN;

EID: 33845303957     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/14796694.1.6.787     Document Type: Review
Times cited : (64)

References (119)
  • 1
    • 0023653232 scopus 로고
    • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
    • Rijsewijk F, Schuermann M, Wagenaar E, Parren P, Weigel D, Nusse R: The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657 (1987).
    • (1987) Cell , vol.50 , pp. 649-657
    • Rijsewijk, F.1    Schuermann, M.2    Wagenaar, E.3    Parren, P.4    Weigel, D.5    Nusse, R.6
  • 2
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse R, Varmus HE: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109 (1982).
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 3
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y, Kypta R: Secreted antagonists of the Wnt signalling pathway. J. Cell. Sci. 116, 2627-2634 (2003).
    • (2003) J. Cell. Sci. , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 5
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P: Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 6
    • 0037778008 scopus 로고    scopus 로고
    • The Wnt signaling pathway and its role in tumor development
    • Lustig B, Behrens J: The Wnt signaling pathway and its role in tumor development. J. Cancer Res. Clin. Oncol. 129, 199-221 (2003).
    • (2003) J. Cancer Res. Clin. Oncol. , vol.129 , pp. 199-221
    • Lustig, B.1    Behrens, J.2
  • 8
    • 0036230877 scopus 로고    scopus 로고
    • DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis
    • Cohen ED, Mariol MC, Wallace RM et al.: DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev. Cell. 2, 437-448 (2002).
    • (2002) Dev. Cell. , vol.2 , pp. 437-448
    • Cohen, E.D.1    Mariol, M.C.2    Wallace, R.M.3
  • 9
    • 0032504052 scopus 로고    scopus 로고
    • Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    • Boutros M, Paricio N, Strutt D I, Mlodzik M: Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94, 109-118 (1998).
    • (1998) Cell , vol.94 , pp. 109-118
    • Boutros, M.1    Paricio, N.2    Strutt, D.I.3    Mlodzik, M.4
  • 10
    • 1642499116 scopus 로고    scopus 로고
    • A divergent canonical WNTsignaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules
    • Ciani L, Krylova O, Smalley MJ, Dale TC, Salinas PC: A divergent canonical WNTsignaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules. J. Cell Biol. 164, 243-253 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 243-253
    • Ciani, L.1    Krylova, O.2    Smalley, M.J.3    Dale, T.C.4    Salinas, P.C.5
  • 11
    • 13444267284 scopus 로고    scopus 로고
    • Secreted Frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in a-catenin-deficient human mesothelioma cells
    • He B, Lee AY, Dadfarmay S et al.: Secreted Frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in a-catenin-deficient human mesothelioma cells. Cancer Res. 65, 743-748 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 743-748
    • He, B.1    Lee, A.Y.2    Dadfarmay, S.3
  • 12
    • 4644302254 scopus 로고    scopus 로고
    • Dickkopf-1 antagonizes Wnt signaling independent of a-catenin in human mesothelioma
    • Lee AY, He B, You L et al.: Dickkopf-1 antagonizes Wnt signaling independent of a-catenin in human mesothelioma. Biochem. Biophys. Res. Commun. 323, 1246-1250 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 1246-1250
    • Lee, A.Y.1    He, B.2    You, L.3
  • 13
    • 2442694379 scopus 로고    scopus 로고
    • Inhibition of Wnt-1 signaling induces apoptosis in a- catenin-deficient mesothelioma cells
    • You L, He B, Uematsu K et al.: Inhibition of Wnt-1 signaling induces apoptosis in a- catenin-deficient mesothelioma cells. Cancer Res. 64, 3474-3478 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3474-3478
    • You, L.1    He, B.2    Uematsu, K.3
  • 14
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and Frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • Rhee CS, Sen M, Lu D et al.: Wnt and Frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 21, 6598-6605 (2002).
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3
  • 15
    • 16444374026 scopus 로고    scopus 로고
    • Constitutive activation of the Wnt/a-catenin signalling pathway in acute myeloid leukaemia
    • Simon M, Grandage VL, Linch DC, Khwaja A: Constitutive activation of the Wnt/a-catenin signalling pathway in acute myeloid leukaemia. Oncogene 24, 2410-2420 (2005).
    • (2005) Oncogene , vol.24 , pp. 2410-2420
    • Simon, M.1    Grandage, V.L.2    Linch, D.C.3    Khwaja, A.4
  • 16
    • 1542267803 scopus 로고    scopus 로고
    • Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
    • Lu D, ZhaoY, Tawatao R et al.: Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 101, 3118-3123 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3118-3123
    • Lu, D.1    Zhaoy Tawatao, R.2
  • 17
    • 0030949463 scopus 로고    scopus 로고
    • Activation of a-catenin-Tcf signaling in colon cancer by mutations in a-catenin or APC
    • Morin PJ, Sparks AB, KorinekW et al.: Activation of a-catenin-Tcf signaling in colon cancer by mutations in a-catenin or APC. Science 275, 1787-1790 (1997).
