-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551.
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269.
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
3
-
-
0033279835
-
Integration of signaling networks that regulate Dictyostelium differentiation
-
Aubry, L., and Firtel, R. (1999). Integration of signaling networks that regulate Dictyostelium differentiation. Annu. Rev. Cell Dev. Biol. 15, 469-517.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 469-517
-
-
Aubry, L.1
Firtel, R.2
-
4
-
-
0030722988
-
A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium
-
Chen, M. Y., Long, Y., and Devreotes, P. N. (1997). A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 11, 3218-3231.
-
(1997)
Genes Dev.
, vol.11
, pp. 3218-3231
-
-
Chen, M.Y.1
Long, Y.2
Devreotes, P.N.3
-
5
-
-
0035947085
-
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
-
Chung, C. Y., Potikyan, G., and Firtel, R. A. (2001). Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937-947.
-
(2001)
Mol. Cell
, vol.7
, pp. 937-947
-
-
Chung, C.Y.1
Potikyan, G.2
Firtel, R.A.3
-
6
-
-
12544249887
-
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis
-
Comer, F. I., Lippincott, C. K., Masbad, J. J., and Parent, C. A. (2005). The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr. Biol. 15, 134-139.
-
(2005)
Curr. Biol.
, vol.15
, pp. 134-139
-
-
Comer, F.I.1
Lippincott, C.K.2
Masbad, J.J.3
Parent, C.A.4
-
7
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
Funamoto, S., Meili, R., Lee, S., Parry, L., and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Parry, L.4
Firtel, R.A.5
-
8
-
-
0035858886
-
Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
-
Funamoto, S., Milan, K., Meili, R., and Firtel, R. A. (2001). Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153, 795-809.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 795-809
-
-
Funamoto, S.1
Milan, K.2
Meili, R.3
Firtel, R.A.4
-
9
-
-
0024044667
-
Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells
-
Hall, A. L., Schlein, A., and Condeelis, J. (1988). Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells. J. Cell. Biochem. 37, 285-299.
-
(1988)
J. Cell. Biochem.
, vol.37
, pp. 285-299
-
-
Hall, A.L.1
Schlein, A.2
Condeelis, J.3
-
10
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N., and Sonenberg, N. (2004). Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
11
-
-
0028093610
-
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
-
Insall, R., Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F., and Devreotes, P. (1994). CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545.
-
(1994)
J. Cell Biol.
, vol.126
, pp. 1537-1545
-
-
Insall, R.1
Kuspa, A.2
Lilly, P.J.3
Shaulsky, G.4
Levin, L.R.5
Loomis, W.F.6
Devreotes, P.7
-
12
-
-
0030156329
-
The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
-
Insall, R. H., Borleis, J., and Devreotes, P. N. (1996). The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr. Biol. 6, 719-729.
-
(1996)
Curr. Biol.
, vol.6
, pp. 719-729
-
-
Insall, R.H.1
Borleis, J.2
Devreotes, P.N.3
-
13
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto, E., and Hall, M. N. (2003). Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell. Biol. 4, 117-126.
-
(2003)
Nat. Rev. Mol. Cell. Biol.
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
14
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., Hall, A., and Hall, M. N. (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
16
-
-
0037459060
-
Adenylyl cyclase localization regulates streaming during chemotaxis
-
Kriebel, P. W., Barr, V. A., and Parent, C. A. (2003). Adenylyl cyclase localization regulates streaming during chemotaxis. Cell 112, 549-560.
-
(2003)
Cell
, vol.112
, pp. 549-560
-
-
Kriebel, P.W.1
Barr, V.A.2
Parent, C.A.3
-
17
-
-
0035168658
-
Under-agarose folate chemotaxis of Dictyostelium discoideum amoebae in permissive and mechanically inhibited conditions
-
Laevsky, G., and Knecht, D. A. (2001). Under-agarose folate chemotaxis of Dictyostelium discoideum amoebae in permissive and mechanically inhibited conditions. Biotechniques 31, 1140-1149.
