The pharmacokinetics of pulmonary insulin in the in vitro isolated perfused rat lung: Implications of metabolism and regional deposition

European Journal of Pharmaceutical Sciences

Volumn 25, Issue 4-5, 2005, Pages 369-378

  Pang, Yinuo ^a   Sakagami, Masahiro ^a   Byron, Peter R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Absorption; Deposition; Insulin; Lung; Metabolism; Mucociliary clearance; Pharmacokinetics

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BACITRACIN; DRUG METABOLIZING ENZYME; HUMAN INSULIN; INSULINASE; N ETHYLMALEIMIDE; PEPTIDASE;

ABSORPTION; AIRWAY; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG INSTILLATION; DRUG METABOLISM; KINETICS; LUNG PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ABSORPTION; ANIMALS; BACITRACIN; BIOLOGICAL AVAILABILITY; BRONCHI; DIFFUSION; ENZYME INHIBITORS; FLUORESCEIN-5-ISOTHIOCYANATE; INSTILLATION, DRUG; INSULIN; LUNG; MALE; MODELS, BIOLOGICAL; MUCOCILIARY CLEARANCE; PERFUSION; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; TRACHEA;

EID: 20744447382     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.03.010     Document Type: Article

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