Molecular modeling of cytochrome P450 1A1: Enzyme-substrate interactions and substrate binding affinities

Journal of Biomolecular Structure and Dynamics

Volumn 20, Issue 2, 2002, Pages 155-162

  Szklarz, Grazyna D ^a   Paulsen, Mark D ^b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b NORTHERN MICHIGAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7-METHOXYRESORUFIN; BENZO[A]PYRENE; CYTOCHROME P450 1A1; ETHOXYRESORUFIN; LIGAND; METHOXYRESORUFIN; OXAZINE DERIVATIVE; WATER; CARCINOGEN; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; ENZYME SPECIFICITY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY; BINDING AFFINITY; CHEMICAL CARCINOGENESIS; ENERGY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; MOLECULAR MODEL; OXIDATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TOXICOKINETICS;

AMINO ACID SEQUENCE; BENZO(A)PYRENE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP1A1; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXAZINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; WATER;

EID: 0036805854     PISSN: 07391102     EISSN: None     Source Type: Journal    
DOI: 10.1080/07391102.2002.10506831     Document Type: Article

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