-
(2001)
Biotechniques
, vol.31
, pp. 1140-1149
-
-
Laevsky, G.1
Knecht, D.A.2
-
18
-
-
0032849043
-
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
-
Lee, S., Parent, C. A., Insall, R., and Firtel, R. A. (1999). A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell 10, 2829-2845.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 2829-2845
-
-
Lee, S.1
Parent, C.A.2
Insall, R.3
Firtel, R.A.4
-
19
-
-
9444297930
-
Dictyostelium PAKc is required for proper chemotaxis
-
Lee, S., Rivero, F., Park, K. C., Huang, E., Funamoto, S., and Firtel, R. A. (2004). Dictyostelium PAKc is required for proper chemotaxis. Mol. Biol. Cell 15, 5456-5469.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 5456-5469
-
-
Lee, S.1
Rivero, F.2
Park, K.C.3
Huang, E.4
Funamoto, S.5
Firtel, R.A.6
-
20
-
-
0028978605
-
Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
-
Lilly, P. J., and Devreotes, P. N. (1995). Chemoattractant and GTP gamma S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129, 1659-1665.
-
(1995)
J. Cell Biol.
, vol.129
, pp. 1659-1665
-
-
Lilly, P.J.1
Devreotes, P.N.2
-
21
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M. N. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
23
-
-
0034659225
-
A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium
-
Meili, R., Ellsworth, C., and Firtel, R. A. (2000). A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10, 708-717.
-
(2000)
Curr. Biol.
, vol.10
, pp. 708-717
-
-
Meili, R.1
Ellsworth, C.2
Firtel, R.A.3
-
24
-
-
0033560747
-
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
-
Meili, R., Ellsworth, C., Lee, S., Reddy, T., Ma, H., and Firtel, R. (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18, 2092-2105.
-
(1999)
EMBO J.
, vol.18
, pp. 2092-2105
-
-
Meili, R.1
Ellsworth, C.2
Lee, S.3
Reddy, T.4
Ma, H.5
Firtel, R.6
-
25
-
-
0041327718
-
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways
-
Merlot, S., and Firtel, R. A. (2003). Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116, 3471-3478.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 3471-3478
-
-
Merlot, S.1
Firtel, R.A.2
-
26
-
-
0032475863
-
G protein signaling events are activated at the leading edge of chemotactic cells
-
Parent, C., Blacklock, B., Froehlich, W., Murphy, D., and Devreotes, P. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
-
(1998)
Cell
, vol.95
, pp. 81-91
-
-
Parent, C.1
Blacklock, B.2
Froehlich, W.3
Murphy, D.4
Devreotes, P.5
-
27
-
-
0029088825
-
Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis
-
Parent, C. A., and Devreotes, P. N. (1995). Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270, 22693-22696.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22693-22696
-
-
Parent, C.A.1
Devreotes, P.N.2
-
28
-
-
0029943450
-
Molecular genetics of signal transduction in Dictyostelium
-
Parent, C. A., and Devreotes, P. N. (1996). Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65, 411-440.
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 411-440
-
-
Parent, C.A.1
Devreotes, P.N.2
-
29
-
-
8444247968
-
Rac regulation of chemotaxis and morphogenesis in Dictyostelium
-
Park, K. C., Rivero, F., Meili, R., Lee, S., Apone, F., and Firtel, R. A. (2004). Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J. 23, 4177-4189.
-
(2004)
EMBO J.
, vol.23
, pp. 4177-4189
-
-
Park, K.C.1
Rivero, F.2
Meili, R.3
Lee, S.4
Apone, F.5
Firtel, R.A.6
-
30
-
-
0344305784
-
Cell migration: Integrating signals from front to back
-
Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T., and Horwitz, A. R. (2003). Cell migration: integrating signals from front to back. Science 302, 1704-1709.
-
(2003)
Science
, vol.302
, pp. 1704-1709
-
-
Ridley, A.J.1
Schwartz, M.A.2
Burridge, K.3
Firtel, R.A.4
Ginsberg, M.H.5
Borisy, G.6
Parsons, J.T.7
Horwitz, A.R.8
-
31
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabarini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabarini, D.M.4
-
32
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov dos, D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabarini, D. M. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov Dos, D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabarini, D.M.8
-
33
-
-
8444221934
-
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
-
Sasaki, A. T., Chun, C., Takeda, K., and Firtel, R. A. (2004). Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J. Cell Biol. 167, 505-518.
-
(2004)
J. Cell Biol.
, vol.167
, pp. 505-518
-
-
Sasaki, A.T.1
Chun, C.2
Takeda, K.3
Firtel, R.A.4
-
34
-
-
0030906569
-
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
-
Schmidt, A., Bickle, M., Beck, T., and Hall, M. N. (1997). The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88, 531-542.