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Korinekw S.Ab2
  • 19
    • 0032937232 scopus 로고    scopus 로고
    • Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
    • Rimm DL, Caca K, Hu G, Harrison FB, Fearon ER: Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am. J. Pathol. 154, 325-329 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 325-329
    • Rimm, D.L.1    Caca, K.2    Hu, G.3    Harrison, F.B.4    Fearon, E.R.5
  • 20
  • 21
    • 0033795924 scopus 로고    scopus 로고
    • A-catenin in soft tissue sarcomas: Expression is related to proliferative activity in highgrade sarcomas
    • Kuhnen C, Herter P, Muller O et al.: a-catenin in soft tissue sarcomas: expression is related to proliferative activity in highgrade sarcomas. Mod. Pathol. 13, 1005-1013 (2000).
    • (2000) Mod. Pathol. , vol.13 , pp. 1005-1013
    • Kuhnen, C.1    Herter, P.2    Muller, O.3
  • 22
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • Mao J, Wang J, Liu B et al.: Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell. 7, 801-809 (2001).
    • (2001) Mol. Cell. , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3
  • 24
    • 0037229938 scopus 로고    scopus 로고
    • Runnin with the Dvl: Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    • Wharton KA: Runnin with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev. Biol. 253, 1-17 (2003).
    • (2003) Dev. Biol. , vol.253 , pp. 1-17
    • Wharton, K.A.1
  • 25
    • 33846990139 scopus 로고    scopus 로고
    • Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling
    • Itoh K, Brott BK, Bae G, Ratcliffe MJ, Sokol SY: Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J. Biol. 4, 3 (2005).
    • (2005) J. Biol. , vol.4 , pp. 3
    • Itoh, K.1    Brott, B.K.2    Bae, G.3    Ratcliffe, M.J.4    Sokol, S.Y.5
  • 26
    • 0030779038 scopus 로고    scopus 로고
    • Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
    • Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW: Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem. 272, 24735-24738 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24735-24738
    • Orford, K.1    Crockett, C.2    Jensen, J.P.3    Weissman, A.M.4    Byers, S.W.5
  • 27
    • 0036571011 scopus 로고    scopus 로고
    • Axinmediated CKI phosphorylation of a- catenin at ser 45: A molecular switch for the Wnt pathway
    • Amit S, Hatzubai A, BirmanY et al.: Axinmediated CKI phosphorylation of a- catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16, 1066-1076 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1066-1076
    • Amit, S.1    Birmany, H.A.2
  • 28
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3a and a-catenin and promotes GSK-3a-dependent phosphorylation of a-catenin
    • Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A: Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3a and a-catenin and promotes GSK-3a-dependent phosphorylation of a-catenin. EMBO J. 17, 1371-1384 (1998).
    • (1998) EMBO J. , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 29
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with a-catenin, APC, and GSK3a
    • Behrens J, Jerchow BA, Wurtele M et al.: Functional interaction of an axin homolog, conductin, with a-catenin, APC, and GSK3a. Science 280, 596-599 (1998).
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.A.2    Wurtele, M.3
  • 30
    • 0037155691 scopus 로고    scopus 로고
    • Control of a-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu C, Li Y, Semenov, M et al.: Control of a-catenin phosphorylation/ degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3
  • 31
    • 0033993931 scopus 로고    scopus 로고
    • Interaction of dishevelled and Xenopus axinrelated protein is required for Wnt signal transduction
    • Itoh K, Antipova A, Ratcliffe JM, Soko S: Interaction of dishevelled and Xenopus axinrelated protein is required for Wnt signal transduction. Mol. Cell. Biol. 20(6), 2228-2238 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.6 , pp. 2228-2238
    • Itoh, K.1    Antipova, A.2    Ratcliffe, J.M.3    Soko, S.4
  • 32
    • 0030265570 scopus 로고    scopus 로고
    • A Frizzled homolog functions in a vertebrate Wnt signaling pathway
    • Yang-Snyder J, Miller JR, Brown JD, Lai CJ, Moon RT: A Frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6(10), 1302-1306 (1996).
    • (1996) Curr. Biol. , vol.6 , Issue.10 , pp. 1302-1306
    • Yang-Snyder, J.1    Miller, J.R.2    Brown, J.D.3    Lai, C.J.4    Moon, R.T.5
  • 33
    • 0032497485 scopus 로고    scopus 로고
    • The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
    • Roose J, Molenaar M, Peterson J et al.: The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395, 608-612 (1998).
    • (1998) Nature , vol.395 , pp. 608-612
    • Roose, J.1    Molenaar, M.2    Peterson, J.3
  • 34
    • 0032941717 scopus 로고    scopus 로고
    • Regulation of LEF-1/TCF transcription factors by Wnt and other signals
    • Eastman Q, Grosschedl R: Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell. Biol. 11, 233-240 (1999).
