Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase

European Journal of Pharmacology

Volumn 513, Issue 1-2, 2005, Pages 67-74

  Schmidt, Peter M ^a,b   Rothkegel, Christiane ^a   Wunder, Frank ^a   Schröder, Henning ^c   Stasch, Johannes Peter ^a  

^a Cardiovascular Research   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

BAY 41 2272; BAY 58 2667; cGMP; Heme; Nitric oxide; Soluble guanylate cyclase; YC 1

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (N,N DIETHYLAMINO)DIAZENOLATE 2 OXIDE; 4 [4 CARBOXYBUTYL [2 [(4 PHENETHYLBENZYL)OXY]PHENETHYL]AMINO] METHYL(BENZOIC)ACID; 4 [[4 CARBOXYBUTYL[2 [(4 PHENETHYLBENZYL)OXY]PHENETHYL]AMINO]METHYL]BENZOIC ACID; 4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; HEME; NITRIC OXIDE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOSENSOR; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME STABILITY; FEMALE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BENZOIC ACIDS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC GMP; DIETHYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GENOTYPE; GUANYLATE CYCLASE; HEME; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NITRIC ACID; NITROGEN OXIDES; OXADIAZOLES; PROTOPORPHYRINS; PYRAZOLES; PYRIDINES; QUINOXALINES; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SOLUBILITY; TRANSFECTION;

EID: 18844379136     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.02.046     Document Type: Article

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