Biochemical evidence for transcytotic absorption of polyaspartamide from the rat lung: Effects of temperature and metabolic inhibitors

Journal of Pharmaceutical Sciences

Volumn 91, Issue 9, 2002, Pages 1958-1968

  Sakagami, Masahiro ^a   Byron, Peter R ^a   Rypacek, Frantisek ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Absorption mechanism; Inhibitors; Isolated rat lung; Kinetic modeling; Macromolecules; Mucociliary clearance; Pulmonary absorption

Indexed keywords

2,4 DINITROPHENOL; MONENSIN; NOCODAZOLE; OUABAIN; POLYHYDROXYETHYLASPARTAMIDE; POLYPEPTIDE; UNCLASSIFIED DRUG;

ABSORPTION; AIRWAY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ISOLATED LUNG; KINETICS; LUNG; MACROMOLECULE; MALE; METABOLIC INHIBITION; MUCOCILIARY CLEARANCE; NONHUMAN; RAT; TEMPERATURE SENSITIVITY; TRANSCYTOSIS;

EID: 0036771091     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10188     Document Type: Article

References (48)

1. Byron PR, Patton JS. 1994. Drug delivery via the respiratory tract. J Aerosol Med 7:49-75.
2. Patton JS. 1996. Mechanisms of macromolecule absorption by the lungs. Adv Drug Del Rev 19:3-36.
3. Folkesson HG, Matthay MA, Westron BR, Kim KJ, Karlsson BW, Hastings RH. 1996. Alveolar epithelial clearance of protein. J Appl Physiol 80:1431-1445.
4. Sakagami M, Byron PR, Venitz J, Rypacek F. 2002. Solute disposition in the rat lung in vivo and in vitro: Determining regional absorption kinetics in the presence of mucociliary escalator. J Pharm Sci 91:594-604.
5. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA. 1994. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol 266:L544-L552.
6. Sweeney TD, Marian M, Achilles K, Bussiere J, Ruppel J, Shoenhoff M, Mrsny RJ. 2000. Biopharmaceutics of immunoglobulin transport across lung epithelium. In: Dalby RN, Byron PR, Farr SJ, Peart J, editors. Respiratory drug delivery VII. Raleigh, NC: Serentec Press, Inc. pp 59-65.
7. Matsukawa Y, Yamahara H, Lee VHL, Crandall ED, Kim KJ. 1996. Horseradish peroxidase transport across rat alveolar epithelial cell monolayers. Pharm Res 13:1331-1335.
8. Niven RW, Rypacek F, Byron PR. 1990. Solute absorption from the airways of the isolated rat lung. III. Absorption of several peptidase-resistant synthetic polypeptides: poly-2-(hydroxyethyl)-aspartamides. Pharm Res 7:990-994.
9. Byron PR, Katayama H, Sun Z, Rypacek F. 1991. Airway retention and pulmonary absorption of polyα,β-[N(2-hydroxyethyl)-D,L-aspartamide]. J Biol Comp Polym 6:25-35.
10. Byron PR, Sun Z, Katayama H, Rypacek F. 1994. Solute absorption from the airways of the isolated rat lung. IV. Mechanisms of absorption of fluorophore-labeled poly-α,β-[N(2-hydroxyethyl)DL-aspartamide]. Pharm Res 11:221-225.
11. Sun JZ, Byron PR, Rypacek F. 1999. Solute absorption from the airways of the isolated rat lung. V. Charge effects on the absorption of copolymers of N(2-hydroxyethyl)-DL-aspartamide with DL-aspartic acid or dimethylaminopropyl-DL-aspartamide. Pharm Res 16:1104-1108.
12. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. editors. 1994. Molecular biology of the cell. 3rd ed.; New York: Garland Publishing, Inc., Chapter 11, pp 508-550.
13. Hostetter MW, Dawson CA, Moore L. 1981. Influence of temperature on the absorption of inhaled bovine serum albumin through isolated rabbit lungs. Proc Soc Exp Biol Med 167:312-418.
14. Hanstein WG. 1976. Uncoupling of oxidative phosphorylation. Biochim Biophys Acta 456:129-148.
15. Steen H, Maring JG, Meijer DKF. 1993. Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in rat liver. Biochem Pharmacol 45:809-818.
16. Iwamoto K, Watanabe J, Yonekawa H. 1989. Effects of metabolic inhibitors and incubation temperature on the saturable uptake of propranolol by isolated rat lung tissue. J Pharm Pharmacol 41:572-574.
17. Basset G, Saumon G, Crone C. 1994. Fluid and electrolyte transport in the isolated lung. In: Effros RM, Chang HK, editors. Fluid and solute transport in the airspaces of the lungs. New York: Marcel Dekker, Inc. pp 71-100.
18. Wangensteen OD, Bartlett MM, James JK, Yang Z, Low PS. 1996. Riboflavin-enhanced transport of serum albumin across the distal pulmonary epithelium. Pharm Res 13:1861-1864.
19. Dinter A, Berger EG. 1998. Golgi-disturbing agents. Histochem Cell Biol 109:571-590.
20. Byron PR, Niven RW. 1988. A novel dosing method for drug administration to the airways of the isolated perfused rat lung. J Pharm Sci 77:693-695.
21. + transport in isolated perfused rat lungs. Am J Respir Cell Mol Biol 9:157-165.
22. Byron PR, Roberts NSR, Clark AR. 1986. An isolated perfused rat lung preparation for the study of aerosolized drug deposition and absorption. J Pharm Sci 75:168-171.