    • (1999) Curr. Opin. Cell. Biol. , vol.11 , pp. 233-240
    • Eastman, Q.1    Grosschedl, R.2
  • 35
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of a-catenin with the transcription factor LEF-1
    • Behrens J, von Kries JP, Kuhl M et al.: Functional interaction of a-catenin with the transcription factor LEF-1. Nature 382, 638-642 (1996).
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1    Von Kries, J.P.2    Kuhl, M.3
  • 36
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C et al.: Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 37
    • 0033119801 scopus 로고    scopus 로고
    • A -catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F: a-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426 (1999).
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 38
    • 0037023584 scopus 로고    scopus 로고
    • Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
    • Kramps T, Peter O, Brunner E et al.: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109, 47-60 (2002).
    • (2002) Cell , vol.109 , pp. 47-60
    • Kramps, T.1    Peter, O.2    Brunner, E.3
  • 39
    • 3242706980 scopus 로고    scopus 로고
    • Pygopus and Legless target Armadillo/a-catenin to the nucleus to enable its transcriptional coactivator function
    • Townsley FM, Cliffe A, Bienz M: Pygopus and Legless target Armadillo/a-catenin to the nucleus to enable its transcriptional coactivator function. Nature Cell Biol. 6(7), 626-633 (2004).
    • (2004) Nature Cell Biol. , vol.6 , Issue.7 , pp. 626-633
    • Townsley, F.M.1    Cliffe, A.2    Bienz, M.3
  • 40
    • 21844437361 scopus 로고    scopus 로고
    • Pygopus and legless provide essential transcriptional coactivator functions to Armadillo/a-catenin
    • Hoffmans R, Stdeli R, Basler K: Pygopus and legless provide essential transcriptional coactivator functions to Armadillo/a-catenin. Curr. Biol. 15(13), 1207-1211 (2005).
    • (2005) Curr. Biol. , vol.15 , Issue.13 , pp. 1207-1211
    • Hoffmans, R.1    Stdeli, R.2    Basler, K.3
  • 41
    • 0043215023 scopus 로고    scopus 로고
    • Expression and regulation of WNT1 in human cancer: Upregulation of WNT1 by a-estradiol in MCF-7 cells
    • Katoh M: Expression and regulation of WNT1 in human cancer: upregulation of WNT1 by a-estradiol in MCF-7 cells. Int. J. Oncol. 22, 209-212 (2003).
    • (2003) Int. J. Oncol. , vol.22 , pp. 209-212
    • Katoh, M.1
  • 42
    • 0036154038 scopus 로고    scopus 로고
    • Expression of frizzled-related protein and Wntsignalling molecules in invasive human breast tumours
    • Wong SC, Lo SF, Lee KC et al.: Expression of frizzled-related protein and Wntsignalling molecules in invasive human breast tumours. J. Pathol. 196, 145-153 (2002).
    • (2002) J. Pathol. , vol.196 , pp. 145-153
    • Wong, S.C.1    Lo, S.F.2    Lee, K.C.3
  • 43
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    • He B, You L, Uematsu K et al.: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6, 7-14 (2004).
    • (2004) Neoplasia , vol.6 , pp. 7-14
    • He, B.1    You, L.2    Uematsu, K.3
  • 44
    • 0026549691 scopus 로고
    • Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors
    • Roelink H, Wagenaar E, Nusse R: Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene 7, 487-492 (1992).
    • (1992) Oncogene , vol.7 , pp. 487-492
    • Roelink, H.1    Wagenaar, E.2    Nusse, R.3
  • 45
    • 0031735293 scopus 로고    scopus 로고
    • Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified proto oncogenes MYCN, MET, WNT2, and ERBB2
    • Nessling M, Solinas-Toldo S, Wilgenbus KK, Borchard F, Lichter P: Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified proto oncogenes MYCN, MET, WNT2, and ERBB2. Genes Chromosomes Cancer 23, 307-316 (1998).
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 307-316
    • Nessling, M.1    Solinas-Toldo, S.2    Wilgenbus, K.K.3    Borchard, F.4    Lichter, P.5
  • 46
    • 0035930967 scopus 로고    scopus 로고
    • WNT2B2 mRNA, upregulated in primary gastric cancer, is a positive regulator of the WNT-A-catenin-TCF signaling pathway
    • Katoh M, Kirikoshi H, Terasaki H, Shiokawa K: WNT2B2 mRNA, upregulated in primary gastric cancer, is a positive regulator of the WNT-a-catenin-TCF signaling pathway. Biochem. Biophys. Res. Commun. 289, 1093-1098 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.289 , pp. 1093-1098
    • Katoh, M.1    Kirikoshi, H.2    Terasaki, H.3    Shiokawa, K.4
  • 47
    • 9044224393 scopus 로고    scopus 로고
    • Evidence for the involvement of the Wnt 2 gene in human colorectal cancer
    • Vider BZ, Zimber A, Chastre E et al.: Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. Oncogene 12, 153-158 (1996).
