In silico metabolism studies in drug discovery: Prediction of metabolic stability

Current Computer-Aided Drug Design

Volumn 2, Issue 2, 2006, Pages 177-188

  Gombar, Vijay K ^a   Alberts, James J ^a   Cassidy, Kenneth C ^a   Mattioni, Brian E ^a   Mohutsky, Michael A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

ADME; ADME software; Drug discovery; In silico; Metabolic stability; Metabolism; QSAR models

Indexed keywords

COMPUTATIONAL CHEMISTRY; PHYSIOLOGY; SCAFFOLDS; STABILITY;

ABSORPTION DISTRIBUTION METABOLISM AND EXCRETIONS; ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION SOFTWARE; DRUG DEVELOPMENT; DRUG DISCOVERY; IN-SILICO; IN-SILICO MODELS; METABOLIC STABILITY; PROPERTY; QSAR MODEL;

METABOLISM;

ACETIC ACID DERIVATIVE; DULOXETINE; GLUCURONIDE; SULFATE;

CLINICAL STUDY; COMPUTER MODEL; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG INDUSTRY; DRUG METABOLISM; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FINANCIAL MANAGEMENT; PREDICTION; REVIEW;

EID: 33746172633     PISSN: 15734099     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340906777441726     Document Type: Review

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