Targeted drug delivery to the respiratory tract: Solute permeability of air-interface cultured rabbit tracheal epithelial cell monolayers

Journal of Drug Targeting

Volumn 4, Issue 2, 1996, Pages 79-86

  Mathias, Neil R ^a   Kim, Kwang Jin ^a   Lee, Vincent H L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Air interfaced culture; Equivalent pore radius; FITC dextrans; Lipophilicity; Permeability; Rabbit tracheal epithelium; adrenergic compounds

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETAXOLOL; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; METOPROLOL TARTRATE; PROPRANOLOL; SALBUTAMOL; SALBUTAMOL SULFATE; TIMOLOL MALEATE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG TARGETING; DRUG TRANSPORT; EPITHELIUM CELL; EXPERIMENTAL MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; MOLECULAR WEIGHT; MONOLAYER CULTURE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RESPIRATORY SYSTEM; TRACHEA MUCOSA;

EID: 0029823014     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869609046265     Document Type: Article

References (32)

1. Al-Bazzaz, F.J. (1986) Regulation of salt and water transport across airway mucosa. Clin. Chest Med., 7, 259-272.
2. Artursson, P. (1990) Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci., 79, 476-482.
3. Audus, K.L., Bartel, R.L., Hidalgo, I.J. and Borchardt, R.T. (1990) The use of cultured epithelial and endothelial cells for drug transport and metabolism studies. Pharm. Res., 7, 435-450.
4. Clancy, R.L. and Cripps, A.W. (1990) The handling of inhaled antigen within the respiratory tract. Adv. Drug Deliv. Rev., 5, 63-72.
5. Corbo, D.C, Liu, J.E. and Chien, Y.W. (1990) characterization of the barrier properties of mucosal membranes. J Pharm. Sci., 79, 202-206.
6. Durbin, R.P., Frank, H. and Solomon, A.K. (1956) Water flow through frog gastric mucosa. J. Gen. Physiol., 39, 531-535.
7. Enna, S.J. and Schanker, L.S. (1972) Absorption of drugs from the rat lung. Am. J. Physiol., 223, 1227-1231.
8. French, M.C. and Wishart, G.N. (1985) Isolated perfused rabbit lung as a model to study the absorption of organic aerosols. J. Pharmacol. Methods, 13, 241-248.
9. Guo, Y., Schneider, L.A. and Wangensteen, O.D. (1995) HOCl effects on tracheal epithelium: conductance and permeability measurements. J. Appl Physiol., 78, 1330-1338.
10. Hoogstrate, A.J., Cullander, C., Nagelkerke, J.F., Senel, S., Verhoef, J.C., Junginger, H.E. and Bodde, H.E. (1994) Diffusion rates and transport pathways of fluorescein isothiocyanate (FITC)-labeled model compounds through buccal epithelium. Pharm. Res., 11, 83-89.
11. Jarnigan, F., Davis, J.D., Bromberg, P.A., Gatzy, J.T. and Boucher, R.C. (1983) Bioelectric properties and ion transport of excised rabbit trachea. J. Appl. Physiol., 55, 1884-1892.
12. Kim, K.J. and Crandall, E.D. (1983) Heteropore populations of bullfrog alveolar epithelium. J. Appl. Physiol., 54, 140-146.
13. Kubo, H., Hosoya, K., Natsume, H., Sugibayashi, K. and Morimoto, Y. (1994) In vitro permeation of various model drugs across rabbit nasal mucosa. Int. J. Pharm., 103, 27-36.
14. Landis, E.M. and Pappenheimer, J.R. (1963) Exchange of substances through the capillary walls. In Hamilton, W.F. and Dow, P. (ed), Handbook of physiology: Circulation, Section 2, Volume 2 (Washington D C.: American Physiology Society), pp 961-1034.
15. Lanman, R.C., Gillilan, R.M. and Schanker, L.S. (1973) Absorption of cardiac glycosides from the respiratory tract. J. Pharmacol. Exp. Ther., 187, 105-111.
16. Marriott, C. (1990) Mucus and mucociliary clearance in the respiratory tract. Adv. Drug Deliv. Rev., 5, 19-35.
17. Mathias, N.R., Robison, T.W., Kim, K.J. and Lee, V.H.L. (1995) Development and characterization of rabbit tracheal epithelial cell culture models for drug transport studies. Pharm. Res., 12, 1499-1505.
18. Matsukawa, Y., Yamahara, H., Lee, V.H.L., Crandall, E.D. and Kim, K.J. (1994) Fluxes of horseradish peroxidase and dextrans across rat alveolar epithelial cell monolayers. Pharm. Res., 11, S-255.
19. McNamee, J. (1982) Restricted dextran transport in the sheep lung lymph preparation. J. Appl. Physiol., 52, 585-590.
20. Morimoto, K., Yamahara, H., Lee, V.H.L. and Kim, K.J. (1993) Dipeptide transport across rat alveolar epithelial cell monolayers. Pharm. Res., 10, 1668-1674.
21. Morimoto, K., Yamahara, H., Lee, V.H.L. and Kim, K.J. (1994) Transport of thyrotropin releasing hormone across rat alveolar epithelial cell monolayers. Life Sci., 54, 2083-2092.
22. Narawane, M., Podder, S.K., Bundgaard, H. and Lee, V.H.L. (1992) Segmental differences in drug permeability, esterase activity and ketone reductase activity in the albino rabbit intestine. J. Drug Targeting, 1, 7-17.
23. Raeburn, D., Underwood, S.L. and Villamil, M.E. (1992) Techniques of drug delivery to the airways, and the assessment of lung function in animal models. J. Pharmacol. Toxicol. Methods, 27, 143-159.
24. Renkin, E.M. (1954) Filtration, diffusion and molecular sieving through porous cellulose membranes. J. Gen. Physiol., 38, 225-243.
25. Saha, P., Yamahara, H., Kim, K.J., Crandall, E.D. and Lee, V.H.L. (1994) Influence of lipophilicity on β-blocker transport across rat alveolar epithelial cell layers. J. Contr. Rel., 32, 191-200.
26. Schanker, L.S. (1978) Drug absorption from the lung. Biochem. Pharmacol., 27, 381-385.
27. Schoenwald, R.D. and Huang, H.S. (1983) Corneal penetration behavior of beta blocking agents I: Physicochemical factors. J. Pharm. Sci., 72, 1266-1272.
28. Shi, B. and Tien, H.T. (1986) Action of calcium channel and beta-adrenergic blocking agents in the bilayer lipid membranes. Biochim. Biophys, Acta, 859, 125-134.
29. Tavakoli-Saberi, M.R. and Audus, K.L. (1989) Physicochemical factors affecting beta-adrenergic antagonist permeation across cultured hamster pouch buccal epithelium. Int. J. Pharm., 56, 135-142.
30. van Bree, J.B., de Boer, A.G., Danhof, M., Ginsel, L.A. and Breimer, D.D. (1988) Characterization of an "in vitro" blood-brain barrier: Effects of molecular size and lipophilicity on the cerebrovascular endothelial transport rates of drugs. J. Pharmacol Exp. Ther., 247, 1233-1239.
31. Wang, W., Sasaki, H., Chien, D.S. and Lee, V.H.L. (1991) Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: a comparison with corneal penetration. Curr. Eye Res., 10, 571-579.
32. Wangensteen, O.D., Schneider, L.A., Fahrenkrug, S.C., Brottman, G.M. and Maynard, R.C. (1993) Tracheal epithelial permeability to nonelectrolytes: species difference. J. Appl. Physiol., 75, 1009-1018.