    • (1996) Oncogene , vol.12 , pp. 153-158
    • Vider, B.Z.1    Zimber, A.2    Chastre, E.3
  • 49
    • 0141884398 scopus 로고    scopus 로고
    • Wnt ligand expression in malignant melanoma: Pilot study indicating correlation with histopathological features
    • Pham K, Milovanovic T, Barr RJ, Truong T, Holcombe RF: Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features. Mol. Pathol. 56, 280-285 (2003).
    • (2003) Mol. Pathol. , vol.56 , pp. 280-285
    • Pham, K.1    Milovanovic, T.2    Barr, R.J.3    Truong, T.4    Holcombe, R.F.5
  • 50
    • 4344570800 scopus 로고    scopus 로고
    • Inhibition of Wnt- 2-mediated signaling induces programmed cell death in non-small cell lung cancer cells
    • You L, He B, Xu Z et al.: Inhibition of Wnt- 2-mediated signaling induces programmed cell death in non-small cell lung cancer cells. Oncogene 23, 6170-6174 (2004).
    • (2004) Oncogene , vol.23 , pp. 6170-6174
    • You, L.1    He, B.2    Xu, Z.3
  • 51
    • 0031128225 scopus 로고    scopus 로고
    • WNTs modulate cell fate and behavior during vertebrate development
    • Moon RT, Brown JD, Torres M: WNTs modulate cell fate and behavior during vertebrate development. Trends Genet. 13, 157-162 (1997).
    • (1997) Trends Genet. , vol.13 , pp. 157-162
    • Moon, R.T.1    Brown, J.D.2    Torres, M.3
  • 52
    • 0345356929 scopus 로고    scopus 로고
    • Wnt5a inhibits B-cell proliferation and functions as a tumor suppressor in hematopoietic tissue
    • Liang H, Chen Q, Coles AH et al.: Wnt5a inhibits B-cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4, 349-360 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 349-360
    • Liang, H.1    Chen, Q.2    Coles, A.H.3
  • 53
    • 0036528247 scopus 로고    scopus 로고
    • Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
    • Weeraratna AT, Jiang Y, Hostetter G et al.: Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1, 279-288 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 279-288
    • Weeraratna, A.T.1    Jiang, Y.2    Hostetter, G.3
  • 54
    • 0345304776 scopus 로고    scopus 로고
    • Biological properties and gene expression associated with metastatic potential of human osteosarcoma
    • Nakano T, Tani M, Ishibashi Y et al.: Biological properties and gene expression associated with metastatic potential of human osteosarcoma. Clin. Exp. Metastasis 20, 665-674 (2003).
    • (2003) Clin. Exp. Metastasis , vol.20 , pp. 665-674
    • Nakano, T.1    Tani, M.2    Ishibashi, Y.3
  • 55
    • 0033731796 scopus 로고    scopus 로고
    • Altered HOX and WNT7A expression in human lung cancer
    • Calvo R, West J, Franklin W et al.: Altered HOX and WNT7A expression in human lung cancer. Proc. Natl Acad. Sci. USA 97, 12776-12781 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12776-12781
    • Calvo, R.1    West, J.2    Franklin, W.3
  • 56
    • 21244440303 scopus 로고    scopus 로고
    • Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through Frizzled-9-mediated growth gnhibition and promotion of cell differentiation
    • Winn RA, Marek L, Han SY et al.: Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through Frizzled-9-mediated growth gnhibition and promotion of cell differentiation. J. Biol. Chem. 280, 19625-19634 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 19625-19634
    • Winn, R.A.1    Marek, L.2    Han, S.Y.3
  • 57
    • 0033516577 scopus 로고    scopus 로고
    • Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling
    • Fedi P, Bafico A, Nieto Soria A et al.: Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274, 19465-19472 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 19465-19472
    • Fedi, P.1    Bafico, A.2    Nieto Soria, A.3
  • 58
    • 0036714307 scopus 로고    scopus 로고
    • Secreted Frizzledrelated proteins: Searching for relationships and patterns
    • Jones SE, Jomary C: Secreted Frizzledrelated proteins: searching for relationships and patterns. Bioessays 24, 811-820 (2002)
    • (2002) Bioessays , vol.24 , pp. 811-820
    • Jones, S.E.1    Jomary, C.2
  • 59
    • 0031870862 scopus 로고    scopus 로고
    • Upregulation of human secreted frizzled homolog in apoptosis and its downregulation in breast tumors
    • Zhou Z, Wang J, Han X, Zhou J, Linder S: Upregulation of human secreted frizzled homolog in apoptosis and its downregulation in breast tumors. Int. J. Cancer 78, 95-99 (1998).
