Development and validation of κ-nearest-neighbor QSPR models of metabolic stability of drug candidates

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3013-3020

  Shen, Min ^a   Xiao, Yunde ^a   Golbraikh, Alexander ^a   Gombar, Vijay K ^b   Tropsha, Alexander ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOAVAILABILITY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STABILITY; HUMAN; HUMAN CELL; LIVER HOMOGENATE; METABOLIC REGULATION; MODEL; QUANTITATIVE STRUCTURE PROPERTY RELATION; VALIDATION PROCESS; ALGORITHM; CHEMICAL STRUCTURE; CHEMISTRY; IN VITRO STUDY; LIVER; METABOLISM; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

DRUG;

ALGORITHMS; DRUG STABILITY; HUMANS; LIVER; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038121705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020491t     Document Type: Article

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