Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: Role of soluble guanylyl cyclase

Hypertension

Volumn 35, Issue 1 II, 2000, Pages 231-236

  Brandes, Ralf P ^a   Kim, Do Yei ^b   Schmitz Winnenthal, Friedrich Hubertus ^b   Amidi, Mojgan ^b   Gödecke, Axel ^b   Mülsch, Alexander ^b   Busse, Rudi ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b NONE

Author keywords

Genes; Mice; Nitric oxide; Vasodilator agents

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; CROMAKALIM; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PROTEIN KINASE C ACTIVATOR; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; ENZYME ACTIVITY; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE; VASODILATATION; WESTERN BLOTTING;

EID: 0033958234     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.35.1.231     Document Type: Conference Paper

References (28)

1. Waldman SA, Murad F. Cyclic GMP synthesis and function. Pharmacol Rev. 1987;39:163-196.
2. Dinerman JL, Lawson DL, Mehta JL. Modulation of the vasodilator action of SIN-1 by the endothelium. J Cardiovasc Pharmacol. 1991;260: H698-H701.
3. Moncada S, Rees DD, Schultz R, Palmer RMJ. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA. 1991;88:2166-2166.
4. Pohl U, Busse R. Endothelium-derived relaxant factor inhibits effects of nitrocompounds in isolated arteries. Am J Physiol. 1987;252:H307-H313.
5. Shirasaki Y, Su C. Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite. Eur J Pharmacol. 1985; 114:93-96.
6. Gödecke A, Decking UKM, Ding Z, Hirchenhain J, Bidmon H, Gödecke S, Schrader J. Coronary hemodynamics in endothelial NO synthase knockout mice. Circ Res. 1998;82:186-194.
7. Brandes RP, Koddenberg G, Gwinner W, Kim D, Kruse HJ, Busse R, Mügge A. Role of increase production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia. Hypertension. 1999;33:1243-1249.
8. Jackson WF, Mülsch A, Busse R. Rhythmic smooth muscle activity in hamster aortas is mediated by continuous release of nitric oxide from the endothelium. Am J Physiol. 1991;260:H248-H253.
9. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;277:680-685.
10. Mülsch A, Busse R, Liebau S, Förstermann U. LY interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J Pharmacol Exp Ther. 1988;247:283-288.
11. Yuen PST, Doolittle KL, Garbers DL. Dominant negative mutants of nitric oxide-sensitive guanylyl cyclase. J Biol Chem. 1994;269:791-793.
12. Papapetropoulos A, Abou-Mohamed G, Marczin N, Murad F, Caldwell W, Catravas JD. Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β. Br J Pharmacol. 1996;118:1359-1366.
13. Peters TS, Lewis SJ. Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo. J Pharmacol Exp Ther. 1996;279:918-925.
14. Ohashi Y, Kawashima S, Hirata K, Yamashita T, Ishida T, Inoue N, Sakoda T, Kurihara H, Yazaki Y, Yokoyama M. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest. 1998;102: 2061-2071.
15. Kojda G, Laursen JB, Ramasamy S, Kent JD, Kurz S, Burchfield J, Shesely EG, Harrision DG. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contribution of NOS isoforms to blood pressure and heart rate control. Cardiovasc Res. 1999;42:206-213.
16. Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol. 1998;274:H564-H570.
17. Filippov G, Bloch DB, Bloch KD. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest. 1997;100:942-948.
18. Brandes RP, Gräper S, Busse R, Mügge A, Mülsch A. Lipopolysaccharide treatment induces nitrate tolerance and down-regulates the soluble guanylyl cyclase in the rat aorta. Circulation. 1998;98(suppl I):I-112. Abstract.
19. Scott WS, Nakayama DK. Sustained nitric oxide exposure decreases soluble guanylate cyclase mRNA and enzyme activity in pulmonary artery smooth muscle. J Surg Res. 1998;79:66-70.
20. Bauersachs J, Bouloumie A, Fraccarollo D, Hu K, Busse R, Ertl G. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression. Circulation. 1999;100:292-298.
21. Itoh H, Bird IM, Nakao K, Magness RR. Pregnancy increases soluble and particulate guanylate cyclases and decreases the clearance receptor of natriuretic peptides in ovine uterine, but not systemic arteries. Endocrinology. 1998;138:3329-3341.
22. Tsuchida S, Hiraoka M, Sudo M, Kigoshi S, Muramatsu I. Attenuation of sodium nitroprusside responses after prolonged incubation of rat aorta with endotoxin. Am J Physiol. 1994;267:H2305-H2310.
23. Papapetropoulos A, Go CY, Murad F, Catravas JD. Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells. Br J Pharmacol. 1996;117:147-155.
24. Jackson WF, Busse R. Elevated guanosine 3′:5′-cyclic monophosphate mediates the depression of nitrovasodilator reactivity in endothelium-intact blood vessels. Naunyn-Schmiedeberg's Arch Pharmacol. 1991;344: 345-350.
25. Butt E, Nolte C, Schulz S, Beltman J, Beavo JA, Jastorff B, Water U. Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-parachlorophenylthio-cGMP. Biochem Pharmacol. 1992;43:2591-2600.
26. Schrammel A, Behrends S, Schmidt K, Doesling D, Mayer B. Characterization of 1H-[1,2,4]oxadizolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol. 1996;50:1-5.
27. Diesen SP, Drejer J, Axelsson O, Moldt P, Bang L, Busse R, Mülsch A. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol. 1998;123:299-309.
28. Iesaki T, Gupte SA, Wolin MS. A flavoprotein mechanism appears to prevent an oxygen-dependent inhibition of cGMP-associated nitric oxide-elicited relaxation of bovine coronary arteries. Circulation. 1998; 98(suppl I):I-666. Abstract.