Drug absorption from the isolated perfused rat lung - Correlations with drug physicochemical properties and epithelial permeability

Journal of Drug Targeting

Volumn 11, Issue 1, 2003, Pages 61-74

  Tronde, Anne ^a,b   Nordén, Bo ^b   Jeppsson, Ann Britt ^b   Brunmark, Per ^b   Nilsson, Elisabeth ^b,c   Lennernäs, Hans ^a   Bengtsson, Ursula Hultkvist ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Drug transport; In vitro in vivo correlation; Isolated perfused lung; Permeability; Physicochemical properties; Pulmonary delivery

Indexed keywords

ATENOLOL; BUDESONIDE; DEXTRAN; ENALAPRIL; ENALAPRILAT; FORMOTEROL; LOSARTAN; METOPROLOL; PROPRANOLOL; TERBUTALINE; TETRAPEPTIDE;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG ABSORPTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG STRUCTURE; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; ISOLATED LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG PERFUSION; LUNG VENTILATION; MALE; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; MULTIVARIATE ANALYSIS; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

ABSORPTION; ANIMALS; CACO-2 CELLS; CHEMISTRY, PHYSICAL; EPITHELIUM; HUMANS; LUNG; MALE; PERFUSION; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0038408540     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1061186031000086117     Document Type: Article

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