-
(1997)
Cell
, vol.88
, pp. 531-542
-
-
Schmidt, A.1
Bickle, M.2
Beck, T.3
Hall, M.N.4
-
35
-
-
0030479340
-
TOR2 is required for organization of the actin cytoskeleton in yeast
-
Schmidt, A., Kunz, J., and Hall, M. N. (1996). TOR2 is required for organization of the actin cytoskeleton in yeast. Proc. Natl. Acad. Sci. USA 93, 13780-13785.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13780-13785
-
-
Schmidt, A.1
Kunz, J.2
Hall, M.N.3
-
36
-
-
0035337319
-
Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium
-
Steimle, P. A., Yumura, S., Cote, G. P., Medley, Q. G., Polyakov, M. V., Leppert, B., and Egelhoff, T. T. (2001). Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium. Curr. Biol. 11, 708-713.
-
(2001)
Curr. Biol.
, vol.11
, pp. 708-713
-
-
Steimle, P.A.1
Yumura, S.2
Cote, G.P.3
Medley, Q.G.4
Polyakov, M.V.5
Leppert, B.6
Egelhoff, T.T.7
-
37
-
-
0036532121
-
Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
-
Stephens, L., Ellson, C., and Hawkins, P. (2002). Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14, 203-213.
-
(2002)
Curr. Opin. Cell Biol.
, vol.14
, pp. 203-213
-
-
Stephens, L.1
Ellson, C.2
Hawkins, P.3
-
38
-
-
0027217068
-
A transformation vector for Dictyostelium discoideum with a new selectable marker bsr
-
Sutoh, K. (1993). A transformation vector for Dictyostelium discoideum with a new selectable marker bsr. Plasmid 30, 150-154.
-
(1993)
Plasmid
, vol.30
, pp. 150-154
-
-
Sutoh, K.1
-
39
-
-
0030838576
-
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth
-
Tuxworth, R. I., Cheetham, J. L., Machesky, L. M., Spiegelmann, G. B., Weeks, G., and Insall, R. H. (1997). Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. J. Cell Biol. 138, 605-614.
-
(1997)
J. Cell Biol.
, vol.138
, pp. 605-614
-
-
Tuxworth, R.I.1
Cheetham, J.L.2
Machesky, L.M.3
Spiegelmann, G.B.4
Weeks, G.5
Insall, R.H.6
-
41
-
-
0035106351
-
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
-
Washburn, M. P., Wolters, D., and Yates, J. R., III (2001). Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242-247.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 242-247
-
-
Washburn, M.P.1
Wolters, D.2
Yates III, J.R.3
-
42
-
-
0036308972
-
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
-
Weiner, O. D., Neilsen, P. O., Prestwich, G. D., Kirschner, M. W., Cantley, L. C., and Bourne, H. R. (2002). A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4, 509-513.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 509-513
-
-
Weiner, O.D.1
Neilsen, P.O.2
Prestwich, G.D.3
Kirschner, M.W.4
Cantley, L.C.5
Bourne, H.R.6
-
43
-
-
0023924075
-
Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain
-
Wessels, D., Soll, D. R., Knecht, D., Loomis, W. F., De Lozanne, A., and Spudich, J. (1988). Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain. Dev. Biol. 128, 164-177.
-
(1988)
Dev. Biol.
, vol.128
, pp. 164-177
-
-
Wessels, D.1
Soll, D.R.2
Knecht, D.3
Loomis, W.F.4
De Lozanne, A.5
Spudich, J.6
-
44
-
-
0032462246
-
A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells
-
Wessels, D., Voss, E., Von Bergen, N., Burns, R., Stites, J., and Soll, D. R. (1998). A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells. Cell Motil. Cytoskelet. 41, 225-246.
-
(1998)
Cell Motil. Cytoskelet.
, vol.41
, pp. 225-246
-
-
Wessels, D.1
Voss, E.2
Von Bergen, N.3
Burns, R.4
Stites, J.5
Soll, D.R.6
-
45
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., and Alessi, D. R. (2000). The role of 3-phosphoinositide- dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10, 439-448.
-
(2000)
Curr. Biol.
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
Van Der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
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