Molecular modeling of cytochrome P450 3A4

Journal of Computer-Aided Molecular Design

Volumn 11, Issue 3, 1997, Pages 265-272

  Szklarz, Grazyna D ^a   Halpert, James R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cytochrome P450 3A4; Human drug metabolism; Molecular modeling; Structure function relationships; Substrate docking

Indexed keywords

ANTIBIOTICS; ENZYMES; HYDROPHOBICITY;

ACTIVE SITE; CYTOCHROME P450-3A4; DRUG METABOLISMS; HUMAN CYTOCHROMES P450; HUMAN DRUG METABOLISM; KEY RESIDUES; PROGESTERON; STRUCTURE-FUNCTION RELATIONSHIP; SUBSTRATE DOCKING; THREE-DIMENSIONAL STRUCTURE;

MOLECULAR MODELING;

CYP3A PROTEIN, HUMAN; CYTOCHROME P450; ERYTHROMYCIN; MIXED FUNCTION OXIDASE; PROGESTERONE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; HUMAN; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; HUMANS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROGESTERONE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE ALIGNMENT;

EID: 0031133347     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007956612081     Document Type: Article

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