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Volumn 16, Issue 10, 2005, Pages 4572-4583

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP RECEPTOR; G PROTEIN COUPLED RECEPTOR; PROTEIN AVO1; PROTEIN AVO3; PROTEIN CAR1; PROTEIN KINASE B; PROTEIN LST8; PROTEIN PIA; PROTEIN PKBR1; PROTEIN RIP3; TARGET OF RAPAMYCIN COMPLEX 2; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

EID: 26244438381     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-04-0342     Document Type: Article
Times cited : (171)

References (45)
  • 2
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269.
    • (1997) Curr. Biol. , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 3
    • 0033279835 scopus 로고    scopus 로고
    • Integration of signaling networks that regulate Dictyostelium differentiation
    • Aubry, L., and Firtel, R. (1999). Integration of signaling networks that regulate Dictyostelium differentiation. Annu. Rev. Cell Dev. Biol. 15, 469-517.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 469-517
    • Aubry, L.1    Firtel, R.2
  • 4
    • 0030722988 scopus 로고    scopus 로고
    • A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium
    • Chen, M. Y., Long, Y., and Devreotes, P. N. (1997). A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 11, 3218-3231.
    • (1997) Genes Dev. , vol.11 , pp. 3218-3231
    • Chen, M.Y.1    Long, Y.2    Devreotes, P.N.3
  • 5
    • 0035947085 scopus 로고    scopus 로고
    • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
    • Chung, C. Y., Potikyan, G., and Firtel, R. A. (2001). Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937-947.
    • (2001) Mol. Cell , vol.7 , pp. 937-947
    • Chung, C.Y.1    Potikyan, G.2    Firtel, R.A.3
  • 6
    • 12544249887 scopus 로고    scopus 로고
    • The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis
    • Comer, F. I., Lippincott, C. K., Masbad, J. J., and Parent, C. A. (2005). The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr. Biol. 15, 134-139.
    • (2005) Curr. Biol. , vol.15 , pp. 134-139
    • Comer, F.I.1    Lippincott, C.K.2    Masbad, J.J.3    Parent, C.A.4
  • 7
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • Funamoto, S., Meili, R., Lee, S., Parry, L., and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 8
    • 0035858886 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
    • Funamoto, S., Milan, K., Meili, R., and Firtel, R. A. (2001). Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153, 795-809.
    • (2001) J. Cell Biol. , vol.153 , pp. 795-809
    • Funamoto, S.1    Milan, K.2    Meili, R.3    Firtel, R.A.4
  • 9
    • 0024044667 scopus 로고
    • Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells
    • Hall, A. L., Schlein, A., and Condeelis, J. (1988). Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells. J. Cell. Biochem. 37, 285-299.
    • (1988) J. Cell. Biochem. , vol.37 , pp. 285-299
    • Hall, A.L.1    Schlein, A.2    Condeelis, J.3
  • 10
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N., and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 11
    • 0028093610 scopus 로고
    • CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
    • Insall, R., Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F., and Devreotes, P. (1994). CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545.
    • (1994) J. Cell Biol. , vol.126 , pp. 1537-1545
    • Insall, R.1    Kuspa, A.2    Lilly, P.J.3    Shaulsky, G.4    Levin, L.R.5    Loomis, W.F.6    Devreotes, P.7
  • 12
    • 0030156329 scopus 로고    scopus 로고
    • The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
    • Insall, R. H., Borleis, J., and Devreotes, P. N. (1996). The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr. Biol. 6, 719-729.
    • (1996) Curr. Biol. , vol.6 , pp. 719-729
    • Insall, R.H.1    Borleis, J.2    Devreotes, P.N.3
  • 13
    • 0037312507 scopus 로고    scopus 로고
    • Tor signalling in bugs, brain and brawn
    • Jacinto, E., and Hall, M. N. (2003). Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell. Biol. 4, 117-126.
