BAY 41-2272: A stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo

Urology

Volumn 61, Issue 2, 2003, Pages 464-467

  Bischoff, E ^a   Schramm, M ^a   Straub, A ^a   Feurer, A ^a   Stasch, J P ^a  

^a BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; CYCLIC GMP; GUANYLATE CYCLASE ACTIVATOR; NITRIC OXIDE; NITROPRUSSIDE SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT;

EID: 0037320842     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(02)02121-0     Document Type: Article

References (14)

1. Anderson K.-E., Wagner G. Physiology of penile erection. Physiol Rev. 75:1995;191-236.
2. Meinhardt W., Kropmann R.F., Vermeig P., et al. The influence of medication on erectile dysfunction. Int J Impot Res. 9:1997;17-26.
3. Ignarro L.J., Bush P.A., Buga G.M., et al. Nitric oxide and cyclic GMP formation upon electric field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. 170:1990;843-850.
4. Lugg J.A., Gonzales-Cadaved N.F., Rajfer J. The role of nitric oxide in erectile function. J Androl. 16:1995;2-4.
5. Lue T.F. Erectile dysfunction. N Engl J Med. 342:2000;1802-1813.
6. Moncada S. Mechanism of disease the L-argininenitric-oxide pathway . N Engl J Med. 329:1993;2002-2012.
7. Boolell M., Allen M.J., Ballard S.A., et al. Sildenafil - an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 8:1996;47-52.
8. Brioni J.D., Nakane M., Hsieh G.C., et al. Activators of soluble guanylyl cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 14:2002;8-14.
9. Mizusawa H, Hedlund P, Brioni JD, et al: Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat. J Urol 167: 2276-2281, 2002.
10. Stasch J.-P., Becker E.M., Alonso Alija C., et al. NO-independent regulatory site on soluble guanylate cyclase. Nature. 401:2001;212-215.
11. Straub A., Alonso Alija C., Benet Buchholz J., et al. NO-independent stimulators of soluble guanylate cyclase. Bioorg Med Chem Lett. 11:2001;781-784.
12. Bischoff E., Schneider K. A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. Int J Impot Res. 13:2001;230-235.
13. Bischoff E., Niewoehner U., Haning H., et al. The oral efficacy of vardenafil hydrochloride for inducing penile erection in a conscious rabbit model. J Urol. 165:2001;1316-1318.
14. Naganuma H., Egashira T., Fujii J. Neuroleptics induce penile erection in the rabbit. Clin Exper Pharmacol Physiol. 20:1993;177-183.