Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

Nature Immunology

Volumn 4, Issue 5, 2003, Pages 471-477

  Karaghiosoff, Marina ^a   Steinborn, Ralf ^a,b   Kovarik, Pavel ^c   Kriegshäuser, Gernot ^d   Baccarin, Manuela ^c   Donabauer, Birgit ^a   Reichart, Ursula ^b   Kolbe, Thomas ^e   Bogdan, Christian ^f   Leanderson, Tomas ^g   Levy, David ^h   Decker, Thomas ^c   Müller, Mathias ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c Vienna Biocenter   (Austria)

^d VIENNALAB DIAGNOSTICS GMBH   (Austria)

^e IFA Tulln ^*  (Austria)

^f UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^g LUND UNIVERSITY   (Sweden)

^h NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIUM LIPOPOLYSACCHARIDE; BETA INTERFERON; INTERFERON; MESSENGER RNA; NITRIC OXIDE; PROTEIN TYK2; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; IMMUNOMODULATION; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; WESTERN BLOTTING;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; INTERFERON-ALPHA; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; PROTEINS; RNA, MESSENGER; SHOCK, SEPTIC; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYK2 KINASE;

EID: 0038476601     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni910     Document Type: Article

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