23. Matsukawa Y, Lee VHL, Crandall ED, Kim KJ. 1997. Size-dependent dextran transport across rat alveolar epithelial cell monolayers. J Pharm Sci 86:305-309.
24. Sakagami M, Byron PR, Rypacek F. 1998. Effects of reduced temperature on drug and macromolecule absorption from the airways of the isolated perfused rat lung. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery VI. Buffalo Grove, IL: Interpharm Press, Inc. pp 407-409.
25. Effros RM, Mason GR, Hukkanen J, Silverman P. 1989. New evidence for active sodium transport from fluid-filled rat lungs. J Appl Physiol 66:906-919.
26. Saumon G, Basset G. 1993. Electrolyte and fluid transport across the mature alveolar epithelium. J Appl Physiol 74:1-15.
27. Weibel ER. 1985. Lung cell biology. In: American Physiological Society, editor. Handbook of physiology, Vol. I,; Baltimore, MD: Lippincott, Williams & Wilkins, Chapter 2, pp 47-91.
28. Sakagami M, Byron PR. 2001. Osmotic effects on solute absorption from the airways: Implications for solute-uncoupled alveolar fluid transport. AAPS Pharm Sci3(3)http://www.aapspharmaceutica.com/search/abstract_view.asp?id=575.
29. Martin AN. 1993. Physical pharmacy, 4th ed.; Philadelphia, PA: Lea & Febiger, Chapters 10 and 13, pp 212-250 and 324-361.
30. Camner P, Mossberg B. 1993. Airway mucus clearance and mucociliary transport. In: Moren F, Dolovich MB, Newhouse MT, Newman SP, editors. Aerosols in medicine: Principle, diagnosis and therapy. The Netherlands: Elsevier Science Publishers. pp 247-260.
31. Lanseley AB. 1993. Mucociliary clearance and drug delivery via the respiratory tract. Adv Drug Delivery Rev 11:299-327.
32. Saldias FJ, Comellas A, Guerrero C, Ridge KM, Rutschman DM, Sznajder JI. 1998. Time course of active and passive liquid and solute movement in the isolated perfused rat lung model. J Appl Physiol 85:1572-1577.
33. Williams SK, Matthews MA, Wagner RC. 1979. Metabolic studies of the micropinocytic process in the endothelial cells. Microvasc Res 18:175-184.
34. Wangensteen D. 1990. Microstructural aspects of macromolecule transport across pulmonary epithelium. In: Dalby RN, Evans R, editors. Respiratory drug delivery II. Lexington, KY: University of Kentucky. pp 117-140.
35. Borchardt RT, Smith PL, Wilson G. 1996. Models for assessing drug absorption and metabolism. New York: Plenum Pub Corp.
36. Basset DJP, Fisher AB. 1976. Stimulation of rat lung metabolism with 2,4-dinitrophenol and phenazine methosulfate. Am J Physiol 231:898-902.
37. + transport by cultured monolayers of pulmonary alveolar epithelial cells. Am J Physiol 245:C78-C83.
38. Rose AM, Valdes R. 1994. Understanding the sodium pump and its relevance to disease. Clin Chem 40:1674-1685.
39. Miller RW. 1973. Allosteric inhibitors. In: Mochster RM, Kates M, Quastel JH, editors. Metabolic inhibitors, Vol. IV. New York: Academic Press. pp 1-44.
40. Stenseth K, Thyberg J. 1989. Monensin and chloroquine inhibit transfer to lysosomes of endocytosed macromolecules in cultured mouse peritoneal macrophages. Eur J Cell Biol 49:326-333.
41. Deffebach MF, Bryan CJ, Hoy CM. 1996. Protein movement across cultured guinea pig trachea: Specificity and effect of transcytosis inhibitors. Am J Physiol 271:L744-L752.
42. Wileman T, Boshans RL, Schlesinger P, Stahl P. 1984. Monensin inhibits recycling of macrophage mannose-glycoprotein receptors and ligand delivery to lysosomes. Biochem J 220:665-675.
43. Turner JR, Tartakoff AM. 1989. The response of the Golgi complex to microtubule alteration: The roles of metabolic energy and membrane traffic in Golgi complex organization. J Cell Biol 109:2081-2088.
44. Breitfeld PP, McKinnon WC, Mostor KE. 1990. Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells. J Cell Biol 111:2365-2373.
45. Matter K, Bucher K, Hauri HP. 1990. Microtubule perturbation retards both the direct and the indirect apical pathway but not affect sorting of plasma membrane proteins in intestinal epithelial cells (Caco-2). EMBO J 9:3163-3170.
46. Rypacek F, Drobnik J, Chmelar V, Kalal J. 1982. The renal excretion and retention of macromolecules: The chemical structure effect. Pflugers Arch 392:211-217.
47. Duncan R, Starling D, Rypacek F, Drobnik J, Lloyd JB. 1982. Pinocytosis of poly-α,β[N(2-hydroxyethyl)-D,L-aspartamide] and a tyramine derivative by rat visceral yolk sacs cultured in vitro. Biochim Biophys Acta 717:248-254.
48. Rypacek F, Sramek B, Drobnik J, Kvetina J. 1985. Retention and biliary excretion of poly-α,β[N(2hydroxyethyl)-D,L-aspartamide] (PHEA) and its tyramine derivative (PHEA-Tyr) by isolated perfused rat liver: The role of molecular weight and chemical structure. Biomaterials 6:203-207.