Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

Nature Medicine

Volumn 11, Issue 4, 2005, Pages 434-439

  Saito, Takashi ^a   Iwata, Nobuhisa ^a   Tsubuki, Satoshi ^a   Takaki, Yoshie ^a   Takano, Jiro ^a   Huang, Shu Ming ^a   Suemoto, Takahiro ^a   Higuchi, Makoto ^a   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; NEUROPEPTIDE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CELL; CATALYSIS; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME LOCALIZATION; FAMILIAL DISEASE; GENE EXPRESSION; GENE MUTATION; HIPPOCAMPUS; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELLS, CULTURED; HIPPOCAMPUS; HUMANS; MICE; MICE, KNOCKOUT; NEPRILYSIN; SOMATOSTATIN; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 17644425569     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1206     Document Type: Article

References (29)

1. Hayashi, M., Yamashita, A. & Shimizu, K. Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNA during aging. Brain Res. 749, 283-289 (1997).
2. Lu, T. et al. Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891 (2004).
3. Davies, P., Katzman, R. & Terry, R.D. Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer's disease and Alzheimer senile dementia. Nature 288, 279-280 (1980).
4. van de Nes, J.A.P., Sandmann-Keil, D. & Braak, H. Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer's disease-related cytoskeletal changes. Acta Neuropathol. 104, 351-356 (2002).
5. Hardy, J. & Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
6. 1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nat. Med. 6, 143-151 (2000).
7. Iwata, N. et al. Metabolic regulation of brain Aβ by neprilysin. Science 292, 1550-1552 (2001).
8. Iwata, N., Takaki, Y., Fukami, S., Tsubuki, S. & Saido, T.C. Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J. Neurosci. Res. 70, 493-500 (2002).
9. Yasojima, K., Akiyama, H., McGeer, E.G. & McGeer, P.L. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide. Neurosci. Lett. 297, 97-100 (2001).
10. Leissring, M.A. et al. Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087-1093 (2003).
11. Iwata, N. et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-β peptide in mouse brain. J. Neurosci. 24, 991-998 (2004).
12. Wang, T.-L., Chang, H., Hung, C.-R. & Tseng, Y.-Z. Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. Cardiovasc. Res. 40, 557-563 (1998).
13. Joshi, D.D. et al. Negative feedback on the effect of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study. Blood 98, 2697-2706 (2001).
14. Hama, E., Shirotani, K., Iwata, N. & Saido, T.C. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons. J. Biol. Chem. 279, 30259-30269 (2004).
15. Shirotani, K. et al. Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J. Biol. Chem. 276, 21895-21901 (2001).
16. Zeyda, T., Diehl, N., Paylor, R., Brennan, M.B. & Hochgeschwender, U. Impairment in motor learning of somatostatin null mutant mice. Brain Res. 906, 107-114 (2001).
17. Shimon, I. et al. Somatostatin receptor subtype specificity in human fetal pituitary cultures. J. Clin. Invest. 99, 789-798 (1997).
18. Garcia-Jimenez, A., Fastbom, J., Winbland, B. & Cowburn, R.F. G-protein regulation of signal transduction in Alzheimer's disease. Brain Aging 2, 7-15 (2002).
19. Moller, L.N., Stidsen, C.E., Hartmann, B. & Holst, J.J. Somatostatin receptors. Biochim. Biophys. Acta 1616, 1-84 (2003).
20. Miesenbock, G., De Angelis, D. A. & Rothman, J.E. Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 334, 192-195 (1998).
21. Bruno, J.F., Xu, Y., Song, J. & Berelowitz, M. Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc. Natl. Acad. Sci. USA 89, 11151-11155 (1992).
22. Doggrell, S.A. The potential of activation of somatostatinergic neurotransmission with FK960 in Alzheimer's disease. Expert Opin. Investig. Drugs 13, 69-72 (2004).
23. Citron, M. β-Secretase: progress and open questions. in Aβ Metabolism and Alzheimer's Disease, (ed. Saido, T.C.) 17-25 (Landes Bioscience, Georgetown, 2003).
24. Wolfe, M.S. γ-Secretase and presenilin. in Aβ Metabolism and Alzheimer's Disease. (ed. Saido, T.C.) 33-47 (Landes Bioscience, Georgetown, 2003).
25. Hama, E. et al. Clearance of extracellular and cell-associated amyloid β peptide by viral expression of neprilysin in primary culture. J. Biochem. 130, 721-726 (2001).
26. Back, S.A. & Gorestein, C. Histochemical visualization of neutral endopeptidase-24.11 (enkephalinase) activity in rat brain: cellular localization and codistribution with enkephalins in the globus pallidus. J. Neurosci. 9, 4439-4455 (1989).
27. Takano, J., Watanabe, M., Hitomi, K. & Maki, M. Four types of calpastatin isoforms with distinct amino-terminal sequences are specified by alternative first exons and differentially expressed in mouse tissues. J. Biochem. 128, 83-92 (2000).
28. Jinno, S. & Kosaka, T. Patterns of expression of neuropeptides in GABAergic nonprincipal neurons in the mouse hippocampus: Quantitative analysis with optical disector. J. Comp. Neurol. 461, 333-349 (2003).
29. Wang, G. et al. Tyramide signal amplification method in multiple-label immunofluorescence confocal microscopy. Methods 18, 459-464 (1999).