    • (2003) Nat. Rev. Mol. Cell. Biol. , vol.4 , pp. 117-126
    • Jacinto, E.1    Hall, M.N.2
  • 14
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., Hall, A., and Hall, M. N. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 16
    • 0037459060 scopus 로고    scopus 로고
    • Adenylyl cyclase localization regulates streaming during chemotaxis
    • Kriebel, P. W., Barr, V. A., and Parent, C. A. (2003). Adenylyl cyclase localization regulates streaming during chemotaxis. Cell 112, 549-560.
    • (2003) Cell , vol.112 , pp. 549-560
    • Kriebel, P.W.1    Barr, V.A.2    Parent, C.A.3
  • 17
    • 0035168658 scopus 로고    scopus 로고
    • Under-agarose folate chemotaxis of Dictyostelium discoideum amoebae in permissive and mechanically inhibited conditions
    • Laevsky, G., and Knecht, D. A. (2001). Under-agarose folate chemotaxis of Dictyostelium discoideum amoebae in permissive and mechanically inhibited conditions. Biotechniques 31, 1140-1149.
    • (2001) Biotechniques , vol.31 , pp. 1140-1149
    • Laevsky, G.1    Knecht, D.A.2
  • 18
    • 0032849043 scopus 로고    scopus 로고
    • A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
    • Lee, S., Parent, C. A., Insall, R., and Firtel, R. A. (1999). A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell 10, 2829-2845.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2829-2845
    • Lee, S.1    Parent, C.A.2    Insall, R.3    Firtel, R.A.4
  • 20
    • 0028978605 scopus 로고
    • Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
    • Lilly, P. J., and Devreotes, P. N. (1995). Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129, 1659-1665.
    • (1995) J. Cell Biol. , vol.129 , pp. 1659-1665
    • Lilly, P.J.1    Devreotes, P.N.2
  • 23
    • 0034659225 scopus 로고    scopus 로고
    • A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium
    • Meili, R., Ellsworth, C., and Firtel, R. A. (2000). A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10, 708-717.
    • (2000) Curr. Biol. , vol.10 , pp. 708-717
    • Meili, R.1    Ellsworth, C.2    Firtel, R.A.3
  • 24
    • 0033560747 scopus 로고    scopus 로고
    • Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
    • Meili, R., Ellsworth, C., Lee, S., Reddy, T., Ma, H., and Firtel, R. (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18, 2092-2105.
    • (1999) EMBO J. , vol.18 , pp. 2092-2105
    • Meili, R.1    Ellsworth, C.2    Lee, S.3    Reddy, T.4    Ma, H.5    Firtel, R.6
  • 25
    • 0041327718 scopus 로고    scopus 로고
    • Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways
    • Merlot, S., and Firtel, R. A. (2003). Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116, 3471-3478.
    • (2003) J. Cell Sci. , vol.116 , pp. 3471-3478
    • Merlot, S.1    Firtel, R.A.2
  • 26
    • 0032475863 scopus 로고    scopus 로고
    • G protein signaling events are activated at the leading edge of chemotactic cells
    • Parent, C., Blacklock, B., Froehlich, W., Murphy, D., and Devreotes, P. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
    • (1998) Cell , vol.95 , pp. 81-91
    • Parent, C.1    Blacklock, B.2    Froehlich, W.3    Murphy, D.4    Devreotes, P.5
  • 27
    • 0029088825 scopus 로고
    • Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis
    • Parent, C. A., and Devreotes, P. N. (1995). Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270, 22693-22696.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22693-22696
    • Parent, C.A.1    Devreotes, P.N.2
  • 28
    • 0029943450 scopus 로고    scopus 로고
    • Molecular genetics of signal transduction in Dictyostelium
    • Parent, C. A., and Devreotes, P. N. (1996). Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65, 411-440.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 411-440
    • Parent, C.A.1    Devreotes, P.N.2
  • 29
    • 8444247968 scopus 로고    scopus 로고
    • Rac regulation of chemotaxis and morphogenesis in Dictyostelium
    • Park, K. C., Rivero, F., Meili, R., Lee, S., Apone, F., and Firtel, R. A. (2004). Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J. 23, 4177-4189.