    • (1998) Int. J. Cancer , vol.78 , pp. 95-99
    • Zhou, Z.1    Wang, J.2    Han, X.3    Zhou, J.4    Linder, S.5
  • 60
    • 0036429396 scopus 로고    scopus 로고
    • Human secreted frizzled-related protein is downregulated and induces apoptosis in human cervical cancer
    • Ko J, Ryu KS, Lee H et al.: Human secreted frizzled-related protein is downregulated and induces apoptosis in human cervical cancer. Exp. Cell. Res. 280, 280-287 (2002).
    • (2002) Exp. Cell. Res. , vol.280 , pp. 280-287
    • Ko, J.1    Ryu, K.S.2    Lee, H.3
  • 61
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive Wnt signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair KW et al.: Epigenetic inactivation of SFRP genes allows constitutive Wnt signaling in colorectal cancer. Nature Genet. 36, 417-422 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 62
    • 0035861791 scopus 로고    scopus 로고
    • Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer
    • To KF, Chan MW, Leung WK et al.: Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer. Life Sci. 70, 483-489 (2001).
    • (2001) Life Sci. , vol.70 , pp. 483-489
    • To, K.F.1    Chan, M.W.2    Leung, W.K.3
  • 63
    • 4444343396 scopus 로고    scopus 로고
    • Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma
    • Lee AY, He B, You L et al.: Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene 23, 6672-6676 (2004).
    • (2004) Oncogene , vol.23 , pp. 6672-6676
    • Lee, A.Y.1    He, B.2    You, L.3
  • 64
    • 1842535903 scopus 로고    scopus 로고
    • Shutting down Wnt signalactivated cancer
    • Taketo MM: Shutting down Wnt signalactivated cancer. Nature Genet. 36, 320-322 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 320-322
    • Taketo, M.M.1
  • 65
    • 0033118492 scopus 로고    scopus 로고
    • A new secreted protein that binds to Wnt proteins and inhibits their activities
    • Hsieh JC, Kodjabachian L, Rebbert ML et al.: A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398, 431-436 (1999).
    • (1999) Nature , vol.398 , pp. 431-436
    • Hsieh, J.C.1    Kodjabachian, L.2    Rebbert, M.L.3
  • 66
    • 0141995804 scopus 로고    scopus 로고
    • WIF1, a component of the Wnt pathway, is downregulated in prostate, breast, lung, and bladder cancer
    • Wissmann C, Wild PJ, Kaiser S et al.: WIF1, a component of the Wnt pathway, is downregulated in prostate, breast, lung, and bladder cancer. J. Pathol. 201, 204-212 (2003).
    • (2003) J. Pathol. , vol.201 , pp. 204-212
    • Wissmann, C.1    Wild, P.J.2    Kaiser, S.3
  • 67
    • 3142679453 scopus 로고    scopus 로고
    • Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
    • Mazieres J, He B, You L et al.: Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 64, 4717-4720, (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4717-4720
    • Mazieres, J.1    He, B.2    You, L.3
  • 68
    • 0035822594 scopus 로고    scopus 로고
    • Wnt signalling: Antagonistic Dickkopfs
    • Zorn AM: Wnt signalling: antagonistic Dickkopfs. Curr. Biol. 11, R592-R595 (2001).
    • (2001) Curr. Biol. , vol.11
    • Zorn, A.M.1
  • 69
    • 85047699343 scopus 로고    scopus 로고
    • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
    • Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS: Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 21, 878-889 (2002).
    • (2002) Oncogene , vol.21 , pp. 878-889
    • Shou, J.1    Ali-Osman, F.2    Multani, A.S.3    Pathak, S.4    Fedi, P.5    Srivenugopal, K.S.6
  • 70
    • 13944282066 scopus 로고    scopus 로고
    • The Wnt antagonist DICKKOPF-1 gene is a downstream target of a-catenin/TCF and is downregulated in human colon cancer
    • Gonzalez-Sancho JM, Aguilera O, Garcia JM et al.: The Wnt antagonist DICKKOPF-1 gene is a downstream target of a-catenin/TCF and is downregulated in human colon cancer. Oncogene 24, 1098-1103 (2005).
    • (2005) Oncogene , vol.24 , pp. 1098-1103
    • Gonzalez-Sancho, J.M.1    Aguilera, O.2    Garcia, J.M.3
  • 71
    • 11244323971 scopus 로고    scopus 로고
    • Dickkopf-3/REIC functions as a suppressor gene of tumor growth
    • Hsieh SY, Hsieh PS, Chiu CT, Chen WY: Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene 23, 9183-9189 (2004).
    • (2004) Oncogene , vol.23 , pp. 9183-9189
    • Hsieh, S.Y.1    Hsieh, P.S.2    Chiu, C.T.3    Chen, W.Y.4
  • 72
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis, P: Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272(5264), 1023-1026 (1996).
