Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4072-4081

  Ridderstrom M ^a   Zamora, I ^a   Fjellstrom O ^a   Andersson, T B ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; DICLOFENAC; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ANALYSIS; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; MODEL; MOLECULAR INTERACTION; NONHUMAN; RABBIT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035935677     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109107     Document Type: Article

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