    • (2004) EMBO J. , vol.23 , pp. 4177-4189
    • Park, K.C.1    Rivero, F.2    Meili, R.3    Lee, S.4    Apone, F.5    Firtel, R.A.6
  • 31
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabarini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabarini, D.M.4
  • 32
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov dos, D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabarini, D. M. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov Dos, D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabarini, D.M.8
  • 33
    • 8444221934 scopus 로고    scopus 로고
    • Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
    • Sasaki, A. T., Chun, C., Takeda, K., and Firtel, R. A. (2004). Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J. Cell Biol. 167, 505-518.
    • (2004) J. Cell Biol. , vol.167 , pp. 505-518
    • Sasaki, A.T.1    Chun, C.2    Takeda, K.3    Firtel, R.A.4
  • 34
    • 0030906569 scopus 로고    scopus 로고
    • The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    • Schmidt, A., Bickle, M., Beck, T., and Hall, M. N. (1997). The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88, 531-542.
    • (1997) Cell , vol.88 , pp. 531-542
    • Schmidt, A.1    Bickle, M.2    Beck, T.3    Hall, M.N.4
  • 35
    • 0030479340 scopus 로고    scopus 로고
    • TOR2 is required for organization of the actin cytoskeleton in yeast
    • Schmidt, A., Kunz, J., and Hall, M. N. (1996). TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl. Acad. Sci. USA 93, 13780-13785.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13780-13785
    • Schmidt, A.1    Kunz, J.2    Hall, M.N.3
  • 37
    • 0036532121 scopus 로고    scopus 로고
    • Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
    • Stephens, L., Ellson, C., and Hawkins, P. (2002). Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14, 203-213.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 203-213
    • Stephens, L.1    Ellson, C.2    Hawkins, P.3
  • 38
    • 0027217068 scopus 로고
    • A transformation vector for Dictyostelium discoideum with a new selectable marker bsr
    • Sutoh, K. (1993). A transformation vector for Dictyostelium discoideum with a new selectable marker bsr. Plasmid 30, 150-154.
    • (1993) Plasmid , vol.30 , pp. 150-154
    • Sutoh, K.1
  • 41
    • 0035106351 scopus 로고    scopus 로고
    • Large-scale analysis of the yeast proteome by multidimensional protein identification technology
    • Washburn, M. P., Wolters, D., and Yates, J. R., III (2001). Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242-247.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 242-247
    • Washburn, M.P.1    Wolters, D.2    Yates III, J.R.3
  • 43
    • 0023924075 scopus 로고
    • Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain
    • Wessels, D., Soll, D. R., Knecht, D., Loomis, W. F., De Lozanne, A., and Spudich, J. (1988). Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain. Dev. Biol. 128, 164-177.
    • (1988) Dev. Biol. , vol.128 , pp. 164-177
    • Wessels, D.1    Soll, D.R.2    Knecht, D.3    Loomis, W.F.4    De Lozanne, A.5    Spudich, J.6
  • 44
    • 0032462246 scopus 로고    scopus 로고
    • A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells
    • Wessels, D., Voss, E., Von Bergen, N., Burns, R., Stites, J., and Soll, D. R. (1998). A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells. Cell Motil. Cytoskelet. 41, 225-246.
    • (1998) Cell Motil. Cytoskelet. , vol.41 , pp. 225-246
    • Wessels, D.1    Voss, E.2    Von Bergen, N.3    Burns, R.4    Stites, J.5    Soll, D.R.6
  • 45
    • 0034176579 scopus 로고    scopus 로고
    • The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    • Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., and Alessi, D. R. (2000). The role of 3-phosphoinositide- dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10, 439-448.
    • (2000) Curr. Biol. , vol.10 , pp. 439-448
    • Williams, M.R.1    Arthur, J.S.2    Balendran, A.3    Van Der Kaay, J.4    Poli, V.5    Cohen, P.6    Alessi, D.R.7


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