    • (1996) Science , vol.272 , Issue.5264 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 73
    • 5444265502 scopus 로고    scopus 로고
    • The Wnt connection to tumorigenesis
    • Behrens J, Lustig B: The Wnt connection to tumorigenesis. Int. J. Dev. Biol. 48, 477-487 (2004).
    • (2004) Int. J. Dev. Biol. , vol.48 , pp. 477-487
    • Behrens, J.1    Lustig, B.2
  • 74
    • 0036224749 scopus 로고    scopus 로고
    • The APC gene in colorectal cancer
    • Fodde R: The APC gene in colorectal cancer. Eur. J. Cancer 38, 867-871 (2002).
    • (2002) Eur. J. Cancer , vol.38 , pp. 867-871
    • Fodde, R.1
  • 75
    • 18744368086 scopus 로고    scopus 로고
    • Abnormalities of the APC/betacatenin pathway in endometrial cancer
    • Moreno-Bueno G, Hardisson D, Sanchez C et al.: Abnormalities of the APC/betacatenin pathway in endometrial cancer. Oncogene 21, 7981-7990 (2002).
    • (2002) Oncogene , vol.21 , pp. 7981-7990
    • Moreno-Bueno, G.1    Hardisson, D.2    Sanchez, C.3
  • 76
    • 0033784576 scopus 로고    scopus 로고
    • Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma
    • Schlosshauer PW, Pirog EC, Levine RL, Ellenson LH: Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma. Mod. Pathol. 13, 1066-1071 (2000).
    • (2000) Mod. Pathol. , vol.13 , pp. 1066-1071
    • Schlosshauer, P.W.1    Pirog, E.C.2    Levine, R.L.3    Ellenson, L.H.4
  • 78
    • 18344363708 scopus 로고    scopus 로고
    • APC/CTNNB1 (a-catenin) pathway alterations in human prostate cancers
    • Gerstein AV, Almeida TA, Zhao G et al.: APC/CTNNB1 (a-catenin) pathway alterations in human prostate cancers. Genes Chromosomes Cancer 34, 9-16 (2002).
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 9-16
    • Gerstein, A.V.1    Almeida, T.A.2    Zhao, G.3
  • 79
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the a-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • de La Coste A, Romagnolo B, Billuart P et al.: Somatic mutations of the a-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc. Natl Acad. Sci. USA 95, 8847-8851 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 8847-8851
    • De La Coste, A.1    Romagnolo, B.2    Billuart, P.3
  • 80
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of a-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K, Roberts RL, Aderca IN et al. Mutational spectrum of a-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 21(31), 4863-4871 (2002).
    • (2002) Oncogene , vol.21 , Issue.31 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, R.L.2    Aderca, I.N.3
  • 81
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24(3), 245-250 (2000).
    • (2000) Nature Genet. , vol.24 , Issue.3 , pp. 245-250
  • 82
    • 18644373146 scopus 로고    scopus 로고
    • The a-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • Wetering MV, Sancho E, Verweij C et al. The a-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111(2), 241-250 (2002).
    • (2002) Cell , vol.111 , Issue.2 , pp. 241-250
    • Wetering, M.V.1    Sancho, E.2    Verweij, C.3
  • 83
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom OJ, Reed KR, Hayes AJ et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18(12), 1385-1390 (2004).
    • (2004) Genes Dev. , vol.18 , Issue.12 , pp. 1385-1390
    • Sansom, O.J.1    Reed, K.R.2    Hayes, A.J.3
  • 84
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non-small cell lung cancer: Evidence of dishevelled overexpression
    • Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM: Activation of the Wnt pathway in non-small cell lung cancer: evidence of dishevelled overexpression. Oncogene 22, 7218-7221 (2003).
    • (2003) Oncogene , vol.22 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3    Xu, Z.4    McCormick, F.5    Jablons, D.M.6
  • 85
    • 0043092191 scopus 로고    scopus 로고
    • Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of a-catenin
    • Uematsu K, Kanazawa S, You L et al.: Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of a-catenin. Cancer Res. 63, 4547-4551 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 4547-4551
    • Uematsu, K.1    Kanazawa, S.2    You, L.3
  • 86
    • 0038301969 scopus 로고    scopus 로고
    • Amplification, upregulation and overexpression of DVL-1, the human counterpart of the Drosophila |Disheveled gene, in primary breast cancers
    • Nagahata T, Shimada T, Harada A et al.: Amplification, upregulation and overexpression of DVL-1, the human counterpart of the Drosophila |Disheveled gene, in primary breast cancers. Cancer Sci. 94, 515-518 (2003).
