Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase

Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2001, Pages 78-93

  Selwood, D L ^a   Brummell, D G ^b   Budworth, J ^b   Burtin, G E ^a   Campbell, R O ^b   Chana, S S ^a   Charles, I G ^b   Fernandez, P A ^a   Glen, R C ^a   Goggin, M C ^a   Hobbs, A J ^b   Kling, M R ^a   Liu, Q ^a   Madge, D J ^a   Meillerais, S ^b   Powell, K L ^b   Reynolds, K ^a   Spacey, G D ^b   Stables, J N ^b   Tatlock, M A ^b   Wheeler, K A ^b   Wishart, G ^a   Woo, C K ^a   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TRIPOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 (3 DIMETHYLAMINOPROPYLOXY) 5 (4 METHOXYPHENYLAMINOCARBONYL) 1H PYRAZOLE; 1 BENZYL 3 (3 DIMETHYLAMINOPROPYLOXY) 5 PHENYL 1H PYRAZOLE; 1 BENZYL 3 HYDROXYINDAZOLE; 1,5 DIPHENYL 3 (3 DIMETHYLAMINOPROPYLOXY) 1H PYRAZOLE; 3 (3 DIMETHYLAMINOPROPYLOXY) 5 BENZYL 1H PYRAZOLE; BENZYDAMINE; DRUG RECEPTOR; GUANYLATE CYCLASE; INDAZOLE DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIPOPHILICITY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

ANIMALS; ENZYME ACTIVATION; GUANYLATE CYCLASE; HUMANS; INDAZOLES; MALE; NITRIC OXIDE; PLATELET AGGREGATION INHIBITORS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035804329     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001034k     Document Type: Article

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