    • (2003) Cancer Sci. , vol.94 , pp. 515-518
    • Nagahata, T.1    Shimada, T.2    Harada, A.3
  • 87
    • 0038517899 scopus 로고    scopus 로고
    • A-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    • Zechner D, Fujita Y, Hulsken J et al.: a-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258, 406-418 (2003).
    • (2003) Dev. Biol. , vol.258 , pp. 406-418
    • Zechner, D.1    Fujita, Y.2    Hulsken, J.3
  • 88
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3- specific inhibitor
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3- specific inhibitor. Nature Med. 10, 55-63 (2004).
    • (2004) Nature Med. , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 89
    • 0347359163 scopus 로고    scopus 로고
    • Wnt proteins promote neuronal differentiation in neural stem cell culture
    • Muroyama Y, Kondoh H, Takada S: Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem. Biophys. Res. Commun. 313, 915-921 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.313 , pp. 915-921
    • Muroyama, Y.1    Kondoh, H.2    Takada, S.3
  • 90
    • 0034672241 scopus 로고    scopus 로고
    • WNT signaling modulates the diversification of hematopoietic cells
    • Brandon C, Eisenberg LM, Eisenberg CA: WNT signaling modulates the diversification of hematopoietic cells. Blood 96, 4132-4141 (2000).
    • (2000) Blood , vol.96 , pp. 4132-4141
    • Brandon, C.1    Eisenberg, L.M.2    Eisenberg, C.A.3
  • 91
    • 18744398990 scopus 로고    scopus 로고
    • Apc modulates embryonic stem-cell differentiation by controlling the dosage of a-catenin signaling
    • Kielman MF, Rindapaa M, Gaspar C et al.: Apc modulates embryonic stem-cell differentiation by controlling the dosage of a-catenin signaling. Nature Genet. 32, 594-605 (2002).
    • (2002) Nature Genet. , vol.32 , pp. 594-605
    • Kielman, M.F.1    Rindapaa, M.2    Gaspar, C.3
  • 92
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, Duncan AW, Ailles L et al.: A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409-414 (2003).
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3
  • 93
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoyesis
    • Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R: Role of members of the Wnt gene family in human hematopoyesis. Blood 92(9), 3189-3202. (1998).
    • (1998) Blood , vol.92 , Issue.9 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4
  • 94
    • 1642499734 scopus 로고    scopus 로고
    • A- catenin is dispensable for hematopoiesis and lymphopoiesis
    • Cobas M, Wilson A, Ernst B et al.: a- catenin is dispensable for hematopoiesis and lymphopoiesis. J. Exp. Med. 199(2), 221-229 (2004).
    • (2004) J. Exp. Med. , vol.199 , Issue.2 , pp. 221-229
    • Cobas, M.1    Wilson, A.2    Ernst, B.3
  • 95
    • 0038488949 scopus 로고    scopus 로고
    • Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration
    • Polesskaya A, Seale P, Rudnicki M: Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell 113(7), 841-852 (2003).
    • (2003) Cell , vol.113 , Issue.7 , pp. 841-852
    • Polesskaya, A.1    Seale, P.2    Rudnicki, M.3
  • 96
    • 0034822702 scopus 로고    scopus 로고
    • Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: CDNA array analysis of intrahepatic differential gene expression
    • Shackel NA, McGuinness PH, Abbott CA, Gorrell M D, McCaughan GW: Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut 49(4), 565-576 (2001).
    • (2001) Gut , vol.49 , Issue.4 , pp. 565-576
    • Shackel, N.A.1    McGuinness, P.H.2    Abbott, C.A.3    Gorrell, M.D.4    McCaughan, G.W.5
  • 97
    • 0035032989 scopus 로고    scopus 로고
    • Changes in WNT/a-catenin pathway during regulated growth in rat liver regeneration
    • Monga SP, Pediaditakis P, Mule K, Stolz DB Michalopoulos GK: Changes in WNT/a-catenin pathway during regulated growth in rat liver regeneration. Hepatology 33(5), 1098-1109 (2001).
    • (2001) Hepatology , vol.33 , Issue.5 , pp. 1098-1109
    • Monga, S.P.1    Pediaditakis, P.2    Mule, K.3    Stolz, D.B.4    Michalopoulos, G.K.5
  • 98
    • 0037376219 scopus 로고    scopus 로고
    • CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury
    • Surendran K, Simon T C: CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am.J. Physiol. Renal Physiol. 284(4), 653-662 (2003).
    • (2003) Am.J. Physiol. Renal Physiol. , vol.284 , Issue.4 , pp. 653-662
    • Surendran, K.1    Simon, T.C.2
  • 99
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Wang B et al.: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422(6929), 313-317 (2003).
    • (2003) Nature , vol.422 , Issue.6929 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Wang, B.3
  • 100
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G: Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423(6937), 255-260 (2003).
    • (2003) Nature , vol.423 , Issue.6937 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 101
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Karhadkar S, Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432(7015), 324-331 (2004).
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Karhadkar, S.1    Berman, D.M.2
  • 102
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in selfrenewal capacity
    • Hope KJ, Jin L, Dick JE: Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in selfrenewal capacity. Nature Immunol. 5, 738-743 (2004).
    • (2004) Nature Immunol. , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 103
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730-737, (1997).
    • (1997) Nature Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 104
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X, Curtin J, Xiong Y et al.: Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23, 9392-9400 (2004).
    • (2004) Oncogene , vol.23 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 105
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID et al.: Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 107
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • Bapat SA, Mali AM, Koppikar CB, Kurrey NK: Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 65, 3025-3029 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 3025-3029
    • Bapat, S.A.1    Mali, A.M.2    Koppikar, C.B.3    Kurrey, N.K.4
  • 108
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL: Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17, 3029-3035 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 109
    • 0025992197 scopus 로고
    • Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil
    • Harrison DE, Lerner CP: Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood 78(5), 1237-1240 (1991).
    • (1991) Blood , vol.78 , Issue.5 , pp. 1237-1240
    • Harrison, D.E.1    Lerner, C.P.2
  • 110
    • 0032530301 scopus 로고    scopus 로고
    • Apoptotic regulation in primitive hematopoietic precursors
    • Peters R, Leyvraz S, Perey L: Apoptotic regulation in primitive hematopoietic precursors. Blood 92(6), 2041-2052 (1998).
    • (1998) Blood , vol.92 , Issue.6 , pp. 2041-2052
    • Peters, R.1    Leyvraz, S.2    Perey, L.3
  • 111
    • 0037079708 scopus 로고    scopus 로고
    • The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    • Scharenberg CW, Harkey MA, Torok- Storb B: The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 99(2), 507-512 (2002).
    • (2002) Blood , vol.99 , Issue.2 , pp. 507-512
    • Scharenberg, C.W.1    Harkey, M.A.2    Torok- Storb, B.3
  • 112
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S: Tumour stem cells and drug resistance. Nature Rev.Cancer 5, 275-284 (2005).
    • (2005) Nature Rev.Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 113
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering RNAs directed against a-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma UN, Surabhi RM, Schmaltieg A, Becerra A, Gaynor RB: Small interfering RNAs directed against a-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin. Cancer Res. 9(4), 1291-1300 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.4 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3    Becerra, A.4    Gaynor, R.B.5
  • 114
    • 0035825119 scopus 로고    scopus 로고
    • Wnt-1 signaling inhibits apoptosis by activating a-catenin/T cell factor-mediated transcription
    • Chen S, Guttridge DC, You Z et al.: Wnt-1 signaling inhibits apoptosis by activating a-catenin/T cell factor-mediated transcription. J. Cell Biol. 152, 87-96 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 87-96
    • Chen, S.1    Guttridge, D.C.2    You, Z.3
  • 115
    • 3442894128 scopus 로고    scopus 로고
    • An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
    • You L, He B, Xu Z et al.: An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res. 64, 5385-5389 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 5385-5389
    • You, L.1    He, B.2    Xu, Z.3
  • 116
    • 25444496522 scopus 로고    scopus 로고
    • Wnt2 as a new therapeutic target in malignant pleural mesothelioma
    • Mazieres J, You L, He B et al.: Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int. J. Cancer 117(2), 326-332 (2005).
    • (2005) Int. J. Cancer , vol.117 , Issue.2 , pp. 326-332
    • Mazieres, J.1    You, L.2    He, B.3
  • 117
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic Tcf/a-catenin protein complex
    • Lepourcelet M, Chen Y, France D et al.: Small-molecule antagonists of the oncogenic Tcf/a-catenin protein complex. Cancer Cell 5(1), 91-102 (2004).
    • (2004) Cancer Cell , vol.5 , Issue.1 , pp. 91-102
    • Lepourcelet, M.1    Chen, Y.2    France, D.3
  • 118
    • 4344587136 scopus 로고    scopus 로고
    • A small molecule inhibitor of betacatenin/ CREB-binding protein transcription
    • Emami KY, Nguyen C, Ma AH et al.: A small molecule inhibitor of betacatenin/ CREB-binding protein transcription. Proc. Natl Acad. Sci. USA 101(34), 12682-12687 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.34 , pp. 12682-12687
    • Emami, K.Y.1    Nguyen, C.2    Ma, A.H.3
  • 119
    • 18244400410 scopus 로고    scopus 로고
    • Functional genomic analysis of the Wnt-Wingless signaling pathway
    • Dasgupta R, Kaykas A, Moon RT, Perrimon N: Functional genomic analysis of the Wnt-Wingless signaling pathway. Science 308, 826-833 (2005).
    • (2005) Science , vol.308 , pp. 826-833
    • Dasgupta, R.1    Kaykas, A.2    Moon, R.T.3    Perrimon, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.